A5061477126- Tryptophan and brain disorders
- E-Learning and Knowledge Management
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Adenosine and Purinergic Signaling
- Family Support in Illness
- Educational theories and practices
- Autophagy in Disease and Therapy
- Science, Technology, and Education in Latin America
- Stress Responses and Cortisol
- Cancer, Hypoxia, and Metabolism
- Polyamine Metabolism and Applications
- Educational Research and Science Teaching
- Bipolar Disorder and Treatment
- Endoplasmic Reticulum Stress and Disease
- Epigenetics and DNA Methylation
Heidelberg University
2017-2023
German Cancer Research Center
2017-2023
Universidad de Costa Rica
1970-2021
Memorial Sloan Kettering Cancer Center
2021
Brain (Germany)
2019
Aryl hydrocarbon receptor (AHR) activation by tryptophan (Trp) catabolites enhances tumor malignancy and suppresses anti-tumor immunity. The context specificity of AHR target genes has so far impeded systematic investigation activity its upstream enzymes across human cancers. A pan-tissue signature, derived natural language processing, revealed that 32 entities, interleukin-4-induced-1 (IL4I1) associates more frequently with than IDO1 or TDO2, hitherto recognized as the main Trp-catabolic...
Kynurenine formation by tryptophan-catabolic indoleamine-2,3-dioxygenase 1 (IDO1) plays a key role in tumor immune evasion and inhibition of IDO1 is efficacious preclinical models breast cancer. As the response cancer to checkpoint inhibitors may be limited, better understanding expression additional targetable immunomodulatory pathways importance. We therefore investigated regulation different subtypes. identified estrogen receptor α (ER) as negative regulator expression. Serum kynurenine...
El curso MQ-203 Bioquímica para Microbiología, fue impartido del 2006 al 2010 mediante clases magistrales en donde la evaluación aprendizaje de los estudiantes se llevó a cabo exclusivamente exámenes selección única. En el primer semestre 2011, además las magistrales, este cuso implementaron varias actividades cooperativo incluyendo trabajos grupo, estudio y discusión casos clínicos desarrollo un trabajo investigación grupo. Estas tuvieron valor 25% nota final curso. artículo analizan...
Abstract Tumours face tryptophan (Trp) depletion, but the mechanisms sustaining protein biosynthesis under Trp stress remain unclear. We report that increases levels of translation repressor EIF4EBP1. Yet, at same time, EIF4EBP1 is selectively phosphorylated by metabolic master regulator MTORC1 kinase, preventing from inhibiting translation. activity unexpected because absence amino acids typically linked with inhibition. EIF4EBP1-sensitive in starved cells sustained EGFR and RAS signalling...