A5007768036- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Nigella sativa pharmacological applications
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Bioactive Compounds and Antitumor Agents
- Hepatitis C virus research
- Advances in Cucurbitaceae Research
- Potato Plant Research
- interferon and immune responses
- Natural Compound Pharmacology Studies
- Bee Products Chemical Analysis
- Silymarin and Mushroom Poisoning
- Angiogenesis and VEGF in Cancer
- Curcumin's Biomedical Applications
- Tannin, Tannase and Anticancer Activities
- Traumatic Brain Injury Research
- Pancreatic function and diabetes
- Flavonoids in Medical Research
- Cytokine Signaling Pathways and Interactions
- Advanced biosensing and bioanalysis techniques
- Virus-based gene therapy research
- Genomics, phytochemicals, and oxidative stress
Ahram Canadian University
2015-2019
Accumulating evidence has shown an abnormal expression of several non-coding RNAs in ovarian tissues which might be closely linked with the pathogenesis PCOS. The aim this study was to identify competing endogenous (ce) RNA network: long (lncRNA), microRNA (miRNA) and their target genes: androgen receptor (AR), follistatin (FST) insulin substrate-2 (IRS-2), are relevant PCOS, underline molecular PCOS assist early diagnosis treatment. Bioinformatic analysis performed retrieve a ceRNA [lncRNA...
Abstract Tamoxifen (TAM) is one of the most successful treatments for breast cancer; however, TAM resistance continues to be a significant barrier. has been reported associated with increased expression human telomerase reverse transcriptase (hTERT). This enzyme shares structural similarity RNA-dependent RNA polymerase (RdRp) viruses, suggesting that RdRp inhibitors may also inhibit hTERT. Favipiravir (FAV) an antiviral drug inhibits viruses. Thus, we propose FAV elicit antitumor effect by...
Reusing food waste is becoming popular in pharmaceutical industries. Watermelon (Citrullus lanatus) rind commonly discarded as a major solid waste. Here, the vitro cytotoxic potential of watermelon extracts was screened against panel human cancer cell lines. Cell cycle analysis used to determine induction death, whereas annexin V-FITC binding, caspase-3, BAX, and BCL-2 mRNA expression levels were degree apoptosis. VEGF-promoting angiogenesis migration also evaluated. Moreover, identification...
Hepatocellular carcinoma (HCC) is characterized by its high vascularity and metastasis. Thymoquinone (TQ), the main bio-active constituent of Nigella sativa, has shown anticancer hepatoprotective effects. TQ's effect mediated through miRNA regulation. miR-1-3p plays a significant role in various cancers but HCC invasiveness remains poorly understood. Bio-informatics analysis predicted that 3'-UTR TIMP3 target for miR-1-3p; Rats were equally divided into four groups: Group 1, negative...
Tamoxifen (TAM) is a key player in estrogen receptor-positive (ER+) breast cancer (BC); however, ∼30% of patients experience relapse and lower survival rate due to TAM resistance. resistance was related the over expression SOX-2 gene, which regulated by E2F3 transcription factor Wnt signaling pathway. It suggested that overexpression suppressed dexamethasone (DEX), glucocorticoid commonly prescribed BC patients. The aim present study explore effect combining DEX on inhibition TAM-resistant...
Diethylnitrosamine (DEN), a hepatocarcinogen, is found in variety of smoked and fried foods was reported to be hepatotoxic mice. Butylated hydroxytoluene (BHT) potent antioxidant used cosmetic formulations as food additive preservative. As result, BHT studied potential inhibitor the early stages diethylnitrosamine (DEN)-induced HCC. Male Wistar albino rats (n = 24) were equally subdivided. Group 1 negative control; 2 3 administered DEN, respectively; 4 received followed by DEN. Blood samples...
