Plants are considered green resources for thousands of bioactive compounds. Essential oils (EOs) an important class secondary compounds with various biological activities, including allelopathic and antimicrobial activities. Herein, the present study aimed to compare chemical profiles EOs widely distributed medicinal plant Calotropis procera collected from Saudi Arabia Egypt. In addition, this also assess their The Egyptian ecospecies were extracted by hydrodistillation analyzed via GC-MS....

Abstract Erigeron bonariensis is widely distributed throughout the world's tropics and subtropics. In folk medicine, E. has historically been used to treat head brain diseases. Alzheimer’s disease (AD) most widespread form of dementia initiated via disturbances in function. Herein, neuroprotective effect chemically characterized ethanolic extract reported for first time an AD animal model. Chemical profiling was conducted using UPLC–ESI-MS analysis. Female rats underwent ovariectomy (OVX)...

New pyrazolylindolin-2-one linked coumarin derivatives were designed as dual BRAF V600E /VEGFR-2 inhibitors targeting melanoma cells A375. Docking simulation showed various interactions with the binding residues in and VEGFR-2 active sites.

Background Diabetes mellitus (DM) poses a major risk to human health due an array of implications, one which is detrimental effect on the testicular and reproductive functions. Euphorbia heterophylla widely recognized for its medicinal properties worldwide. Methods findings The objective this study was profile E . ethanol extract (EH-EtOH) elucidate protective role in oxidative stress, relieving inflammatory action hyperglycemia-induced degeneration restoring normal histological structure...

Abstract Essential oils ( EO s) from the aerial parts of three Launaea species collected two different habitats were extracted [ mucronata coastal desert LMC ) and inland LMD ), nudicaulis LNC LND spinosa LS )]. The s analysed by gas chromatography mass spectrometry GC ‐ MS tested for antioxidant activity as well allelopathic against purslane. A total 117 compounds identified all samples, including 64 , 50 39 24 20 representing 100% oil mass. oxygenated sesquiterpenes major 62.73, 61.02,...

The essential oil (EO) of Xanthium strumarium L. leaves (family: Asteraceae) was extracted by hydrodistillation, and then analyzed gas chromatography-mass spectrometry (GC-MS). Forty-three compounds were identified. sesquiterpenoids represented the major constituents (72.4%), including oxygenated (61.78%) non-oxygenated (10.62%) sesquiterpenes, followed monoterpenes (25.19%). diterpenoids hydrocarbons determined as minor compounds. main EO 1,5-dimethyltetralin (14.27%), eudesmol (10.60%),...

Pulicaria genus (fleabane) is characterized by its fragrant odor due to the presence of essential oil (EO). According literature reviews, EO somalensis O.Hoffm. (Shie) still unexplored. For first time, 71 compounds were in derived from above-ground parts P. collected Saudi Arabia. Sesquiterpenes represented main components (91.8%), along with minor amounts mono-, diterpenes, and hydrocarbons. Juniper camphor (24.7%), α-sinensal (7.7%), 6-epi-shyobunol (6.6%), α-zingiberene (5.8%),...

The variation in habitat has a direct effect on the plants and as consequence, changes their content of bioactive constituents biological activities. present study aimed to explore essential oils (EOs) phenolics Heliotropium curassavicum collected from coastal inland habitats. Additionally, we determined antioxidant allelopathic activity against weed, Chenopodium murale. Fifty-six compounds were identified overall EOs, which 25 components sample, 52 one. Sesquiterpenes main class both...

Launaea nudicaulis is used in folk medicine worldwide to treat several diseases. The present study aimed assess the antidiabetic activity of L. ethanolic extract and its effect on diabetic complications streptozotocin-induced hyperglycemic rats. was orally administrated at 250 500 mg/kg/day for 5-weeks compared glibenclamide as a reference drug dose 5 mg/kg/day. Administration exhibited potential hypoglycemic manifested by significant depletion serum blood glucose concurrent with elevation...

