The diagnostic criteria for Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) and Associated Steatotic (MASLD) aim to refine the classification of fatty liver diseases previously grouped under Non-Alcoholic (NAFLD). This study evaluates applicability MAFLD MASLD frameworks in NAFLD patients, exploring their clinical utility identifying high-risk patients. A total 369 patients were assessed using criteria. Baseline characteristics, metabolic profiles, hepatic fibrosis,...

Nonalcoholic fatty liver disease (NAFLD) is a spectrum of disorders ranging from simple hepatic steatosis up to nonalcoholic steatohepatitis (NASH) evolving cirrhosis and hepatocellular carcinoma (HCC). Liver biopsy still the gold standard modality for diagnosing staging NAFLD. The linkage between intestinal microbiota NAFLD, might suggest potential role serum zonulin in NAFLD diagnosis. To appraise circulating pathogenesis, 56 subjects with proved by ultrasonography biopsy, as well 20...

Abstract Background Hepatocellular carcinoma (HCC) is the seventh most common cancer in world and a form of liver that starts cells liver. The best way to increase chances survival for people at high risk HCC detect it early through regular monitoring. For monitoring purposes, recommended conduct ultrasound exams every 4 6 months, sometimes combination with alpha-fetoprotein tests. Aim work Assess surveillance its ability patients on improve their management. Patients methods study involved...

Despite the ample flow of non-alcoholic fatty liver disease (NAFLD) drugs in pipeline, lifestyle modifications are still optimal solution NAFLD. The aim study was to assess short term effects Ramadan fasting (RF) as a sort intermittent (IF) on biochemical, radiological, and anthropometric parameters NAFLD patients.Ninety-eight patients were recruited voluntarily subjected 16 hours daily for an average 22-29 days, without special dietary recommendations. Anthropometric, laboratory...

Objective: hepatocellular carcinoma (HCC) is a dreadful complication of liver cirrhosis. Aim was to study the effect sarcopenia on survival in patients with HCC. Methods: we included 262 and were followed up for 12 months. Sarcopenia calculated by skeletal muscle index (SMI). defined SMI ≤39 cm2/m2 women ≤50 men. Results: (n= 113, 43.1%) older, mainly males, Child-Pugh class B smokers. Patients had lower than those without (10.09 vs. 11.72 months). Survival also Barcelona clinic cancer stage...

Abstract Drug-induced liver injury (DILI) is a frequent cause of and acute failure. We aimed to review all hospitalized DILI cases in tertiary Egyptian center from January 2015 through 2016. Cases with elevated alanine aminotransferase more than 3-fold and/or alkaline phosphatase 2-fold the upper limit normal value were prospectively recruited followed for one year. Drug history, biopsy whenever feasible application Roussel Uclaf Causality Assessment Method (RUCAM) diagnostic prerequisites...

See the commentary-article "What we know about paracentesis induced circulatory dysfunction?" on page 349.

Background: Liver fibrosis is common consequence of chronic HCV infection. Noninvasive assessment still evolving. Aim: Evaluate role liver stiffness measurement (LSM), spleen (SSM) and their combination (CLSM) using FibroScanTM in CHC patients. Methods: 420 patients 40 healthy controls included.Liver, renal function tests, CBC INR done. biopsy done for all them except if contraindicated. Fibrosis was graded by Metavir score. Abdominal ultrasonography before the biopsy. LSM, SSM, CLSM had...

Chronic hepatitis B virus (HBV) infection is one of the major health problems worldwide. Use non-invasive tests for assessment hepatic fibrosis such as FIB-4 index could be used to avoid liver biopsy. Another promising noninvasive test, FIB-5, also detect significant fibrosis. The aim study was compare use FIB-5 and markers assess chronic HBV-related fibrosis.This done on 176 HBV patients who underwent Grading staging according METAVIR scoring system. scores were calculated all patients.As...

The albumin bilirubin (ALBI) score and model of end stage liver disease (MELD) are prognostic in patients with hepatocellular carcinoma (HCC). Aim was to compare MELD-sarcopenia MELD ALBI scores HCC awaiting transplantation.patients (n=262) were included followed up for 12 months. Baseline MELD, models calculated.The average age 59.61 ±8.09 years. Most males (69.5%), CTP class A (55.7%) BCLC B (54.2%). Hepatitis C virus the main cause cirrhosis most (88.9%). median 10.65 ±2.54, 15.11 ±6.22...

Abstract Background Metabolic-associated fatty liver disease (MAFLD) has emerged as the predominant form of chronic globally linked with heightened cardiovascular (CVD) risk, leading cause mortality among affected individuals. Aim This study aims to assess serum PTX3 (pentraxin 3) and platelet-derived growth factor receptor beta (PDGFRβ) potential non-invasive biomarkers for predicting risk (CVR) in MAFLD patients. Method A case–control investigation encompassing 84 patients without prior...

