Diabetes mellitus (DM) is the most prevalent cause of diabetic retinopathy (DRP). DRP has been recognized for a long time as microvascular disease. Many drugs were used to treat DRP, including vildagliptin (VLD). In addition its hypoglycemic effect, VLD minimizes ocular inflammation and improves retinal blood flow individuals with type 2 diabetes mellitus. Nevertheless, can upper respiratory tract infections, diarrhea, nausea, hypoglycemia, poor tolerability when taken orally regularly due...

Helicobacter pylori (H. pylori) plays a crucial role in the pathogenesis of gastritis, peptic ulcer, and gastric cancer. The presence pathogenicity islands (PAI) genes contributes to many gastrointestinal disorders. Cytotoxin-associated gene A (cagA) vacuolating cytotoxin (vacA) are most known virulence H. pylori. So, our aim was study genes’ disorders pathogenesis. Our included 150 adult patients who suffered dyspeptic symptoms were referred GIT endoscopy unit. Gastric biopsies attained for...

Introduction: The increasing incidence of methicillin resistance among Staphylococci has led to renewed interest in the usage macrolide-lincosamide-streptogramin B (MLSB) antibiotics treat S. aureus infections, with clindamycin being preferable agent owing its excellent pharmacokinetic properties. Inducible my lead therapeutic failure.
 Aim: Detection prevalence constitutive and inducible clinical isolates improve outcomes patients.
 Methodology: A total 176 non-duplicate...

Health care workers (HCWs) are frontliners in facing Cornoravirus disease (COVID-19) and hence amongst the high risk groups of acquiring COVID-19 infection. The impact infection post-infection sequelae on work performance has deleterious effects HCWs whole community. aim current study is to assess particularly those with post-COVID-19 syndrome among determine if a possible relationship antibody response exists.A sample 69 previously PCR-positive health matched another group control...

The current study addressed work-related stress and burnout experienced by health care workers (HCWs) in Cairo University isolation hospital its impact on the cognitive domain of their executive functioning.Arabic validated questionnaires Beverly Potter for sources Maslach Burnout Inventory Human Services Survey evaluation degree 81 HCWs were used. Wisconsin Card Sorting Test was used to examine functioning during work 2 weeks after home isolation.A high evident a score questionnaire with...

Using chromium and nickel for electroplating is important in many industries. This process induces variable adverse health effects among exposed workers. The aim of this study to detect the genotoxic combined exposure was conducted on 41 male workers occupationally section a factory compared nonexposed individuals, where full history clinical examination were performed. Laboratory investigations included measurement serum chromium, nickel, 8-hydroxydeoxyguanosine (8-OHdG), micronuclei...

Increasing body mass index (BMI) has reached epidemic proportions globally and recently emerged as strong, independent risk factors for chronic kidney disease (CKD). We conducted this study to verify the prevalence of obesity associated developing CKD among 3000 Egyptian students. The World Health Organization classification BMI categorized population into 1-5 groups, 1146 subjects with normal (20-25), 951 25-29.9, 540 30-34.9, 225 35-39.9, 138 above 40. participants were subjected clinical...

Snakebite is a significant public health issue in which venom-induced consumption coagulopathy common and serious complication that results from the activation of coagulation pathway by snake toxins. We report male patient, 56 y old, who was thought to have been bitten on his left foot. He transported nearby hospital where he received analgesics 3 polyvalent antivenom vials, then our after 12 h. presented with 2 small puncture wounds, pain, blistering, edema On 2nd day, patient developed...

The objective of this population-based study was to estimate the liver morbidity attributable Schistosoma mansoni infection by ultrasonography adopting proposed standard protocols Cairo Meeting on Ultrasonography, 1991. We examined 2384 individuals representing 20% households rural population Ismailia Governorate, East Delta, Egypt. Prevalence S. and haematobium infections were 40.3% 1.7% respectively. Portal tract thickening (PTT) grade 1, 2 3 considered diagnostic schistosomal detected in...

