A5016921887- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Computational Drug Discovery Methods
- Metal complexes synthesis and properties
- Quinazolinone synthesis and applications
- Inorganic and Organometallic Chemistry
- Synthesis and Characterization of Heterocyclic Compounds
- Bioactive Compounds and Antitumor Agents
- Multicomponent Synthesis of Heterocycles
- Phenothiazines and Benzothiazines Synthesis and Activities
- Plant Toxicity and Pharmacological Properties
- Synthesis and Reactivity of Heterocycles
- Thermal and Kinetic Analysis
- Curcumin's Biomedical Applications
- Organometallic Compounds Synthesis and Characterization
- Click Chemistry and Applications
- Cancer Treatment and Pharmacology
- Bee Products Chemical Analysis
- Lung Cancer Treatments and Mutations
- Bone and Joint Diseases
- Photochemistry and Electron Transfer Studies
- Enzyme function and inhibition
- Vanadium and Halogenation Chemistry
- Analytical Chemistry and Chromatography
Taif University
2014-2025
Beni-Suef University
2015-2025
Port Said University
2003-2020
Menoufia University
2019
Suez Canal University
2003-2014
Arish University
2014
Kafrelsheikh University
2014
Aswan University
1991-1995
University of Glasgow
1989
A new series of pyrimidine-5-carbonitrile derivatives has been designed as ATP mimicking tyrosine kinase inhibitors the epidermal growth factor receptor (EGFR).
Guided by the structural optimization principle and promising anticancer effect of quinoxaline nucleus, a new series novel HDAC inhibitors were designed synthesized. The synthesized compounds to bear reported pharmacophoric features in addition an extra moiety occupy non-used vacant deep pocket receptor. newly prepared evaluated for their vitro anti-proliferative activities against HepG-2 HuH-7 liver cancer cell lines. tested showed both most active ten candidates ( 6 c , d f g k l 7 b 8 10...
In this article, 34 anticoagulant drugs were screened in silico against the main protease (Mpro) of SARS-CoV-2 using molecular docking tools. Idraparinux, fondaparinux, eptifibatide, heparin, and ticagrelor demonstrated highest binding affinities towards Mpro. A dynamics study at 200 ns was also carried out for most promising anticoagulants to provide insights into dynamic thermodynamic properties compounds. Moreover, a quantum mechanical conducted which helped us attest some findings....
A new series of 1H-pyrrole (6a-c, 8a-c), pyrrolo[3,2-d]pyrimidines (9a-c) and pyrrolo[3,2-e][1, 4]diazepines (11a-c) were designed synthesised. These compounds to have the essential pharmacophoric features EGFR Inhibitors, they shown anticancer activities against HCT116, MCF-7 Hep3B cancer cells with IC50 values ranging from 0.009 2.195 µM. value doxorubicin is 0.008 µM, 9a 9c showed 0.011 µM respectively HCT-116 cells. Compound 8b exerted broad-spectrum activity all tested cell lines an...
Keratoconus (KC) is a serious disease that can affect people of any race or nationality, although the exact etiology and pathogenic mechanism are still unknown. In this study, thirty-two FDA-approved ophthalmic drugs were exposed to virtual screening using docking studies against both MMP-2 MMP-9 proteins find most promising inhibitors as proposed computational treat keratoconus. Matrix metalloproteinases (MMPs) zinc-dependent proteases, MMP (MMPIs) usually designed interact with zinc ion in...
Diabetes mellitus (DM) is the most prevalent cause of diabetic retinopathy (DRP). DRP has been recognized for a long time as microvascular disease. Many drugs were used to treat DRP, including vildagliptin (VLD). In addition its hypoglycemic effect, VLD minimizes ocular inflammation and improves retinal blood flow individuals with type 2 diabetes mellitus. Nevertheless, can upper respiratory tract infections, diarrhea, nausea, hypoglycemia, poor tolerability when taken orally regularly due...
In continuation of our previous work on the design and synthesis topoisomerase II (Topo II) inhibitors DNA intercalators, a new series quinoxaline derivatives were designed synthesized. The synthesized compounds evaluated for their cytotoxic activities against panel three cancer cell lines (Hep G-2, Hep-2, Caco-2). Compounds 18b, 19b, 23, 25b, 26 showed strong potencies all tested with IC50 values ranging from 0.26 ± 0.1 to 2.91 µM, comparable those doxorubicin (IC50 0.65 0.81 µM). most...
In recent years, suppressing tubulin polymerization has been developed as a therapeutic approach for cancer treatment. Thus, new derivatives based on thiazol-5(4H)-ones have designed and synthesized in an eco-friendly manner. The the same essential pharmacophoric features of colchicine binding site inhibitors. anti-proliferative activity was evaluated three human cell lines (HCT-116, HepG-2, MCF-7) using MTT assay procedure used positive control. Compounds 4f, 5a, 8f, 8g, 8k showed superior...
Tolmetin sodium (TLM) is a non-steroidal anti-inflammatory drug (NSAIDs). TLM used to treat inflammation, skeletal muscle injuries, and discomfort associated with bone disorders. Because of the delayed absorption from gastro intestinal tract (GIT), currently available dosage forms have rather protracted start effect, according pharmacokinetic studies. The aim this study was create combination for fast dissolving tablets (TLM-FDT) that would boost drug's bioavailability by increasing...
Proceeding our prior studies of SARS-CoV-2, the inhibitory potential against SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) has been investigated for a collection 3009 clinical and FDA-approved drugs. A multi-phase in silico approach employed this study. Initially, molecular fingerprint experiment Remdesivir (RTP), co-crystallized ligand examined protein, revealed most similar 150 compounds. Among them, 30 compounds were selected after structure similarity experiment. Subsequently, docked...
Novel pyrrolo [2,3-b] pyrrole derivatives were synthesized and their hypolipidemic activity was assessed in hyperlipidemic rats. The chemical structures of the new confirmed through spectral analysis. Compounds 5 6 revealed to be most effective agents, with considerable hypocholesterolemic hypotriglyceridemic effects. They appear promising candidates for creating powerful anti-atherosclerotic properties. As antimicrobial activity, some tested compounds showed moderate against Pseudomonas...
Gefitinib (GFT) is a tyrosine kinase inhibitor drug used as first-line treatment for patients with advanced or metastatic non-small cell lung, colon, and breast cancer. GFT exhibits low solubility hence oral bioavailability, which restricts its clinical application. One of the most important trends in overcoming such problems use vesicular system. Cubosomes are considered one systems to improve bioavailability. In this study, cubosomal nanoparticles (GFT-CNPs) were prepared by emulsification...