A5027665445- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Ocular Surface and Contact Lens
- Dermatology and Skin Diseases
- Lipid Membrane Structure and Behavior
- Drug Transport and Resistance Mechanisms
- Analytical Methods in Pharmaceuticals
- Nanoparticle-Based Drug Delivery
- Corneal Surgery and Treatments
- Wound Healing and Treatments
- Acne and Rosacea Treatments and Effects
- Synthesis and biological activity
- RNA Interference and Gene Delivery
- Antibiotics Pharmacokinetics and Efficacy
- Proteins in Food Systems
- Synthesis of heterocyclic compounds
- Nanocomposite Films for Food Packaging
- Microencapsulation and Drying Processes
- Electrospun Nanofibers in Biomedical Applications
- HER2/EGFR in Cancer Research
- Cancer therapeutics and mechanisms
- Essential Oils and Antimicrobial Activity
- Diabetes Treatment and Management
- Berberine and alkaloids research
Jouf University
2017-2025
Egypt-Japan University of Science and Technology
2024
Alexandria University
2024
Al-Azhar University
2013-2023
University of Helsinki
2013-2014
Cholesterol is an important component of all biological membranes as well drug delivery liposomes. We show here that increasing the level cholesterol in a phospholipid membrane decreases surface charge physiological environment. Through molecular dynamics simulation we have shown Na+ ion binding. Complementary experimental ζ – potential measurements decreased with content, indicative reduced charge. Both experiments and simulations been carried out on both saturated...
Atorvastatin (AT) is a widely used lipid-regulating drug to reduce cholesterol and triglycerides. Its poor aqueous solubility hepatic metabolism require development of delivery systems able improve its bypass effect. For this purpose, atorvastatin nanostructured lipid carriers (AT-NLCs) were prepared characterized. AT-NLCs by emulsification using high-speed homogenization followed ultrasonication. The NLCs showed particle size between 162.5 ± 12 865.55 28 nm while zeta potential values...
Rheumatoid arthritis (RA) is a chronic inflammatory illness affecting the joints. The characteristic of RA gradual joint deterioration. Current treatment alleviates signs such as inflammation and pain substantially slows progression disease. In this study, we aimed to boost transdermal delivery berberine (a natural product) by encapsulating it in chitosan, surface-modified bilosomes nanogel for better management RA. chitosan-coated loaded with (BER-CTS-BLS) were formulated according...
Diabetic (type-2) is a metabolic disease characterized by increased blood glucose level from the normal level. In present study, apigenin (AG) loaded lipid vesicles (bilosomes: BIL) was prepared, optimized and evaluated for oral therapeutic efficacy.AG-BIL prepared thin-film evaporation method using cholesterol, span 60 sodium deoxycholate. The formulation 3-factor 3-level Box-Behnken design particle size, entrapment efficiency drug release as response. selected further ex-vivo permeation,...
Spironolactone (SP), an aldosterone antagonist with anti-androgen properties, has shown promising results in the treatment of female acne. However, its systemic side effects limit clinical benefits. This study aimed to prepare and evaluate LeciPlexes for SP topical delivery. were prepared by a one-step procedure characterized using various techniques. Optimum LeciPlex preparation was incorporated into 1% methylcellulose gel permeability tested ex vivo Sprague-Dawley rat skin. The maximum...
Purpose: The present study was designed to the gentamycin (GTM)-loaded stimulus-responsive chitosan nanoparticles treat bacterial conjunctivitis. Methods: GTM-loaded (GTM-CHNPs) were prepared by ionotropic gelation method and further optimized 3-factor 3-level Box–Behnken design. Chitosan (A), sodium tripolyphosphate (B), stirring speed (C) selected as independent variables. Their effects observed on particle size (PS Y1), entrapment efficiency (EE Y2), loading capacity (LC Y3). Results:...
Conjunctivitis is considered as a common infection of ocular surfaces. Eye drop most commonly used for treatment conjunctivitis, but has some drawback like 95% drug eliminated after administration. Administration levofloxacin to the anterior site in form chitosan coated poly (lactic-co-glycolic acid) nanoparticles (LFV-CS-PLGA-NPs) expected overcome these problem and increasing corneal contact time permeability effective bacterial conjunctivitis. The Nanoparticles were developed by single...
