A5104472773- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Acute Kidney Injury Research
- Hepatitis C virus research
- Sepsis Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Lymphoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Drug-Induced Hepatotoxicity and Protection
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Food Allergy and Anaphylaxis Research
- Circular RNAs in diseases
- Respiratory and Cough-Related Research
- Iron Metabolism and Disorders
- Magnesium Oxide Properties and Applications
- Blood properties and coagulation
- Magnesium Alloys: Properties and Applications
- Cytomegalovirus and herpesvirus research
- Infant Health and Development
- Neonatal Health and Biochemistry
- Electrolyte and hormonal disorders
Menoufia University
2019-2025
Pediatrics and Genetics
2022
Liver Institute Northwest
2021
Virus-related hepatocellular carcinoma (HCC) pathogenesis involves liver inflammation, therefore, despite successful treatment, hepatitis C virus (HCV) may progress to HCC from initiated cirrhosis. Cytotoxic T cells (Tcs) are known be involved in HCV-related cirrhotic complications and pathogenesis. The inhibitory checkpoint leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is expressed on Tcs. Therefore, we aimed determine whether the Tc expression level of LAIR-1 associated with...
This study investigated the diagnostic, prognostic, and therapeutic significance of Fc receptor-like 1 (FCRL1) B-cell activating factor (BAFF) mRNA expression in Egyptian patients with diffuse large lymphoma (DLBCL) undergoing standard R-CHOP regimen (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) using quantitative real-time PCR (RT-qPCR). The results demonstrated that FCRL1 BAFF were significantly elevated DLBCL compared to healthy controls. A strong positive...
P-selectin (CD62P) is a platelet activation marker that was claimed to mediate the accumulation of platelets induced by cholestasis. The nature dysfunction and hemostasis abnormalities in cholestatic liver disease needs be more explored. aim this study assess CD62P expression cirrhotic patients with without cholestasis, evaluate its relationship bleeding tendency.150 were included case-control study. Participants divided into 84 cirrhosis (group I), 44 whom had cholestasis (Group Ia) 40 Ib);...
Sepsis Associated Kidney Injury represents a major health concern as it is frequently associated with increased risk of mortality and morbidity. We aimed to evaluate the potential value TNF-α (-376 G/A) cystatin C in diagnosis S-AKI prediction critically ill patients. This study included 200 patients healthy controls. Patients were categorized into 116 acute septic shock 84 sepsis, from which 142 (71%) developed S-AKI. Genotyping was performed by RT-PCR serum CysC assessed Enzyme Linked...
Immune thrombocytopenia (ITP) appears to be a heterogeneous disease. In some patients, autoimmunity may associated with an inflammatory process, and in other low platelets interfere aspects of the coagulation system. Either predispose thrombosis or bleeding. Further investigation interactions platelets, cytokines endothelial biomarkers, help us better understand disease, recognize those patients at risk bleeding, conversely thrombosis. The aim this work is estimate von Willebrand factor...
AFP: alpha-fetoprotein; ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate AURKA: aurora kinase A; BCLC: Barcelona- Clinic Liver Cancer; CBC: complete blood count; CT: computed tomography; DM: diabetes mellitus; DNA: deoxyribonucleic acid; EDTA: ethylene diamine tetraacetic GGT: gamma-glutamyl transferase; HB: hemoglobin; HBV: hepatitis B virus; HBsAg: surface antigen; HCC: hepatocellular carcinoma; HCV: C INR: international normalized ratio; mRNA: messenger ribonucleic...
Background: Portal vein thrombosis (PVT) might be a catastrophic event complicating liver cirrhosis and hepatocellular carcinoma (HCC). Aim: role of JAK2 RS V617F mutation as risk factor for PVT development in HCC. Methods: A case control study conducted on 100 patients (76 HCC 24 cirrhosis) additionally, healthy individuals used group. was diagnosed incidentally by Doppler ultrasound during routine follow-up screening. Prothrombin G20210A mutation, MTHFR Factor V Leiden (VFL), antithrombin...
Abstract Background Cow’s Milk Allergy (CMA) diagnosis is often a challenge due to the non-specific nature of symptoms and lack confirmatory diagnostic test. To our knowledge no previous studies investigated serum Eosinophil-Derived Neurotoxin (sEDN) in CMA. So, we aimed assess role sEDN CMA diagnosis. Methods Forty-five infants with were compared 45 functional gastrointestinal disorders (FGIDs) healthy controls. For all participants, Milk-related Symptom Score (CoMiSS) was documented, level...