Abstract Hepatocellular carcinoma (HCC) is a major health concern in Egypt owing to the high prevalence of hepatitis C virus (HCV) infection. HCC incidence characterized by obvious male predominance, yet molecular mechanisms behind this gender bias are still unidentified. Functional variations X-linked genes have more impact on males than females. Glypican-3 (GPC3) gene, located Xq26 region, has lately emerged as being potentially implicated hepatocellular carcinogenesis. The current study...
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death globally. Chemoprevention most effective technique for reducing HCC incidence. Thymoquinone (TQ), main bioactive constituent Nigella sativa, exhibits anti-inflammatory and antineoplastic activities against various cancers. Therefore, TQ was tested as an inhibitor initial phase diethylnitrosamine (DEN)-induced in rats. Twenty-four male Wistar albino rats were randomly placed into four equal groups. Group 1...
Telomerase enzyme prevents telomere shortening during division, having human telomerase reverse transcriptase (hTERT) as its catalytic subunit. Favipiravir (FAV), an RNA-dependent RNA polymerases inhibitor, shared structural similarity with hTERT and thus assumed to have cytotoxic effect on cancer cells, in addition prophylactic immunocompromised patients. Nanoemulsion (NE) is a potential tumor cells targeting delivery system, thereby enhancing therapeutic efficacy at the intended site,...
Diabetic Kidney Disease (DKD) is a significant challenge in healthcare. However, there are currently no reliable biomarkers for renal impairment diagnosis, prognosis, or staging DKD patients. CircRNAs and microRNAs have emerged as noninvasive efficient biomarkers.We explored Cannabinoid receptor 1 (CNR1), C reactive protein (CRP), hsa_circ_ 0000146 0000072, hsa-miR-21 495 diagnostic DKD. The serum concentrations of CRP CNR1 were measured using ELISA. Rt-qPCR was used to evaluate the...
Baicalin (BG), a natural product, has been used in the prevention and treatment of drug-induced liver injury (DILI); however, its poor solubility extensive metabolism limit pharmacological use. The aim present study was formulation fast-dissolving freeze-dried sublingual tablets (FFSTs) to increase BG dissolution, avoid first-pass metabolism, overcome swallowing difficulties. FFSTs were prepared following 23 factorial design. effect three independent variables namely matrix former,...
Abstract Introduction: Systemic lupus erythematosus (SLE) is a diverse autoimmune disease that arises from combination of complex genetic factors and environmental influences. While circRNAs miRNAs have recently been identified as promising biomarkers for diagnosis, their specific expression patterns, clinical implications in SLE are not yet fully understood. Aim the work: The aim present study was to determine role panel noncoding-RNAs specifically (circ-TubD1, circ-CDC27, circ-Med14),...
Abstract Traumatic brain injury (TBI) is a common cause of morbidity and death in all age groups, with an estimated 50 million people having due to trauma each year. Accurate blood-based biomarkers are needed assist diagnosis patients across the spectrum time severity. Our objectives were explore diagnostic precision time- severity- related four biomarkers: AKT3, GSK-3β, hsa-miR-16-5p, MALAT-1 for TBI purpose diagnosis, prognosis, follow-up. 40 samples recruited as following: 30 10 healthy...
Ribonucleic acids (RNAs) are important regulators of gene expression and crucial for the progression hepatocellular carcinoma (HCC). This study was designed to determine diagnostic prognostic utility circulating long miscellaneous RNAs; LINC01419, AK021443, AF070632 in HCV-related HCC patients. Real-time PCR used measure their relative levels plasma 194 HCV patients, 120 patients healthy controls. LINC01419 AK021443 had significantly increasing linear trend estimates while dramatically...
Hepatocellular carcinoma (HCC) is a universal health problem that particularly alarming in Egypt. The major risk factor for HCC hepatitis C virus (HCV) infection which main burden epithelial cell adhesion molecule (EpCAM) stem marker involved the tumorigenesis and progression of many malignancies, including HCC. We investigated association -935 C/G single nucleotide polymorphism EpCAM promoter region (rs62139665) with risk, expression overall survival Egyptians. A total 266 patients (128 HCV...