A5100744234- Bacterial biofilms and quorum sensing
- Garlic and Onion Studies
- Flowering Plant Growth and Cultivation
- Chronic Lymphocytic Leukemia Research
- Structural Behavior of Reinforced Concrete
- Phytochemicals and Antioxidant Activities
- Plant Physiology and Cultivation Studies
- Hepatitis C virus research
- Artificial Immune Systems Applications
- Hydraulic Fracturing and Reservoir Analysis
- Plant Growth Enhancement Techniques
- Reservoir Engineering and Simulation Methods
- Medicinal Plants and Neuroprotection
- Advanced Malware Detection Techniques
- MicroRNA in disease regulation
- COVID-19 diagnosis using AI
- Agricultural Science and Fertilization
- Heart Failure Treatment and Management
- Antimicrobial Peptides and Activities
- Digital Imaging for Blood Diseases
- Fungal and yeast genetics research
- Extracellular vesicles in disease
- Insect Resistance and Genetics
- Acute Myeloid Leukemia Research
- Structural Load-Bearing Analysis
Imam Mohammad ibn Saud Islamic University
2022-2025
Al-Azhar University
2025
Beni-Suef University
2025
Islamic University
2024
Ain Shams University
2015-2024
New Valley University
2020-2024
Benha University
2024
The Ohio State University
2024
South Valley University
2020-2024
Zagazig University
2024
The development of bacterial resistance to antibiotics is an increasing public health issue that worsens with the formation biofilms. Quorum sensing (QS) orchestrates virulence and controls biofilm. Targeting promising approach overcome increment antibiotics. In a previous detailed in silico study, anti-QS activities twenty-two β-adrenoreceptor blockers were screened supposing atenolol as candidate. current study aims evaluate anti-QS, anti-biofilm anti-virulence blocker against...
Protecting food from bacterial contamination is crucial for ensuring its safety and avoiding foodborne illness. Serratia marcescens one of the contaminants that can form biofilms pigments spoil product could cause infections illness to consumer. Food preservation essential diminish such or at least reduce their pathogenesis; however, it should not affect odor, taste, consistency must be safe. Sodium citrate a well-known safe additive current study aims evaluate anti-virulence anti-biofilm...
Summary. There is debate in the literature about frequency and importance of delayed transfusion reactions. This uncertainty could reflect endpoints used (clinical or serological) type study (typically retrospective case series). In this report we describe a prospective investigation to determine alloimmunization post whether alloantibody production laboratory event has clinical relevance. A total 2490 patients were transfused 11218 red cell concentrates. One more blood samples collected...
Three novel series of pyridine derivatives, namely Schiff's bases, 4-thiazolidinones and azetidin-2-ones bearing pyrazolo[3,4-b]pyridine moiety, have been synthesized. The chemical structures the synthesized compounds were characterized. tested for their antimicrobial activity using agar well diffusion broth macrodilution methods. also evaluated antiproliferative sulforhodamine B (SRB) assay. majority exhibited slight to high against test microorganisms with minimum inhibitory concentrations...
Background: Data from previous studies on the role of inflammatory cytokines as biomarkers for diabetic kidney disease (DKD) are contradictory. The association a particular cytokine single nucleotide polymorphism (SNP) with susceptibility to DKD has not been consistently replicated. We aimed investigate utility in type 2 diabetes mellitus (T2DM) patients. Association gene SNPs development was also explored.Subjects and Methods: One hundred fifty-nine Kuwaiti subjects were recruited this...
The development of bacterial resistance is an increasing global concern that requires discovering new antibacterial agents and strategies. Bacterial quorum sensing (QS) systems play important roles in controlling virulence, their targeting could lead to diminishing pathogenesis. In this context, QS without significant influence on growth assumed as a promising strategy overcome development. This study aimed at evaluating the anti-QS anti-virulence activities β-adrenoreceptor antagonist...
Background P. aeruginosa , a significant bacterium, can cause severe illness and resistance to antibiotics. Quorum sensing (QS) systems regulate virulence factors production. Targeting QS could reduce bacteria pathogenicity prevent antibiotic resistance. Cruciferous vegetables contain sulforaphane, known for its anti-inflammatory, antioxidant, anticancer, antimicrobial properties. Aim We aimed examine the inhibitory influences of at sub-inhibitory concentration (¼ minimum concentration,...
The problem of antibiotic resistance is a global critical public health concern. In light the threat returning to pre-antibiotic era, new alternative approaches are required such as quorum-sensing (QS) disruption and virulence inhibition, both which apply no discernible selective pressure on bacteria, therefore mitigating potential for development resistant strains. Bearing in mind significant role QS orchestrating bacterial virulence, disrupting becomes essential effectively diminishing...
Abstract Background Candida albicans is the most common fungus that causes vaginal candidiasis in immunocompetent women and catastrophic infections immunocompromised patients. The treatment of such hindered due to increasing emergence resistance azoles C. . New approaches are needed combat especially dwindled supply new effective safe antifungals. mainly attributed export outside cells by means efflux pump confers cross all including fluconazole (FLC). Objectives This study aimed investigate...
Human immunodeficiency virus (HIV) and hepatitis C (HCV) infections represent critical global health challenges due to the high morbidity mortality associated with co-infections. HIV, causative agent of acquired syndrome (AIDS), infects 4,000 people daily, potentially leading 1.2 million new cases by 2025, while HCV chronically affects 58 people, causing cirrhosis hepatocellular carcinoma. Indole-based compounds play a crucial role in antiviral drug development their "privileged scaffold"...
In the current research, we examined effects of warfarin (W1 = 5 mg/L and W2 25 mg/L) tinzaparin (T1 T2 on meiofauna using microcosms. These microcosms were intentionally contaminated with both anticoagulants for one month. The findings indicated that nematodes amphipods demonstrated greatest resistance to two evaluated. Specifically, number increased after exposure treatment included T2. Following separate introduction each drug, displayed a taxonomic restructuring, more significant impact...