Diabetes mellitus (DM) is a metabolic disorder resulting from hyperglycemia. Hyperglycemia contributes to oxidative stress, and the release of advanced glycation end products (AGEs) further promotes disease pathogenesis. Uncontrolled diabetes reflects great oral complications affects human health. So, present study aimed assess effects photobiomodulation therapy (PBMT) Metformin on proliferation viability periodontal ligament stem cells (HPDLSCs) cultured in high glucose medium.HPDLSCs were...

Hepatocellular carcinoma is a major health problem worldwide especially in Egypt. It accounts for the fifth common cancer and second cause of death among different cancers. This study investigated efficacy molecular mechanism Nisin and/or Thioridazine as anticancer treatment on human liver HepG2 cell line.Nisin were applied 24 h line (HepG2). 3-(4, 5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was done to assess cytotoxicity Thioridazine. Quantitative reverse...

Circular RNA-HIPK3 (CircHIPK3) has been shown to be aberrantly expressed in a variety of diseases, contributing disease initiation and progression. The aim the present study is investigate role circHIPK3 RNA/microRNA-124a interaction pathogenesis rheumatoid arthritis (RA).This included 79 RA patients 30 control individuals. involved were classified according activity score (DAS28) into mild (24 patients), moderate severe (31 patients). Serum samples collected estimate relative gene...

Abstract (1) Background Human periodontal ligament stem cells (HPDLSCs) are a unique population of mesenchymal (MSCs). Recently, the positive effects photobiomodulation on regulation MSCs proliferation and osteogenic differentiation have gained significant attention. This study aimed to assess vitamin D (as an anabolic factor) HPDLSCs for bone regeneration. (2) Methods were collected, isolated, characterized then divided into six groups: groups I II, control (10 −7 Mol) D, respectively;...

The Emerging Role of Circular RNA Homeodomain Interacting Protein Kinase 3 and 0046367 through Wnt/Beta-Catenin Pathway on the Pathogenesis Nonalcoholic Steatohepatitis in Egyptian Patients

Background Cardiovascular diseases (CVD) represent one of the major sequelae obesity. On other hand, relationship between bone and obesity remains unclear. An increasing number biological epidemiological studies suggest presence a link atherosclerosis osteoporosis, however, precise molecular pathways underlying this close association remain poorly understood. The present work thus aimed to study Matrix Metalloproteinase 9 (MMP-9), as proposed osteoporosis in high fat diet fed rats. Methods...

The main aim of this study was to assess the expression level circulating long non-coding RNA maternally expressed gene 3 (lncRNA-MEG3), microRNA (miR-125a-5P), chemokine C-X-C motif ligand13 (CXCL13), and nuclear factor kappa-light-chain-enhancer activated B cells (NF-kB) in immune thrombocytopenia (ITP) cases its relation disease severity treatment response. This case-control included 45 patients newly diagnosed as ITP healthy subjects. We assessed complete blood count, antinuclear...

The present study was conducted to investigate the role of vitamin C versus platelet-rich plasma (PRP) against sodium fluoride (NaF)-induced cardiotoxicity and cell death in rats' myocardium. Previous studies suggest that NaF decreased cellular viability intracellular antioxidant power.The revealed administration caused histological alterations cardiac muscle increased accumulation reactive oxygen species, expression inducible nitric oxide synthases proliferating nuclear antigen as well...

Haloperidol decanoate (HD) was implicated in cognitive impairment. Agomelatine (AGO) claimed to improve cognition. We aimed at investigating the effects of HD + low- or high- dose AGO on cognition, verifying melatonergic/dopaminergic-to-the cholinergic hypothesis cognition and exploring relevant cardiovascular issues adult male <i>Wistar</i> albino rats. prolonged step through latency <i>by +61.47% (</i><i>ρ &lt; </i><i>0.0001),</i> increased time spent bright light +439.49%...

Background Diabetes mellitus (DM) is a well-known metabolic syndrome characterized by hyperglycemia produced defect in insulin synthesis, action, or combination of the two. Objective The aim this work was to find out how circular RNA 0056618 (circRNA 0056618) interacts with miRNA-206 control blood sugar levels type-2 diabetes (T2DM), as well test role PTPN-1 gene expression and protein phosphatase-2 (PP2A), receptor substrate (IRS) level diabetes. Also, whether circRNA 0056618, miRNA-206,...

The relationship between phthalate exposure and coronary heart disease (CHD) is still unclear. This study aimed to investigate the association CHD determine possible atherogenic mechanisms of phthalates by assessing oxidative stress altering miRNA expression. case-control included 110 participants (55 patients 55 healthy controls). levels markers, malondialdehyde (MDA), superoxide dismutase (SOD), expression miRNA-155 (miR-155) miRNA-208a (miR-208a), were measured correlated with urinary...

