A5034807820- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Nanoparticles: synthesis and applications
- Ziziphus Jujuba Studies and Applications
- Alkaloids: synthesis and pharmacology
- Enzyme function and inhibition
- Phytochemicals and Medicinal Plants
- Ocular Surface and Contact Lens
- Antioxidant Activity and Oxidative Stress
- Bioactive Compounds and Antitumor Agents
- Microbial Natural Products and Biosynthesis
- Chemical Reaction Mechanisms
- Computational Drug Discovery Methods
- Chromatography in Natural Products
- Fungal Biology and Applications
- Asthma and respiratory diseases
- Protease and Inhibitor Mechanisms
- Hops Chemistry and Applications
- Wound Healing and Treatments
- Insect Pest Control Strategies
- Quinazolinone synthesis and applications
Badr University in Cairo
2022-2024
Keratoconus (KC) is a serious disease that can affect people of any race or nationality, although the exact etiology and pathogenic mechanism are still unknown. In this study, thirty-two FDA-approved ophthalmic drugs were exposed to virtual screening using docking studies against both MMP-2 MMP-9 proteins find most promising inhibitors as proposed computational treat keratoconus. Matrix metalloproteinases (MMPs) zinc-dependent proteases, MMP (MMPIs) usually designed interact with zinc ion in...
Abstract To exploit the advantageous properties of approved drugs to hasten anticancer drug discovery, we designed and synthesized a series fluoroquinolone (FQ) analogs via functionalization acid hydrazides moxifloxacin, ofloxacin, ciprofloxacin. Under NCI-60 Human Tumor Cell Line Screening Assay, ( IIIf ) was most potent among moxifloxacin derivatives, whereas VIb only ofloxacin derivative with significant effects ciprofloxacin derivatives were devoid activity. further selected for...
This research work aimed to identify the main components that are responsible for sedative properties of hop cones and allocate their targets. investigation was performed through molecular docking, dynamic simulations, root mean square fluctuation (RMSF) analysis, DFT calculation techniques. The tested compounds from
Diabetic foot ulceration is a common complication of an uncontrolled diabetic regimen and considered serious type wound. Matrix metalloprteinases (MMPs) are the key enzymes in wound management, overexpression MMPs can lead to chronic wounds ulcers. Calendula officinalis extract has established its efficacy treating folk medicine. In this research work, we will focus on chemical constituents promising herb investigate abilities target matrix metalloprteinase-8 (MMP-8) metalloprteinase-9...
New pyrrolidine derivatives with more than 50% structural similarity captopril were designed to get new mimics superior potential act on both peripheral and central ACE. Further optimization was carried out through pharmacophoric mapping, then pharmacokinetics of these compounds analyzed, 42 selected for further study, as they exhibited pass BBB. Molecular docking ACE using lisinopril reference drugs performed, Compound 28 (2-Pyrrolidin-2-ylidene-N-thiomorpholin-4-ylmethyl-malonamic acid...
Continuous scientific research is necessary to help in the discovery of new promising remedies for treatment COVID-19, caused by SARS-CoV-2 virus. This current was aimed at identifying potential novel inhibitors main protease, which represents one most important targets viral life cycle. Protein data bank file ID: 7JQ2 used containing co-crystallized inhibitor MPI5 with Main protease. A virtual screening process natural evodiamine compounds performed through absorption, distribution,...