A5050457145- Circadian rhythm and melatonin
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Long-Term Effects of COVID-19
- Tryptophan and brain disorders
- Nuclear Receptors and Signaling
- COVID-19 Clinical Research Studies
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- Epilepsy research and treatment
- Cardiovascular Health and Disease Prevention
- Histone Deacetylase Inhibitors Research
- Birth, Development, and Health
- Advanced Malware Detection Techniques
- Cardiovascular Disease and Adiposity
- COVID-19 and Mental Health
- Eating Disorders and Behaviors
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Epigenetics and DNA Methylation
- Artificial Intelligence in Healthcare and Education
- Parkinson's Disease Mechanisms and Treatments
- Ion channel regulation and function
Cairo University
2015-2025
The presumed implication of thromboembolic and oxidative stress pathways in parkinsonism guided the current research toward exploration anticoagulant dabigatran etexilate (DE) as a thrombin inhibitor cobalt chloride (CoCl2)-induced (CIP) model, model significance to industrial toxins-related health issues. Oral CoCl2 (12.5 mg/kg) was administered daily for 60 days, with introduction benztropine mesylate (BM) (10 and/or DE (3 on day 31. Rearing, postural instability, pasta handling were...
Haloperidol decanoate (HD) was implicated in cognitive impairment. Agomelatine (AGO) claimed to improve cognition. We aimed at investigating the effects of HD + low- or high- dose AGO on cognition, verifying melatonergic/dopaminergic-to-the cholinergic hypothesis cognition and exploring relevant cardiovascular issues adult male <i>Wistar</i> albino rats. prolonged step through latency <i>by +61.47% (</i><i>ρ < </i><i>0.0001),</i> increased time spent bright light +439.49%...
Abstract Rationale Evidence of the effects chronic caffeine (CAFF)-containing beverages, alone or in combination with agomelatine (AGO) quetiapine (QUET), on electroencephalography (EEG), which is relevant to cognition, epileptogenesis, and ovarian function, remains lacking. Estrogenic, adenosinergic, melatonergic signaling possibly linked dynamics these substances. Objectives The brain CAFF were compared those AGO + QUET CAFF. implications estrogenic, brain-ovarian crosstalk investigated....
Sine the emergence of AI, extensive discussions were adopted on its clinical applications, including diagnosis and management many disorders, dementia, among others. As a progressively cognitive dysfunction, mainly prevalent in older people, AI has been proposed as possible tool that help resolve issues related to early diagnosis, prevention, prognosis dementia. With rising hope, few concerns are underway, both briefly mentioned herein.
Coronavirus disease 2019 (COVID-19) due to the acute respiratory syndrome coronavirus- 2 (SARS-CoV-2) caused a global health crisis that called for re-purposing of many medications. Both implication diabetes mellitus (DM) in increasing risk COVID-19-associated complications, together with claims about involvement acidic pH exacerbating lung injury as well SARS-CoV-2 invasion, growth, and replication, guided our interest towards possible efficacy antidiabetic anti-peptic ulcer medications...
BackgroundIt is estimated that ~10% of the population suffers a single convulsive episode during their lifetime. Epilepsy second most common chronic neurological disorder after stroke, affecting ~0.5% in developed countries and 1.5-2% developing countries. Diazepam (DZ) among benzodiazepines used widely status epilepticus as well resistant refractory seizures. However, tolerance to its antiseizure activity obstacles facing it use on wider basis. Exploration role cyclic nucleotides seizures...
The aim of this study was to assess the effect two types stressors, regarding extent involvement ouabain (OUA), hippocampal sodium/potassium ATPase (NKA) expression, and corticosterone receptors (CR)/melatonin (MR) expression ratio, on behavioral cardiovascular responses cornu ammonis zone 3 (CA3) dentate gyrus (DG). Thirty adult male Wistar albino rats aged 7-8 months were exposed either chronic immobilization or a disturbed dark/light cycle treated with vehicle. In immobilized group, in...