A5059951362- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Advanced Glycation End Products research
- Nigella sativa pharmacological applications
- Chemotherapy-induced organ toxicity mitigation
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Pharmacological Effects of Natural Compounds
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related cognitive impairment studies
- Metabolism, Diabetes, and Cancer
- Endoplasmic Reticulum Stress and Disease
- Advanced Drug Delivery Systems
- Genomics, phytochemicals, and oxidative stress
- Alcohol Consumption and Health Effects
- Phytochemical and Pharmacological Studies
- Cytokine Signaling Pathways and Interactions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chromatography in Natural Products
- Chronic Kidney Disease and Diabetes
- Orthopedic Surgery and Rehabilitation
- Elbow and Forearm Trauma Treatment
- Inhalation and Respiratory Drug Delivery
- Biochemical Acid Research Studies
- Plant-based Medicinal Research
Beni-Suef University
2013-2025
National Health Service
2024
Non-alcoholic fatty liver disease (NAFLD) has become one of the most frequent chronic diseases worldwide in recent decades. Metabolic like excessive blood glucose, central obesity, dyslipidemia, hypertension, and function abnormalities cause NAFLD. NAFLD significantly increases likelihood cancer, heart disease, mortality, making it a leading transplants. steatohepatitis (NASH) is more advanced form that causes scarring inflammation over time can ultimately result cirrhosis hepatocellular...
Although integrin alpha 2 subunit (ITGA2) mediates cancer progression and metastasis, its transfer by exosomes has not been investigated in prostate (PCa). We aimed to determine the role of exosomal ITGA2 derived from castration-resistant PCa (CRPC) cells promoting aggressive phenotypes androgen receptor (AR)-positive cells. Exosomes were co-incubated with recipient tested for different cellular assays. was enriched CRPC Co-culture AR-positive CRPC-derived increased their proliferation,...
Abstract Nonalcoholic fatty liver disease (NAFLD) is a common disorder affecting quarter of the global residents. Progression NAFL into nonalcoholic steatohepatitis (NASH) may cause cirrhosis, cancer, and failure. Gut microbiota imbalance causes microbial components translocation circulation, triggering inflammation NASH‐related fibrosis. MicroRNAs (miRNAs) regulate gene expression via repressing target genes. Exosomal miRNAs are diagnostic prognostic biomarkers for NASH damage. Our work...
ABSTRACT Colorectal cancer (CRC) is a multicomponent disease and the second most frequent root of cancer‐related deaths globally. Linagliptin dipeptidyl peptidase‐4 (DPP‐4) inhibitor. It has been repurposed in recent experimental studies due to its marked anti‐inflammatory activities. This study aimed evaluate ameliorative role linagliptin 1,2‐dimethylhydrazine (DMH)‐induced CRC via modulation NFAT‐mediated IL‐6 JAK2/STAT3/NF‐κB signaling pathways. model successfully established dose equal...
Studies have associated advanced glycation end-products (AGEs) and the polymorphism of AGEs receptor (RAGE) gene with clinical disorders, such as diabetes, in certain ethnic groups. However, its association type 1 diabetes mellitus (T1DM) Egyptians has not yet been explored. The aim this study was to investigate between RAGE rs1800625 T1DM susceptibility Egyptians. A case-control conducted 177 patients age- sex-matched healthy controls. Variables included glycemic markers (fasting blood...
BackgroundCisplatin (CP) is a common antineoplastic agent widely used to treat broad spectrum of cancers. However, its usage for cancer treatment was restricted due various side effects such as neurotoxicity, nephrotoxicity, hepatotoxicity and ototoxicity. Neurotoxicity in patients who have undergone complete course chemotherapy clinically evident. CP administration caused problems rats with memory learning.MethodsThe effect combination either thymoquinone (TQ) or geraniol (Ger) on cell...
Apoptosis signal-regulating kinase 1 (ASK1), a redox-sensor mitogen-activated protein (MAPKKK) that activates p38 MAPK pathways in oxidative stress-induced hepatotoxicity D-galactosamine/lipopolysaccharide (D-GalN/LPS) model, is key central pathway which specific targeting of ASK1 deactivation great therapeutic potential. We tested the effect silibinin and vitamin E curative prophylactic manner treatment on negative modulators ASK1, thioredoxin1 (Trx1), thioredoxin reductase1 (TrxR1),...
