A5049521775- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Metabolism, Diabetes, and Cancer
- Ocular Surface and Contact Lens
- Asthma and respiratory diseases
- Nanoparticle-Based Drug Delivery
- Liver Disease Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Lipid Membrane Structure and Behavior
- Dermatology and Skin Diseases
- Hedgehog Signaling Pathway Studies
- Nonmelanoma Skin Cancer Studies
- Hepatitis C virus research
- Analytical Methods in Pharmaceuticals
- Diabetes Treatment and Management
- Platelet Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Antibiotic Use and Resistance
- Brucella: diagnosis, epidemiology, treatment
- Cancer and Skin Lesions
- Drug-Induced Hepatotoxicity and Protection
- RNA Interference and Gene Delivery
- Microencapsulation and Drying Processes
Beni-Suef University
2016-2025
October 6 University
2023
Animal Health Research Institute
2021
German Cancer Research Center
2020
Heidelberg University
2020
Aryl hydrocarbon receptor (AHR) activation by tryptophan (Trp) catabolites enhances tumor malignancy and suppresses anti-tumor immunity. The context specificity of AHR target genes has so far impeded systematic investigation activity its upstream enzymes across human cancers. A pan-tissue signature, derived natural language processing, revealed that 32 entities, interleukin-4-induced-1 (IL4I1) associates more frequently with than IDO1 or TDO2, hitherto recognized as the main Trp-catabolic...
The effective treatment of skin carcinoma is warranted for targeting the chemotherapeutic agents into tumor cells and avoiding unwanted systemic absorption.This work was dedicated to purpose engineering highly penetrating shell-enriched nanoparticles that were loaded with a hydrophilic agent, 5-fluorouracil (5-FU).Varying ratios lecithin poloxamer188 used produce by enabling formation reversed micelles within this region SLN. localization 5-FU shell SLN, confirmed using nanogold particles as...
Improvement of water solubility, dissolution rate, oral bioavailability, and reduction first pass metabolism OL (OL), were the aims this research. Co-amorphization carboxylic acid dispersions at various molar ratios was carried out using rapid solvent evaporation. Characterization performed differential scanning calorimetry (DSC), Fourier transform infrared spectrometry (FTIR), X-ray diffractometry (XRD), electron microscopy (SEM). Dispersions with highest equilibrium solubility formulated...
The purpose of the current study was to develop tizanidine HCl (TIZ; a myotonolytic agent used for treatment spasticity) loaded nanotransfersomes intended rectal administration, aiming bypass hepatic first-pass metabolism. TIZ-loaded were prepared by thin-film hydration method followed characterization various parameters including entrapment efficiency, vesicle diameter, in vitro release and ex vivo permeation studies. Transfersomal formulation composed phosphatidylcholine Tween 80 at weight...
The present study describes glycerosomes (vesicles composed of phospholipids, glycerol and water) as a novel drug delivery system for topical application celecoxib (CLX) cupferron (CUP) compound.The goal this research was to design soft innovative vesicles loaded with CLX or CUP enhancing the efficacy avoiding systemic toxicity CUP.CLX were prepared by hydrating phospholipid-cholesterol films aqueous solutions (20-40%, v/v). Box-Behnken design, using Design-Expert® software, optimum choice...
The current study aimed to develop gold nanoparticles (GNPs) and liposome-embedded (LGNPs) as drug carriers for temozolomide (TMZ) investigate the possible therapeutic effects of intratracheal inhalation nanoformulation TMZ-loaded (TGNPs) TGNPs (LTGNPs) against urethane-induced lung cancer in BALB/c mice. Physicochemical characters zeta potential studies were performed. was conducted by inducing chemically via repeated exposure urethane BALB/C GNPs LGNPs exhibited uniform spherical shape...
Resveratrol is a promising neuroprotective agent against neurodegenerative disorders such as Alzheimer's disease. Resveratrol-loaded transferosomes and nanoemulsions were developed labelled with gold nanoparticles (GNPs). The water maze test was utilised to identify the effect on spatial memory recovery. treated rats examined for cellular uptake bioaccumulation of drug in brain using computed tomography (CT) histopathological examination utilising GNPs biomarker. Compared nanoemulsions,...
Although integrin alpha 2 subunit (ITGA2) mediates cancer progression and metastasis, its transfer by exosomes has not been investigated in prostate (PCa). We aimed to determine the role of exosomal ITGA2 derived from castration-resistant PCa (CRPC) cells promoting aggressive phenotypes androgen receptor (AR)-positive cells. Exosomes were co-incubated with recipient tested for different cellular assays. was enriched CRPC Co-culture AR-positive CRPC-derived increased their proliferation,...
