A5070924066- Synthesis and biological activity
- Enzyme function and inhibition
- Synthesis and Catalytic Reactions
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Synthesis and Characterization of Heterocyclic Compounds
- Computational Drug Discovery Methods
- Cancer Mechanisms and Therapy
- Cholinesterase and Neurodegenerative Diseases
- Bioactive Compounds and Antitumor Agents
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical Reactions and Mechanisms
- Click Chemistry and Applications
- Cancer-related Molecular Pathways
- Angiogenesis and VEGF in Cancer
- Essential Oils and Antimicrobial Activity
- Cytokine Signaling Pathways and Interactions
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- PI3K/AKT/mTOR signaling in cancer
- Phytochemicals and Antioxidant Activities
- Research on Leishmaniasis Studies
Kafrelsheikh University
2017-2025
Pharos University in Alexandria
2024-2025
Suez Canal University
2024
Badr University in Cairo
2022-2023
King Salman International University
2023
Egyptian Russian University
2014-2017
National Research Centre
2017
King Saud University
2016
A thiazolidine-2,4-dione nucleus was molecularly hybridised with the effective antitumor moieties; 2-oxo-1,2-dihydroquinoline and 2-oxoindoline to obtain new hybrids potential activity against VEGFR-2. The cytotoxic effects of synthesised derivatives Caco-2, HepG-2, MDA-MB-231 cell lines were investigated. Compound 12a found be most potent candidate investigated IC50 values 2, 10, 40 µM, respectively. Furthermore, tested in vitro for their VEGFR-2 inhibitory showing strong inhibition....
As a progressive neuropathic condition, glaucoma can cause lifelong blindness if left untreated. Novel phenylpyridazine-tethered sulfonamides were designed as selective inhibitors for carbonic anhydrase (CA) isoform II to find effective therapeutic agents glaucoma. Subsequently, the target synthesized and assessed their inhibitory action against cytosolic CA I II. Interestingly, molecules poorly inhibited while exhibiting low subnanomolar potency Compound
Herein, we report the synthesis of different novel sets coumarin-6-sulfonamide derivatives bearing functionalities (4a, b, 8a–d, 11a–d, 13a, and 15a–c), in vitro evaluation their growth inhibitory activity towards proliferation three cancer cell lines; HepG2 (hepatocellular carcinoma), MCF-7 (breast cancer), Caco-2 (colon cancer). cells were most sensitive to influence target coumarins. Compounds 13a 15a emerged as active members against (IC50 = 3.48 ± 0.28 5.03 0.39 µM, respectively). able...
In the current medical era, spirooxindole motif stands out as a privileged heterospirocyclic scaffold that represents core for wide range of bioactive naturally isolated products (such Strychnofoline and spirotryprostatins A B) synthetic compounds. Interestingly, no much attention has been paid to develop derivatives with dual antioxidant anticancer activities. this context, series spirooxindoles 6a-p was examined their effect towards HepG2 hepatocellular carcinoma PC-3 prostate cancer cell...
In connection with our research program on the development of novel anticancer candidates, herein we report design and synthesis series 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas 5a–l. The target pyridins were evaluated for their in vitro activity against two cancer cell lines: non-small lung A549 line colon HCT-116 line. Compound 5l emerged as most active congener towards both lines IC50 values equal to 3.22 ± 0.2 2.71 0.16 µM, respectively, which are comparable those Doxorubicin; 2.93...
Today, skin care products and cosmetic preparations containing natural ingredients are widely preferred by consumers. Therefore, many brands encouraged to offer more the market, such as plant extracts that can be used for their antiaging, antiwrinkle, depigmentation properties other purposes. In current study, volatile constituents of hexane-soluble fraction a Stenocarpus sinuatus (family Proteaceae) leaf methanol extract (SSHF) were analyzed using GC/MS analysis. Moreover, antiaging...
In the current work, we designed and synthesized three families of non-fused fused compounds based on cyanopyridone: derivatives 6-amino-1,2-dihydropyridine-3,5-dicarbonitrile (5a-f) 3,4,7,8-tetrahydro pyrimidine-6-carbonitrile (6a-b 7a-e). The newly compounds' structure were determined using a variety techniques, including 1H NMR, 13C mass spectrum, infrared spectroscopy, elemental analysis. developed tested for ability to inhibit growth breast adenocarcinoma (MCF-7) hepatic (HepG2) cell...
The novel coronavirus disease COVID-19, caused by the virus SARS CoV-2, has exerted a significant unprecedented economic and medical crisis, in addition to its impact on daily life health care systems all over world. Regrettably, no vaccines or drugs are currently available for this new critical emerging human disease. Joining global fight against study we aim at identifying potential inhibitor COV-2 2′-O-methyltransferase (nsp16) which is one of most attractive targets cycle, responsible...
New quinoline and isatin derivatives having the main characteristics of VEGFR-2 inhibitors was synthesised. The antiproliferative effects these compounds were estimated against A549, Caco-2, HepG2, MDA-MB-231. Compounds 13 14 showed comparable activities with doxorubicin Caco-2 cells. These strongly inhibited kinase activity. cytotoxic evaluated Vero Compound 7 highest value safety selectivity. Cell migration assay displayed ability compound to prevent healing abilities in cancer...
The underutilized Amaranthus leafy vegetables are a unique basis of pigments such as β-cyanins, β-xanthins, and betalains with radical scavenging capacity (RSC). They have abundant phytonutrients antioxidant components, pigments, vitamins, phenolics, flavonoids. Eight selected genotypes (four from each species) were evaluated for phytonutrients, flavonoids, antioxidants in randomized complete block design under ambient field conditions three replicates. studied traits showed wide range...
Abstract Currently, the humanity is in a fierce battle against various health-related challenges especially those associated with human malignancies. This created urge to develop potent and selective inhibitors for tumor cells through targeting specific oncogenic proteins possessing crucial roles cancer progression survive. In this respect, new series of pyrazole-thiazol-4-one hybrids ( 9a–p ) were synthesized as potential anticancer agents. All molecules exhibited antiproliferative actions...
In this article, 34 anticoagulant drugs were screened in silico against the main protease (Mpro) of SARS-CoV-2 using molecular docking tools. Idraparinux, fondaparinux, eptifibatide, heparin, and ticagrelor demonstrated highest binding affinities towards Mpro. A dynamics study at 200 ns was also carried out for most promising anticoagulants to provide insights into dynamic thermodynamic properties compounds. Moreover, a quantum mechanical conducted which helped us attest some findings....
A library of modified VEGFR-2 inhibitors was designed as inhibitors. Virtual screening conducted for the hypothetical using in silico docking, ADMET, and toxicity studies. Four compounds exhibited high affinity against an acceptable range drug-likeness. These were synthesised subjected to vitro cytotoxicity assay two cancer cell lines besides inhibitory determination. Compound D-1 showed cytotoxic activity HCT-116 cells almost double that sorafenib. Compounds A-1, C-6, good IC50 values...
We report herein, the design and synthesis of thiazolidine-2,4-diones derivatives as new inhibitors for VEGFR-2. The designed members were assessed their in vitro anticancer activity against four cancer cell lines; A549, Caco-2, HepG-2 MDA-MB-231. Compound 14a showed most potent effects lines (IC50 = 1.5 31.5 μM, respectively). Next, VEGFR-2 inhibitory activity, safety profiles selectivity indices examined all synthesized normal Vero line. (the safest member Caco-2 line) was further...