A5076233616- Mass Spectrometry Techniques and Applications
- Autophagy in Disease and Therapy
- Ion-surface interactions and analysis
- Polyamine Metabolism and Applications
- Endoplasmic Reticulum Stress and Disease
- Nuclear Physics and Applications
- Advanced Proteomics Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
Mannheim University of Applied Sciences
2023-2025
Heidelberg University
2023
University Hospital Heidelberg
2023
Bernstein Center for Computational Neuroscience Heidelberg-Mannheim
2023
University of Sulaimani
2023
Abstract Mass spectrometry imaging vows to enable simultaneous spatially resolved investigation of hundreds metabolites in tissues, but it primarily relies on traditional ion images for non-data-driven metabolite visualization and analysis. The rendering interpretation neither considers nonlinearities the resolving power mass spectrometers nor does yet evaluate statistical significance differential spatial abundance. Here, we outline computational framework moleculaR (...
The deposition of matrix compounds significantly influences the effectiveness matrix-assisted laser desorption/ionization (MALDI) Mass Spectrometry Imaging (MSI) experiments, impacting sensitivity, spatial resolution, and reproducibility. Dry methods offer advantages by producing homogeneous layers minimizing analyte delocalization without use solvents. However, refining these techniques to precisely control thickness, minimize heating temperatures, ensure high-purity is crucial for...
The deposition of matrix compounds significantly influences the effectiveness matrix-assisted laser desorption/ionization (MALDI) Mass Spectrometry Imaging (MSI) experiments, impacting sensitivity, spatial resolution, and reproducibility. Dry methods offer advantages by producing homogeneous layers minimizing analyte delocalization without use solvents. However, refining these techniques to precisely control thickness, minimize heating temperatures, ensure high-purity is crucial for...
Background: Toxoplasma gondii is an opportunistic protozoan parasite that causes a life-threatening disease – toxoplasmosis in immunocompromised individuals, including patients with cancer. This prospective cross-sectional study set out to determine the prevalence of cancer compared healthy individuals. Methods: A was conducted Sulaimani City Iraq from November 2019 May 2020. Anti-T. IgG and IgM antibodies were measured blood samples 113 (80 solid organ tumors 33 haematological malignancies)...
Abstract Tumours face tryptophan (Trp) depletion, but the mechanisms sustaining protein biosynthesis under Trp stress remain unclear. We report that increases levels of translation repressor EIF4EBP1. Yet, at same time, EIF4EBP1 is selectively phosphorylated by metabolic master regulator MTORC1 kinase, preventing from inhibiting translation. activity unexpected because absence amino acids typically linked with inhibition. EIF4EBP1-sensitive in starved cells sustained EGFR and RAS signalling...