A5023728511- Analytical Chemistry and Chromatography
- Synthesis and biological activity
- Cancer survivorship and care
- Synthesis and Characterization of Heterocyclic Compounds
- Analytical Methods in Pharmaceuticals
- Adsorption and biosorption for pollutant removal
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Nanomaterials for catalytic reactions
- Phytochemicals and Antioxidant Activities
- Synthesis and Biological Evaluation
- Chromatography in Natural Products
- Phytochemistry and Biological Activities
- Quinazolinone synthesis and applications
- COVID-19 Clinical Research Studies
- Protein purification and stability
- Microfluidic and Capillary Electrophoresis Applications
- Essential Oils and Antimicrobial Activity
- Heme Oxygenase-1 and Carbon Monoxide
- Machine Learning in Bioinformatics
- Click Chemistry and Applications
- Drug Solubulity and Delivery Systems
- Food Chemistry and Fat Analysis
- Advanced Photocatalysis Techniques
- Curcumin's Biomedical Applications
Taif University
2020-2025
Niger State Polytechnic
2015
University of Strathclyde
2011-2014
In addition to the pathogenesis of SARS-CoV-2, bacterial co-infection plays an essential role in incidence and progression SARS-CoV-2 infections by increasing severity infection, as well disease symptoms, death rate antimicrobial resistance (AMR). The current study was conducted a tertiary-care hospital Lahore, Pakistan, among hospitalized COVID-19 patients see prevalence co-infections AMR rates different isolated bacteria. Clinical samples for laboratory diagnosis were collected from 1165...
Keratoconus (KC) is a serious disease that can affect people of any race or nationality, although the exact etiology and pathogenic mechanism are still unknown. In this study, thirty-two FDA-approved ophthalmic drugs were exposed to virtual screening using docking studies against both MMP-2 MMP-9 proteins find most promising inhibitors as proposed computational treat keratoconus. Matrix metalloproteinases (MMPs) zinc-dependent proteases, MMP (MMPIs) usually designed interact with zinc ion in...
Abstract New piperazine–chalcone hybrids and related pyrazoline derivatives have been designed synthesised as potential vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors. The National Cancer Institute (NCI) has selected six compounds to evaluate their antiproliferative activity in vitro against 60 human cancer cells lines. Preliminary screening of the examined indicated promising anticancer number cell enzyme inhibitory VEGFR-2 was evaluated IC50 tested ranged from 0.57 µM...
The global outbreak of the COVID-19 pandemic provokes scientists to make a prompt development new effective therapeutic interventions for battle against SARS-CoV-2. A series
Hyperlipidemia is still the leading cause of heart disease in patients with hypertension. The purpose this study to make rosuvastatin calcium (ROS) and atenolol (AT) bilayer tablets treat coexisting dyslipidemia hypertension a single product. ROS was chosen for immediate-release layer constructed tablets, whereas AT sustained-release layer. solid dispersion sorbitol (1:3 w/w) utilized while hydroxypropyl methylcellulose (HPMC), ethylcellulose (EC), sodium bicarbonate were incorporated into...
This study examined the protective effect of quercetin against high‐altitude‐induced brain damage in rats. A molecular docking was performed to investigate potential reducing damages through its ability target oxidative stress enzymes. Biomarker assessment screening assays were also then followed by vivo studies. Three groups rats divided into control group, an untreated animal model group with induced damage, and finally, treated that received dose equal 20 mg/kg their body weights....
Medicinal plants play important role in the public health sector worldwide. Natural products from medicinal are sources of unlimited opportunities for new drug leads because their unique chemical diversity. Researchers have focused on exploring herbal as potential treatment cancer, cardiac and infectious diseases. Arisaema flavum (Forssk.) is an plant found northwest Himalayan regions Pakistan. It a poisonous used remedy against snake bites scorpion stings. In this study, two bioactive...
The analytical chemistry community is attempting to incorporate green concepts in the development of techniques redefine methods and dramatically modify philosophy technique development. Each greenness assessment method has its own benefits drawbacks, as well procedures. results each produce numerous deductions regarding selection a greenest chromatographic on which determination tool depends. current study examined behavior 26 reported literature for evaluation medicine empagliflozin using...