Enhancing prognostication in Hepatocellular Carcinoma (HCC) remains an unmet need, especially patients with preserved liver function. This study aimed to integrate the Platelet-to-White Blood Cell Ratio (PWR) albumin-bilirubin (ALBI) and platelets-albumin-bilirubin (PALBI) scores for improved assessment of mortality treatment responses hepatocellular carcinoma patients.

Early diagnosis of ankylosing spondylitis (AS) is yet not elucidated, with a potential diagnostic glance microRNAs (miRNAs).Study the expression profile miRNA-451a and miRNA-125a in AS patients their impact on disease activity prognosis.A cross-sectional study included 55 diagnosed according to modified New York criteria 1984 matched healthy controls. History, clinical examination, assessment Bath index (BASDAI) were done. Full laboratory radiological along m iRNA-451a tabulated...

P-selectin (CD62P) is a platelet activation marker that was claimed to mediate the accumulation of platelets induced by cholestasis. The nature dysfunction and hemostasis abnormalities in cholestatic liver disease needs be more explored. aim this study assess CD62P expression cirrhotic patients with without cholestasis, evaluate its relationship bleeding tendency.150 were included case-control study. Participants divided into 84 cirrhosis (group I), 44 whom had cholestasis (Group Ia) 40 Ib);...

Abstract Background Being infrequent, drug-induced acute pancreatitis (DIP) is an overlooked clinical entity that can be serious with significant morbidity and mortality. Main body A renovative review of drugs incriminated in had been presented all relevant data case presentations. Antibiotics, antidiabetics, antihypertensive agents, H2 blockers (H2B) proton pump inhibitors (PPIs), anticancer therapies, the new direct-acting antiviral therapies (DAAs) hepatitis C virus (HCV) were discussed...

Introduction: There is a growing need for identification of non-endoscopic, non-invasive methods that can accurately predict esophageal varices (EV). Previous studies found an inconclusive correlation between blood ammonia level and the presence size EV. Aim: We aimed at assessing value serum as method early prediction Patient methods: The study included 204 patients with HCV-related cirrhosis. selected were categorized into two groups: EV those without, also no or small large group. All...

Nonalcoholic fatty liver disease (NAFLD) is a spectrum of disorders ranging from simple fat accumulation in the hepatocytes (hepatic steatosis), to inflammation and injury (nonalcoholic steatohepatitis, NASH) with increasing levels fibrosis cirrhosis hepatocellular carcinoma (HCC). So, current study aimed determine role circulating zonulin NAFLD correlate its level biochemical parameters, IL-6 histopathology. The included 56 adults subjects proved by ultrasonography biopsy, as well 20...

Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination early diagnosis of hepatoma, complications their preventions treatments, etc.

Abstract Background The rapidly developing era of direct-acting antiviral regimens (DAAs) for more than one hepatitis C virus (HCV) genotype had certainly alleviated HCV burden all over the world. Liver fibrosis is major dramatic complication infection, and its progression leads to cirrhosis, liver failure, hepatocellular carcinoma. impact DAAs on been debatably evaluated with undetermined resolution. Main body aim this review accurately revise effects DAA which can either be regression,...

The primary goal of HCV therapy is to achieve a sustained virological response (SVR). Many host and viral factors influence the treatment response. Cytokines play an important role in defense against infections, where successful hepatitis C depends on complex balance between pro‐ anti‐inflammatory responses. In present study, we investigated relationship presence percentage some cytokines (IL‐28, IFN‐γ, TNF‐α) regarding different clinicopathological parameters including chronic patients...

Objective . Liver transplantation (LT) is the recommended treatment for patients with advanced liver disease and cirrhosis in all guidelines, mostly as a complication of HCV. The distinction between reinfection graft HCV acute cellular rejection (ACR) essential because they are managed differently. Hepatic macrophages, which can either arise from circulating blood-derived monocytes (BDM) or resident tissue Kupffer cells, central pathogenesis chronic injury. aim this work was to evaluate...

Background The efficacy of adding ribavirin (RBV) to direct antivirals (DAAs) in HCV treatment is still debatable, with allegations insecure profiles.Objectives To evaluate safety and RBV the era DAAs chronic Egyptian patients.Methods In this cohort retrospective study, data 847 patients treated different regimens or without were recruited between June 2017 September 2018. Cases categorized into five groups: non-cirrhotic (318), compensated (196), decompensated liver cirrhosis (53), post...