Simvastatin (SIM) is a HMG-CoA reductase inhibitor employed in the management of hyperlipidemia. However, its low bioavailability limits clinical efficacy. The objective this study was to overcome poor SIM via transdermal application SIM-loaded niosomal gel. Niosomes loaded with were fabricated by means thin-film hydration method and optimized through 33-factorial design utilizing Design Expert® software. prepared niosomes evaluated for entrapment efficiency (EE%), zeta potential, vesicle...
The goal of the present study was to formulate topical nanocarriers low-cost vasodilator, papaverine hydrochloride (PH), as an alternative painful penile injections. injections are used for both diagnosis and treatment erectile dysfunction. Transdermal nano-transferosome (T), ultraflexible nanoliposome, a nanocarrier enhance penetration penis.Different nano formulas were prepared characterized their encapsulation efficiency, particle size, zeta potential, cumulative drug release. formula...
Bio-identical progesterone (PRG) is an exogenous female steroidal hormone which used for treatment of polycystic ovary syndrome (PCOS). However, it suffers from poor bioavailability due to hepatic metabolism and solubility. The target this work was evaluate statistically optimize PRG-loaded nanovesicle transethosomes (NVTEs) based in mucoadhesive gel transvaginal delivery PRG as potential luteal-phase support. A 24 full factorial design explore the effect phosphatidylcholine (PC), Tween 80,...
Liposomal flucytosine capped with gold nanoparticle formulations for improved ocular delivery Heba F Salem,1 Sayed M Ahmed,2 Mahmoud Omar3 1Department of Pharmaceutics and Industrial Pharmacy, Faculty Beni-Suef University, Beni-Suef, Egypt; 2Department Assiut Assiut, 3Department Deraya El-Minia, Egypt Abstract: Nanoliposomes have an organized architecture that provides versatile functions. In this study, liposomes were used as carrier nanogold antifungal drug. Gold nanoparticles a...
<h3>BACKGROUND:</h3> Pressurized metered-dose inhalers (pMDIs) are among the most commonly used aerosol delivery devices. Poor lung deposition from a pMDI is often result of incorrect inhalation technique. The aim this study was to compare impact combining newly released training device with smartphone application (advanced counseling) in asthma control traditional verbal training. <h3>METHODS:</h3> A total 371 subjects were divided into 2 groups: advanced counseling (<i>n</i> = 187) and...
Throughout the United States and world, skin cancer is most frequent form of cancer. Sonidegib (SNG) a hedgehog inhibitor that has been used for treatment. However, SNG low bioavailability associated with resistance. The focus this work to enhance bioavailability, anti-tumor efficacy targeting via developing ethosome gel as potential treatment SNG-loaded ethosomes formulation was prepared characterized in vitro by %entrapment efficiency (%EE), vesicle size, morphology, %release steady-state...
Duloxetine HCl (DXH) is a reuptake inhibitor of serotonin and norepinephrine used to treat the major depressive disorder. Following its extensive hepatic metabolism, acid-labile nature, limited aqueous solubility, DXH has poor oral bioavailability (40%). The rectal route been suggested as another administration surmount such challenges. present study aimed prepare DXH-loaded glycerosomal (DXH-GLYS) in situ gel for increase permeability improve bioavailability. Box-Behnken design (BBD) was...
Skin cancer is the most frequent throughout world. Vismodegib (VSD) a hedgehog blocker approved for prevention and treatment of skin cancer. VSD, however, poorly bioavailable has been linked to side effects. This work focused on designing nano-invasome gel as vehicle enhancing permeation, bioavailability, efficacy VSD. Additionally, combined effect terpenes ethanol was studied permeation VSD compared with liposomes. The prepared VSD-loaded invasomes (VLI) formulation included cineole...
Cancer is one of the most important causes death worldwide. Several studies have shown efficacy apricot kernel seed as a cancer therapy due to presence amygdalin. These demonstrated amygdalin's cytotoxicity, antioxidant activity, and apoptosis in vitro using human cell lines. However, no their activity vivo. The aim this study develop an amygdalin-loaded niosomes (ALN) gel formulation drug delivery system order investigate selectivity, efficacy, toxicity amygdalin vivo 7,12-dimethylbenz (a)...