Occupational stress is a major health problem among nurses. Critical care nurses appear to experience more at work compared others. Stress associated with multiple system disorders, hormonal, and immunological disturbances, genetic effects. The aim of our study was the detection effects work-related investigate link between immune response, alterations hormones, expression micro-RNA (miRNA) critical An exposed 80 matched controls were involved in study. Full history, psychological assessment...

Introduction: The regeneration of dental pulp tissue using human stem cells (HDPSCs) has attracted increasing attention in recent years. Recent studies have suggested that several factors such as photobiomodulation (PBM) and vitamin D affect the proliferation differentiation HDPSCs. Therefore, present study evaluated effects PBM on odontogenic HDPSCs for dentin -like formation. Methods: were collected, isolated, characterized then divided into six groups: group I, control; II, (10-7 Mol);...

Background We speculated impacts of BM-MSCs and UC-EPCs on reversal hepatic injury induced by carbon tetrachloride (CCl4). Fifty adult rats were divided into five groups: control group, CCl4A CCl4B CCl4/BM-MSCs group CCl4/UC-EPCs group. Blood samples driven to measure concentration albumin ALT. Quantitative expression HGF, TGF-β, MMP-2, VEGF assessed PCR. Histological immunohistochemistry examination the liver tissue performed.Results There was elevating (p < .05) reducing ALT concentrations...

The clinical effect of photodynamic therapy (PDT) may be correlated with the degree dysplasia cancer tissues. aim this study was to compare effects cisplatin, silver nanoparticles (AgNps), and using methylene blue (MB) photosensitizer on Head Neck squamous cell carcinoma - line (HNSCC), Hep-2, through genes expression.Hep-2 cells were divided into four groups: group I as control without any treatment, II III treated by cisplatin AgNps, respectively, IV incubated MB for minutes followed PDT...

There is a pressing need to find reliable biomarkers for the early diagnosis of silica-induced nephropathy. Abundant genes are upregulated in damaged kidneys with subsequent protein products appearing urine. Liver-type fatty acid-binding (L-FABP) and kidney injury molecule-1 (KIM-1) among most promising. Our objective was study importance L-FABP KIM-1 their urinary proteins detection renal injury, as compared other conventional biomarkers. A cross-sectional conducted 90 pottery workers...

Objective: To assess the effect of application Biodentine (BD), Photobiomodulation (PBM) using 810 nm diodelaser and both on proliferation odontogenic differentiation human dental pulp stem cells (HDPSCs).Material Methods: HDPSCs were collected, isolated, characterized then divided into six groups:groups 1, control; groups 2, biodentine (BD); group 3, irradiation at 1 J/cm2 810-nm diode laser; 4,irradiation culture with BD; 5, 2 J/cm2, 6, J/cm2and BD. Viability assay was measured through MTT...

Introduction: Through scientific literature, Polycystic ovary syndrome (PCOS) is a relatively common endocrine disorder among young women and leads to metabolic problems associated with the onset of infertility. Selenium nanoparticles (SeNps) an essential trace element playing vital role in physiological processes. It was ignored as therapeutic agent past, but recently it revealed that must be obtained from diet cannot produced by organisms.Aim study: The present study might draw attention...

Acrylamide (ACR), a common industrial chemical, is strong neurotoxic material. The hippocampus brain area of interest mostly affected by Alzheimer's disease. Mesenchymal stem cells (MSCs) usefulness in various neurological diseases including being debated. In this work, the authors aim to explore role MSCs ACR-induced hippocampal neurodegeneration and elucidate mediating mechanism.

Abstract Traumatic brain injury (TBI) is a common cause of morbidity and death in all age groups, with an estimated 50 million people having due to trauma each year. Accurate blood-based biomarkers are needed assist diagnosis patients across the spectrum time severity. Our objectives were explore diagnostic precision time- severity- related four biomarkers: AKT3, GSK-3β, hsa-miR-16-5p, MALAT-1 for TBI purpose diagnosis, prognosis, follow-up. 40 samples recruited as following: 30 10 healthy...

Photobiomodulation (PBM) is beneficial to biological tissues; depending on the optical dose that absorbed by tissues, it can function as a biostimulative, analgesic, and anti-inflammatory mediator. Thus, current research aimed assess impacts of PBM Calcium aluminosilicate-based material direct pulp capping (DPC) dogs' permanent teeth through histological analysis.