Plants belonging to the Asteraceae family are widely used as traditional medicinal herbs around world for treatment of numerous diseases. In this work, chemical profiles essential oils (EOs) above-ground parts Pluchea dioscoridis (L.) DC. and Erigeron bonariensis were studied in addition their cytotoxic anti-aging activities. The extracted EOs from two plants via hydrodistillation analyzed by gas chromatography-mass spectroscopy (GC-MS). GC-MS EO P. revealed identification 29 compounds...

fruits are grown worldwide for their special nutritive and several health benefits. Among citrus bioactives, naringenin, a major flavanone, exhibits potential hepatoprotective effect that is not fully elucidated. Herein, serum biochemical parameters histopathological assays were used to estimate the activity of isolated from

Catechin is a naturally occurring flavonoid of the flavan-3-ol subclass with numerous biological functions; however, these benefits are diminished due to several factors, including low water solubility and degradation in stomach's harsh environment. So, this study aimed develop an intelligent catechin colon-targeting delivery system high loading capacity. This was done by coating surface-decorated mesoporous silica nanoparticles pH-responsive enteric polymer called Eudragit®-S100. The...

The characteristic chemical composition of Nigella seeds is directly linked to their beneficial properties. This study aimed investigate the phytochemical sativa using a 100% ethanolic extract HPLC-ESI-MS/MS. Additionally, it explored potential biological effects on female rat reproduction. Follicle Stimulating Hormone (FSH), Luteinizing (LH), Estrogen (E2), and Progesterone (P4) hormone levels were also assessed, along with morphological histological ovarian, oviductal, uterine tissues....

Abstract The genus Euphorbia attracted the attention of many researchers worldwide from natural products, bioactivity, and ecological perspective. essential oils (EOs) heterophylla are poorly studied. Therefore, present study aimed to provide a detailed profile E. EOs as well determine their antioxidant allelopathic activities. aerial parts were extracted using hydrodistillation analyzed via GC/MS. activity was determined based on scavenging free radical, 1,1‐diphenyl‐2‐picrylhydrazyl H 2 O...

The essential oil (EO) of Bassia muricata shoots was extracted via hydro-distillation and then investigated by gas chromatography-mass spectrometry. Thirty-four compounds were recognized for the first time from this plant, representing 100% total mass. Terpenoids represented major components with 69.17% mass, containing oxygenated sesquiterpenes (53.18%), monoterpenes (9.77%), sesquiterpene hydrocarbons (5.03%), diterpenes (1.19%). Additionaly, 6-methoxy-1-acetonaphthone only aromatic...

Guava (Psidium guajava) leaves are commonly used in the treatment of diseases. They considered a waste product resulting from guava cultivation. The very rich essential oils (EOs) and volatiles. This work represents detailed comparative chemical profiles EOs derived six varieties cultivated Egypt, including Red Malaysian (RM), El-Qanater (EQ), White Indian (WI), Early (E), El-Sabahya El-Gedida (ESEG), (RI), on same farm Egypt. were extracted by hydro-distillation analyzed with GC-MS....

Invasive species are considered as one of the major threats to ecosystems worldwide. Although invasive plants regarded a foe, they could be natural resources for valuable bioactive compounds. The present study aimed characterize chemical composition essential oil (EO) from plant Argemone ochroleuca Sweet, collected Saudi Arabia, well evaluate its phytotoxic activity. Seventy-four compounds were characterized via GC-MS analysis EO representing 98.75% overall mass. oxygenated constituents...

The exploration of new bioactive compounds from natural resources as alternatives to synthetic chemicals has recently attracted the attention scientists and researchers. To our knowledge, essential oil (EO) Kickxia aegyptiaca not yet been explored. Thus, present study was designed explore EO chemical profile K. for first time, well evaluate its antioxidant antibacterial activities, particularly extracts this plant that have reported possess various biological activities. extracted aerial...