Introduction: Hepatorenal syndrome (HRS) is a severe form of functional kidney failure that occurs in advanced liver cirrhosis and associated with poor prognosis. Early recognition management are crucial for improving outcomes. This study aimed to evaluate the prevalence, clinical characteristics, short-term outcomes HRS patients chronic disease. Methods: retrospective included 270 acute injury who were hospitalized between January 2018 December 2019. Patients meeting diagnostic criteria...
Ribonucleic acids (RNAs) are important regulators of gene expression and crucial for the progression hepatocellular carcinoma (HCC). This study was designed to determine diagnostic prognostic utility circulating long miscellaneous RNAs; LINC01419, AK021443, AF070632 in HCV-related HCC patients. Real-time PCR used measure their relative levels plasma 194 HCV patients, 120 patients healthy controls. LINC01419 AK021443 had significantly increasing linear trend estimates while dramatically...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA El-Mashad GM, El-Hawy MA, NaserBahbah HM, Bedair Habib MI. The effect of L-carnitine therapy on anaemia in paediatric patients regular haemodialysis. Pediatria Polska - Polish Journal Paediatrics. 2021;96(4):238-244. doi:10.5114/polp.2021.112397. APA El-Mashad, G. M., El-Hawy, M. A., NaserBahbah, H. Bedair, & Habib, I. (2021). Paediatrics, 96(4), 238-244. https://doi.org/10.5114/polp.2021.112397 Chicago Ghada...
Background: Most patients with hepatocellular carcinoma (HCC) are diagnosed at late stages despite of improvement screening programs and lack effective diagnostic methods for cases preclinical HCC leads to a low rate early detection. Aldo-keto reductase family 1 member B10 (AKR1B10) is associated several types cancer. However, our knowledge, the significance AKR1B10 measurement in stage has poorly understood.
 Aim
 To evaluate performance serum hepatitis C virus (HCV)-related liver...
Neopterin, a guanosine triphosphate metabolite, is an indicator for cell-mediated immunity. Kynurenine performs variety of biological functions, such as the dilation blood vessels in response to inflammation and regulation immune response. Objectives: assess serum neopterin kynurenine levels Egyptian children with sickle cell disease (SCD). In our case-control study, we included 40 aged 2–18 years SCD treated at Hematology Unit Department Pediatrics, Menoufia University Hospital healthy...
Chronic hepatitis C (CHC) is a leading cause of cirrhosis and hepatocellular carcinoma (HCC). This study aimed to the association IL28B, toll-like receptor (TLR) 7, cytomegalovirus advanced liver disease.Four groups were included; control (n = 125, 25.9%), CHC 114, 23.6%), 120, 24.8%), HCC 124, 25.7%).In group, patients mainly F1 (60%) followed by F2. IL28B genotype CC percentage was higher in group than groups. CT TT genotypes group. The allele CHC, opposite with T allele. Control had same...
Background: Severe thrombocytopenia and platelet dysfunctions are common amongst patients with cirrhosis can contribute to increase risk of bleeding in patient portal hypertension (PH).Many studies confirmed the close association between accordance variceal bleeding.But relationship function disorder is still a matter debate.Objectives: This study aimed evaluate effect count, platelets indices functions cirrhotic different grade oesophageal varices (OV) identifying potential factors...
Objectives: To evaluate the integration of clinical, morphological, cytogenetic features and MPL gene mutation analysis in Egyptian patients with clonal thrombocytosis correlate these finding to patient’s outcome. Background: Thrombocytosis can be caused by either reactive or autonomous processes as a result genetic alterations that affect signaling pathway through gain-of-function activity (myeloproliferative leukemia virus), Janus kinase 2 (JAK 2), calreticulin (CALR). Methods: This study...
Abstract Background : Hepatocellular carcinoma (HCC) is a multifactorial disease needs widened genetic studies. Taking in consideration the probable role of new direct-acting antiviral therapies (DAAs) Hepatitis C infection (HCV) as predisposing factor HCC it provides longer lifetime for many late cirrhotic patients to develop hepatocellular carcinoma. Considering reported potential biological roles ADAM 10 inflammation and carcinogenesis. These intrigued idea study investigate rs.653765 SNP...
Background: C-MYC, BCL2 and BCL6 genes are the most commonly involved oncogenes detected in B-non-Hodgkin's lymphomas (B-NHLs).Histopathology is best method used to diagnose B-NHLs.However, cytological analysis of bone marrow smears imprints could provide a chance for precise diagnosis these disorders.Objective: This study aimed evaluate findings as an integral part staging workup B-NHLs possible relationship BCL-2, BCL-6 gene abnormalities.Patients methods: was conducted cross-sectional...