In the last few decades, Alzheimer’s disease (AD) has emerged as a serious global problem, and it been considered most common type of dementia. PPAR γ beta-secretase 1 (BACE1) are potential targets for management. same time, sulfonylureas sulfonamides have confirmed to agonistic activity. Aiming obtain new anti-AD agents, thirty-five compounds sulfonamide sulfonylurea derivatives having essential pharmacophoric features reported agonists subjected virtual screening. Docking studies revealed...
A novel adsorbent, amine-functionalized porous silica-coated iron oxide nanoparticles (Fe3O4@SiO2-NH2) was prepared for the removal of cefixime (CFX) and ceftriaxone (CFT) from water. The adsorbent then characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy, transmission particle size, surface area pore size analysis. amine functionalized silica coated are 110 nm, 1073 m2/g 40 Å, respectively. effect dose, concentration, time duration, temperature pH...
A novel HPLC chromatographic method was established for the concurrent analysis of Lamivudine (LAM), Zidovudine (ZID), and nevirapine (NEV) in powder form pharmaceuticals.The has advantages over old published methods terms simplicity sensitivity.A Phenomenex ODS stationary phase an isocratic elution system, with a running mobile containing 0.2M Ammonium acetate (controlled to pH 3.5 via diluted H 3 PO 4 acid), methanol, acetonitrile (50: 30: 20, by volume) applied optimum resolution...
Abstract On March 11 th , 2020, the World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) a pandemic. To control pandemic, billions of vaccine doses have been administered worldwide. Predictors COVID-19 vaccine-related side effects are inconsistently described in literature. This study aimed to identify predictors effects’ severity after vaccination among young adult students at Taif University (TU) Saudi Arabia. An online, anonymous questionnaire was used. Descriptive...
With 19.3 million new cases and almost 10 deaths in 2020, cancer has become a leading cause of death today. Curcumin its analogues were found to have promising anticancer activity. Inspired by curcumin’s activity, we prepared three semi-synthetic chemically modifying the diketone function curcumin pyrazole counterpart. The (3a−c) synthesized two different methods, followed their DFT analyses study HOMO/LUMO configuration access stability compounds (∆E = 3.55 3.35 eV). tested for...
In this study, bacteria Bacillus cereus and xiamenensis were used for the biosorption of Cd (II) Cr (VI) from wastewater. The effects contact time, pH, metal ion concentration on studied. minimum inhibitory (MIC) exhibited by was 6 mM 7 (VI), that 8 (VI). achieved a maximum uptake 90.70% 84.32% (II), while 96.87% 92.15% in 60 min. adsorption capacities 150.02 201.2 mg/g, respectively, values 180.76 273.49 mg/g respectively. isotherm study showed data fitted well with Freundlich model....
Separation with high efficiency and good resolution is constantly in demand the pharmaceutical industry. The fast efficient separation of complex samples such as peptides proteins a challenging task. To achieve resolution, chromatographers are moving towards small particles packed into narrow-bore columns. Silica monolith (sub-2 µm) were derivatized chlorodimethyl octadecyl silane (C18) stainless steel columns (100 mm × 1.8 i.d) by slurry-packing method. developed used for proteins. A (N)...
Abstract Being the second major cause of death worldwide, lung cancer poses a significant threat to health patients. This worsened during era pandemic since is found be more prone SARS-CoV-2 infection. Many recent studies imply high frequency COVID-19 infection associated severe outcome. However, molecular are still lacking in this respect. Hence current study designed investigate binding affinities ACE2 mutants with viral spike protein find susceptibility respective carrying patients...
Abstract A new labdane diterpene characterized as 18α- O - trans p -feruloyl-15-methyl-8(17)-labdanoate has been isolated from the roots of Vachellia nilotica . Also were -coumaric acid, ferulic stearic lupeol, and a mixture β-sitosterol stigmasterol. The compounds obtained after series column chromatography on silica gel, their structures elucidated using NMR LC-MS analyses. showed good anti-parasitic activity with an IC 50 0.0177 µM against Trypanosoma brucei 0.0154 Leishmania major Alamar...