The aim of this work was to prepare and optimize mucoadhesive nanostructured lipid carrier (NLC) impregnated with fluconazole for better management oral candidiasis. NLCs were fabricated using an emulsification/sonication technique. nanoparticles consisted stearic acid, oleic Pluronic F127, lecithin. Box–Behnken design, artificial neural networking, variable weight desirability employed the joint effect drug concentration in drug/lipid mixture, solid solid/liquid surfactant total mixture on...
Diabetes mellitus is a life-threatening metabolic disease. At the moment, there no effective treatment available to combat it. In this study, we aimed develop berberine-loaded bilosomes (BER-BLS) boost oral bioavailability and therapeutic efficacy of berberine, natural antidiabetic medication. The BER-BLS was fabricated using thin-film hydration strategy optimized central composite design (face-centered). average vesicle size, entrapment efficiency, surface charge preparation were 196.5 nm,...
Catechin is a naturally occurring flavonoid of the flavan-3-ol subclass with numerous biological functions; however, these benefits are diminished due to several factors, including low water solubility and degradation in stomach's harsh environment. So, this study aimed develop an intelligent catechin colon-targeting delivery system high loading capacity. This was done by coating surface-decorated mesoporous silica nanoparticles pH-responsive enteric polymer called Eudragit®-S100. The...
Numerous neurological disorders have a pathophysiology that involves an increase in free radical production the brain. Quercetin (QER) is nutraceutical compound shields brain against oxidative stress-induced neurodegeneration. Nonetheless, its low oral bioavailability diminishes delivery. Therefore, current study aimed to formulate QER-loaded transferosomal nanovesicles (QER-TFS) situ gel for QER delivery via intranasal route. This explored impacts of lipid amount, edge activator (EA) and EA...
A rapid, sensitive, and reliable quality by design (QbD) based bioanalytical HPLC method was developed validated for quantification of dapagliflozin (DFG) in rat plasma. The optimized using three levels three-factor Box–Behnken statistical (BBD). mobile phase composition (acetonitrile % as A), flow rate (mL/min B) UV-wavelength (nm C) selected independent variable whereas area (AU Y1), retention time (min. Y2) tailing factor (% Y3) dependent variables. linearity, sensitivity (LOD & LOQ),...
Long-acting preparations containing the antipsychotic paliperidone for intramuscular injection has drawn considerable attention to achieve harmless long-term treatment. This study aimed develop loaded polycaprolactone (PCL) nanoparticles and investigate influence of PCL/drug ratio, stabilizer type, chitosan coating on physicochemical properties, protein adsorption, cellular toxicity. Results showed that produced enlarged particle sizes, shifted surface charges from negative into positive did...
Luteolin is a natural drug used as an antioxidant and anti-inflammatory, but unfortunately, it possesses low water solubility, which hinders its delivery via the skin. The main objective of this study was to prepare luteolin-loaded nanosuspension by antisolvent precipitation/sonication technique effects four stabilizers (two nonionic stabilizers, Pluronic F127 Tween 80, two polymeric HPMC alginate) on physicochemical properties prepared formulations. selected formulations were incorporated...
Pyrazolopyrimidine heterocycle and its isosteres represent the main scaffold for many pharmacologically active drugs including anti-inflammatory agents. The COX-2 inhibitors are principal gate design of new safe potent Novel derivatives pyrazolo[1,5-a] pyrimidines were synthesized screened in vivo vitro their potential. Within constructed compounds, compound 11 was most on IL-6 TNF-α (percentage inhibition = 80 89%, respectively). In addition, 12 displayed inhibitory effect towards (IC50...
The barrier functionalities of the skin offer a major but not insuperable hindrance for fabrication delivery effective systems. This work aimed to develop an optimized lipid polymer hybrid nanoparticle and assess effectiveness hydrocortisone (9.872 ± 0.361 × 10-3 cm2/h) drug through from formulation when compared with solution. Meanwhile, histological examination after topical application showed safe increase in epidermal thickness. In vivo, promising anti-inflammatory activity croton...