A5038413791- Ginger and Zingiberaceae research
- Pharmacological Effects of Medicinal Plants
- Natural product bioactivities and synthesis
- Biological Stains and Phytochemicals
- Drug-Induced Hepatotoxicity and Protection
- Plant-Derived Bioactive Compounds
- Phytochemicals and Antioxidant Activities
- Phytochemistry and Biological Activities
- Curcumin's Biomedical Applications
- Natural Antidiabetic Agents Studies
- Phytochemical compounds biological activities
- Bee Products Chemical Analysis
- Mangiferin and Mango Extracts
- Genetic Neurodegenerative Diseases
- Pharmacological Effects of Natural Compounds
- Advances in Cucurbitaceae Research
- Bioactive Natural Diterpenoids Research
- Natural Products and Biological Research
- Moringa oleifera research and applications
- Phytochemical and Pharmacological Studies
- Phytochemicals and Medicinal Plants
- Psidium guajava Extracts and Applications
- Ginkgo biloba and Cashew Applications
- Natural Compound Pharmacology Studies
- Biological Activity of Diterpenoids and Biflavonoids
October 6 University
2015-2025
Pharmac
2017
Onion peels are often discarded, representing an unlimited amount of food by-products; however, they a valuable source bioactive phenolics. Thus, we utilized UPLC-MS/MS to analyze the metabolomic profiles red (RO) and yellow (YO) onion peel extracts. The cytotoxic (SRB assay), anti-inflammatory (Griess antimicrobial (sensitivity test, MIC, antibiofilm, SP-SDS tests) properties were assessed in vitro. Additionally, histological analysis, immunohistochemistry, ELISA tests conducted investigate...
Berberine (BBR) is a known alkaloid that has verified its protective effects against ischemia/reperfusion (I/RN) lesion in multiple organs but poor oral bioavailability limited use. Despite the previous works, possible impact on warm hepatic I/RN-induced not clear. Accordingly, nanostructured lipid carrier of BBR (NLC BBR) was developed for enhancing efficiency and to inspect mechanistic I/RN.NLC formula evaluated pharmaceutically. Wistar rats were orally pre-treated with either or NLC (100...
This study examined the antidiarrheal activity of lipoid matter Syzygium australe leaves. The effects were assessed through castor oil-induced diarrhea model. Additionally, we investigated acute toxicity S.australe hexane extract. Hexane extract demonstrated a dose-dependent and statistically significant protective effect on rats against diarrhea. It also suppressed intestinal transit postponed gastric emptying in comparison to control group. Regarding toxicity, findings suggested that crude...
Curcumin is a dietary compound with accrued evidence of antiviral activity. Poor solubility and permeation renders curcumin good applicant for incorporation into proniosomes. The intent this study was to formulate proniosomal gel topical application the evaluation its in-vitro, ex-vivo activities against Herpes Simplex virus type 1 (HSV-1), as well molecular docking studies on HSV-1 thymidine kinase proteins. Coacervation phase separation tactic, using 23 full factorial design, used in...
Reusing food waste is becoming popular in pharmaceutical industries. Watermelon (Citrullus lanatus) rind commonly discarded as a major solid waste. Here, the vitro cytotoxic potential of watermelon extracts was screened against panel human cancer cell lines. Cell cycle analysis used to determine induction death, whereas annexin V-FITC binding, caspase-3, BAX, and BCL-2 mRNA expression levels were degree apoptosis. VEGF-promoting angiogenesis migration also evaluated. Moreover, identification...
Abstract Traditionally, Bidens pilosa L. is an edible herb utilized for various ailments. The study accomplished a complete analysis of B. extract including UPLC/T-TOF–MS/MS, GC–MS, and in vitro antiproliferative activity, addition to molecular docking on kinase aldose reductase enzymes. From GC–MS analysis, the percentage identified unsaturated fatty acids (FAs) (11.38%) was greater than saturated FAs (8.69%), while sterols percent (39.92%) higher hydrocarbons (6.6%). Oleic palmitic are...
Morin (MRN), a known natural flavonol, has demonstrated its shielding aptitude against ischemia/reperfusion (I/Re) lesion in various organs. Nonetheless, potential influence on hepatic I/Re-induced injury modulation not been fully elucidated. Consequently, the current study strived to investigate mechanistic maneuvering of MRN I/Re. Furthermore, effects Nrf2, TLR4, and NLRP3 proteins were evaluated via molecular docking studies.
Saussurea costus is a plant traditionally used for the treatment of several ailments. Our study accomplished UPLC/T-TOF-MS/MS analysis methanol extract roots (MESC), in addition to lipoidal matter determination and assessment its vivo hepatoprotective activity. In this study, we were able identify major metabolites MESC rather than previously known isolated compounds, improving our knowledge chemical constituents. The flavones apigenin, acacetin, baicalein, luteolin, diosmetin, flavonol...
Green synthesis of silver nanoparticles using Caesalpinia gilliesii (Hook) leaves extract (70% MeOH) for the first time as a reducing agent were investigated their antimicrobial and cytotoxic activity (using MTT assay).After exposing oxidizing ions to C. extract, rapid reduction in solution is observed due construction nanoparticles.The prepared elucidated by UV-visible spectroscopy, Fourier Transforms infrared spectroscopy (FT-IR) transmission electron microscope (TEM).The purified...
Mangiferin (Mang) is a known glucosylxanthone that has proven its shielding effect against ischemia/reperfusion (Is/R). However, full underlying mechanistic perspective renal Is/R induced lesions not fully revealed. Consequently, the purpose of this study to track further non-investigated modulatory signals Mang model involving nuclear factor erythroid 2-related (Nrf)2/heme oxygenase (HO)-1, peroxisome proliferator-activated receptor (PPAR)-γ/nuclear (NF)-κB, p38 mitogen-activated protein...
Background: Caesalpinia gilliesii Hook is an ornamental shrub with showy yellow flowers. It was used in folk medicine due to its contents of different classes secondary metabolites. In our previous study, dichloromethane extract C. flowers showed a good antioxidant activity. Aim the Study: Isolation and identification bioactive hepatoprotective compounds from fraction. Materials Methods: The activity fraction isolated were studied CCl4-intoxicated rat liver slices by measuring injury markers...
A hitherto unknown polyoxygenated flavonol robinobioside (gossypetin-3-O-β-d-robinobioside) was isolated from the leaves of Caesalpinia gilliesii along with thirteen known phenolic secondary metabolites. The compounds were characterized using spectroscopic analysis, including 1D and 2D NMR mass spectrometry (MS) analyses. extract reduced level liver damage in CCl₄-induced injury rats. decrease biomarkers-aspartate aminotransferase (AST) alanine (ALT) an increase total antioxidant capacity...
The waste products of the tamarind canning industry have been discarded; however, it has potential health benefits. Herein, study was carried out HPLC profiling phenolic constituents Tamarindis indica pericarp and seeds. Furthermore, cytotoxic activity against HUH-7 cells evaluated assessed with molecular docking on angiogenesis-related VEGF kinase proteins in addition to evaluating level released treated by ELISA.Folin-ciocalteu AlCl3 assays were used for quantification total phenolics...