Accumulating evidence indicates the implication of microRNAs (miRs) in cutaneous and hair follicle immunobiology. We evaluated, for first time, miR-17-92a-1 cluster host gene (MIR17HG) expression peripheral blood 248 unrelated alopecia areata (AA) patients compared to 244 matched controls using Real-Time qPCR. also tested its association with different rs4284505A>G genotypes (based on TaqMan allelic discrimination PCR) available clinical data. The adjusted odds ratio (OR) 95% confidence...

Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease characterized by wide spectrum of clinical manifestations with varying severity. The dysregulation cytokines contributes strongly to pathogenesis. Recently, it has been shown that the imbalanced antagonist/agonist profile interleukin (IL)-36 cytokines, might play role in disorders. Our aim investigate mRNA expression Interleukin-36α (IL-36α) peripheral blood Egyptian patients and its association activity organs...

Abstract Background Nutritional status and physical activity are essential to maintain a strong immune system. No definite pharmacological strategies for Coronavirus disease 2019 treatment presently available, so natural enhancement of the system is in need. Our goal was assess correlation healthy diet on COVID-19 outcome. Methods This cohort study conducted 68 adult patients who contracted mild (38) or moderate [30] cases COVID-19, recruited via convenience sampling technique from...

There is a pressing need to find reliable biomarkers for the early diagnosis of silica-induced nephropathy. Abundant genes are upregulated in damaged kidneys with subsequent protein products appearing urine. Liver-type fatty acid-binding (L-FABP) and kidney injury molecule-1 (KIM-1) among most promising. Our objective was study importance L-FABP KIM-1 their urinary proteins detection renal injury, as compared other conventional biomarkers. A cross-sectional conducted 90 pottery workers...

Work zone length in the highways' resurfacing is an important factor that should be determined before start of work. This influences time and cost project. paper presents a framework dedicated for determining optimum highway work zone. The estimates total duration by conducting simulation analysis to model operations highways account associated uncertainties. analyzes divides them into zones. lengths these zones depend on minimum duration. consists two modules; optimization. Simulation...

Type 2 diabetes mellitus (T2DM) represents a serious public health problem. Environmental toxins, other than infectious agents or exposures can stimulate immune responses which are associated with the occurrence of T2DM. Diabetic nephropathy (DN) is complication that leads to changes in structure and function kidneys. The study aimed detect diagnostic biomarkers for (DN), at an early stage, prevent disease progression these patients improve their outcomes.This was performed on 102 T2DM 80...

Escherichia coli (E. coli) is a Gram-negative bacterium that facultative anaerobic in nature. E. strains causing urinary tract infection (UTI) are called uropathogenic (UPEC). UPEC makes up to 70-95% of UTIs. UTI serious health problem concerning antibiotic resistance and biofilms formation. Biofilm can restrict the diffusion antimicrobials. Aim: To detect biofilm producers improve prognosis treatment reduce morbidity mortality rates due UTI. Methods: Forty-seven clinical isolates...

Introduction: Coinage industry is an industrial facility which manufactures coins that can be used as currency. Many metals are in this as: Copper, Aluminum, Nickel, Zinc, Silver, and Gold. Aim of Work: To study the health hazards among workers engaged manufacture coinage with special emphasis on effects due to exposure Copper Aluminum.Materials Methods: The population consisted forty-two personnel one factory Cairo /Egypt were exposed copper aluminium; a comparison group 42 no . A medical...

Abstract Artificial neural networks (ANNs) are biologically inspired algorithms designed to simulate the way in which human brain processes information. In sample preparation for bioanalysis, liquid–liquid extraction (LLE) represents an important step with solvent selection is key laborious step. current work, a robust and reliable ANNs model LLE prediction was generated could predict suitable analyte extraction. The developed takes set of chosen descriptors cited as input predicts...