A5058969992- Endoplasmic Reticulum Stress and Disease
- Inflammatory mediators and NSAID effects
- Autophagy in Disease and Therapy
- Curcumin's Biomedical Applications
- Polyamine Metabolism and Applications
- Eicosanoids and Hypertension Pharmacology
- Sirtuins and Resveratrol in Medicine
- Cholesterol and Lipid Metabolism
- Biological and pharmacological studies of plants
- Bioactive natural compounds
- Sulfur-Based Synthesis Techniques
- Cannabis and Cannabinoid Research
- Macrophage Migration Inhibitory Factor
- Cancer, Lipids, and Metabolism
- Click Chemistry and Applications
- Natural product bioactivities and synthesis
- Lipid metabolism and biosynthesis
- Peroxisome Proliferator-Activated Receptors
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Sphingolipid Metabolism and Signaling
- Fatty Acid Research and Health
Universität Innsbruck
2022-2025
Abstract Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including the unfolded protein response (UPR) and autophagy, induces programmed cell death. Fatty acid unsaturation, controlled by stearoyl-CoA desaturase (SCD)1, prevents cytotoxic but mechanisms are diffuse. Here, we show that 1,2-dioleoyl- sn -glycero-3-phospho-(1’-myo-inositol) [PI(18:1/18:1)] is a SCD1-derived signaling lipid, which inhibits p38 mitogen-activated kinase activation, counteracts...
Abstract Cell death programs such as apoptosis and ferroptosis are associated with aberrant redox homeostasis linked to lipid metabolism membrane function. Evidence for cross-talk between these is emerging. Here, we show that cytotoxic stress channels polyunsaturated fatty acids via lysophospholipid acyltransferase 12 into phospholipids become susceptible peroxidation under additional stress. This reprogramming altered acyl-CoA synthetase isoenzyme expression caused by a decrease in growth...
Polypharmacological targeting of lipid mediator networks offers potential for efficient and safe anti-inflammatory therapy. Because the diversity its biological targets, curcumin (1a) has been viewed as a privileged structure bioactivity or, alternatively, pan-assay interference (PAIN) compound. Curcumin actually few high-affinity most remarkable ones being 5-lipoxygenase (5-LOX) microsomal prostaglandin E2 synthase (mPGES)-1. These enzymes are critical production pro-inflammatory...
The growing general interest surrounding Cannabis sativa L. has led to a renewal in breeding and resulted an impressive variability of chemotypical characteristics that required the division cannabis into different recognized chemotypes. chemotype V been overlooked terms phytochemical composition due almost total absence cannabinoids, on which biomedical attention is focused. Systematic approaches addressing diverse chemotypes are, however, needed discriminate define aspects beyond...
Abstract Lipidomics-guided screening of unexplored chemical space in natural products provides access to small molecules capable modifying cellular lipid profiles on a global scale. Here, we show that the meroterpenoid cyclosmenospongine from Spongia sp . shapes profile immune cells, favoring anti-inflammatory and pro-resolving over pro-inflammatory mediators. Structural variation revealed derivatives inhibit leukotriene biosynthesis varying extents while differentially upregulating...
Inflammatory responses are orchestrated by a plethora of lipid mediators, and perturbations their biosynthesis or degradation hinder resolution lead to uncontrolled inflammation, which contributes diverse pathologies. Small molecules that induce switch from pro-inflammatory anti-inflammatory mediators considered valuable for the treatment chronic inflammatory diseases. Commonly used non-steroidal drugs (NSAIDs) afflicted with side effects caused inhibition beneficial prostanoid formation...
Abstract Tumours face tryptophan (Trp) depletion, but the mechanisms sustaining protein biosynthesis under Trp stress remain unclear. We report that increases levels of translation repressor EIF4EBP1. Yet, at same time, EIF4EBP1 is selectively phosphorylated by metabolic master regulator MTORC1 kinase, preventing from inhibiting translation. activity unexpected because absence amino acids typically linked with inhibition. EIF4EBP1-sensitive in starved cells sustained EGFR and RAS signalling...
Inflammatory responses are orchestrated by a plethora of lipid mediators, and perturbations their biosynthesis or degradation hinder resolution lead to uncontrolled inflammation, which contributes diverse pathologies. Small molecules that induce switch from pro-inflammatory anti-inflammatory mediators considered valuable for the treatment chronic inflammatory diseases. Commonly used non-steroidal drugs (NSAIDs) afflicted with side effects caused inhibition beneficial prostanoid formation...