This study aimed to develop valsartan (VAL)-loaded mixed micelles and investigate their cardioprotective potential molecular mechanisms through Mhrt/Nrf2 Trx1 pathways. VAL-loaded have not been elaborated impact on pathways has yet inspected. were prepared, incorporating Pluronic F127 Tween 80, adopting thin-film hydration method. The evaluated for drug entrapment efficiency, loading characteristics, particle size, morphology, in vitro release storage stability. pharmacokinetic studies...
Pulmonary fibrosis is a serious ailment that may progress to lung remodeling and demolition, where the key participants in its incidence are fibroblasts responding growth factors cellular calcium swinging. Calcium channel blockers, like nifedipine (NFD), represent auspicious agents pulmonary treatment. Unfortunately, NFD bears complicated pharmacodynamics diminished systemic bioavailability. Thus, current study aimed develop novel, non-invasive nanoplatform for direct/effective targeting via...
The interaction of advanced glycation end products (AGEs) and its receptor (RAGE) has played an important role in the pathogenesis diabetes complications. A soluble form RAGE (sRAGE) been reported as a decoy for AGEs. Oxidative stress is demonstrated pathological condition such atherosclerosis mellitus. It suggested to be involved both macro- microvascular This study was designed evaluate effect glycemic control on sRAGE oxidative markers type 2 diabetic patients.Seventy patients with 20...
Type I diabetes mellitus (T1DM) is one of the most common chronic autoimmune diseases worldwide. miRNAs are a class small non-coding RNA molecules that have been linked to immune system functions, β-cell metabolism, proliferation, and death, all which contribute pathogenesis TIDM. Dysregulated identified in Egyptian TIDM patients. Several were profiled patients determine whether they can be used as molecular biomarkers for T1DM. The relationship between investigated pro-inflammatory...
The precise analysis of the contents red carrot is still ambiguous and its role in maintenance male fertility needs to be further reconnoitered. Hence, this study targets physiological impacts either methanolic extract (RCME) or vitamin E (Vit. E), co-administrated with cadmium chloride (CdCl2) on rat testes, specifically those concerned apoptosis oxidative challenge. Four groups adult rats (n = 12) are used; control, CdCl2, CdCl2 + Vit. RCME. LC-MS RCME reveals presence 20 different...
Endoplasmic reticulum (ER) stress was reported to play a major role in non-alcoholic fatty liver disease (NAFLD) induction and progression. Here, we study the effect of Zingiber officinale omega-3 acids on ER for treating NAFLD. Male Wistar rats were fed normal diet (control group) or high-fat (HFD) 8 weeks. The HFD later treated with vehicle, Z. extract. group demonstrated significantly more body weight gain higher plasma lipid profile, glucose, hepatic enzymes. expressions lipogenic ChREBP...
Abstract Diabetes mellitus (DM) is a chronic disorder that affects nearly half billion people around the world and causes millions of deaths annually. Treatment diabetes or related complications represents an economic burden not only for developing countries but also developed ones. Hence, new efficient therapeutic preventive strategies screening tools are necessary. The current work aimed to assess potential association single nucleotide polymorphisms (SNPs) in ghrelin O‐acyltransferase...
Background: Diabetes mellitus (DM) represents one of the most important reasons for chronic kidney diseases due to high level blood glucose that destructs vessels. Objective: The present study focused on investigating protective impact sitagliptin complication in type 2 diabetes (T2DM) patients comparison pioglitazone examine which has superior effect against nephritic DM. Methods: Eighty adult subjects were classified into four groups: control group, pioglitazone-treated T2DM (P group),...
Type I Diabetes, among the ten greatest causes of mortality worldwide, is estimated to afflict 642 million individuals by 2040. It an auto-immune illness brought on association environmental and genetic variables. that cause T lymphocytes destroy insulin-producing β-cells. Its prevalence continues rise 3-4% annually enhancing risk mortality. So, idea diabetic kidney disease (DKD) widely established, systemic treatment essential. RAGEs are linked inflammatory disorders exist in a variety...