Interleukin IL-17A and IL-17F are critical cytokines involved in inflammatory processes. Genetic variations might be linked to chronic hepatitis C (CHC) an increased risk of hepatocellular carcinoma (HCC), a cancer associated with long-term inflammation. This study aims examine the relationship between specific polymorphisms (rs2275913) (rs763780) their association HCV-related HCC Egyptian population. Authors conducted case-control involving 52 patients C, 49 HCC, 51 healthy controls. The...

Background: Colorectal cancer (CRC) is considered as the most common type of gastrointestinal cancers. Chemotherapy became limited due to adverse side effects. Therefore, effective Croton tiglium extract was selected be incorporated by silver nanoparticles (Ag-NPs) then evaluated against colon induced azoxymethane (AOM) in rats. Methods: Different hematological and biochemical measurements were quantified addition markers oxidative stress. Specific tumor inflammatory assayed. Colonic tissues...

Hepatocellular carcinoma is a major health problem worldwide especially in Egypt. It accounts for the fifth common cancer and second cause of death among different cancers. This study investigated efficacy molecular mechanism Nisin and/or Thioridazine as anticancer treatment on human liver HepG2 cell line.Nisin were applied 24 h line (HepG2). 3-(4, 5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was done to assess cytotoxicity Thioridazine. Quantitative reverse...

Diabetes mellitus is a chronic degenerative disease.In the developed countries, it considered as third leading cause of death following heart and cancer diseases.The most effective algal extract was prepared from Nannochloropsis oculata to treat diabetes-induced by Streptozotocin (STZ).In present study, STZ showed significant (P < 0.05) increase in glucose C-reactive protein (CRP) levels associated with decline insulin level.This parallel histopathological alterations pancreas diabetic...

Casuarina equisetifolia bark is rich in various active metabolites and selected to be studied due limitation of the synthetic antioxidants that have adverse side effects. The present study aimed enhance efficiency most effective extract by incorporating gold nanoparticles (Au-NPs).The phytochemical biological measurements were carried out total methanolic its successive fractions. Moreover, these assayed after Au-NPs.The revealed exhibited highest cytotoxic activities as compared other...

Croton tiglium L. seeds were studied against colon cancer induced chemically in rats after incorporating silver nanoparticles (Ag-NPs) but the body has no ability to discrete or ions. Therefore, present study was designed reveal biological activities of different C. extracts incorporated with zinc oxide (ZnO-NPs).It found that provided high contents total protein (27.43 g/100g), carbohydrate (18.29 g/100 g) and lipid (46.31 g). The chromatographic techniques revealed concentrations...

In Egypt, Sofosbuvir (SOF) in combination with Dataclasvir (DCV) is the broadly used DAAs excellent therapeutic profile. This study designed to explore relation between IL28B/TLR4 genetic variants and each of followings; HCC development post SOF/DCV treatment, progression naïve patients therapy outcome. A total 493 blood samples were collected (controls (n = 70); HCV treated 252) whom 65 developed HCC, 187 didn't develop (125 responders, 62 relapsers); 171) had early 48), late liver fibrosis...

Background Ashwagandha plant enhances the body’s defense against toxicants through improving cell-mediated immunity. Objective The present work was performed to assess protective and therapeutic efficiencies of ashwagandha seed extract (ASE) harmful effects amoxicillin (AM) treatment on biological physical parameters in brain, liver, testes tissues rats. Materials methods Total RNA isolated from gene expression steroid 5 alpha-reductase 1 (5α-R1), multidrug resistant 1b (mdr1b), luteinizing...

The present work evaluated the effect of flaxseed oil (FO) against toxicity induced by cadmium chloride (CdCl2) in mouse liver and kidney. Male Swiss albino mice were treated with CdCl2 (4.5 mg/kg, intraperitoneally) or without FO at three concentrations (4, 8, 12 mL/kg, orally) for two consecutive weeks. To analyze effects FO, we used following techniques: (1) histopathological examination; (2) comet assay; (3) RT-PCR gene expression analysis tumor necrosis factor (TNF-α) suppressor protein...

Background: Intrauterine adhesions (IUA) remain a major cause of infertility. The prevalence IUA varies geographically and keeps increasing over the last few decades due to increased hysteroscopic surgeries. Therefore, management has received considerable attention. However, IUAs still presents big challenge: recurrence rate could be up 62.5% in severe IUAs. adhesion occurs as result endometrial destruction by surgical interventions or infection causing obliteration uterine cavity which...

Introduction: Globally, Breast cancer (BC) is considered the second most common type of and principal cause death among affected women. Aim: In this study, we targeted to demonstrate association MTHFR single gene polymorphisms (SNPs) with susceptibility breast cancer, in addition its correlation clinical patient features. Patients Methods: This work was conducted on 100 Egyptian females 60 healthy matched controls. Clinical examinations pathological investigations were recorded. Genotyping...

Hepatitis C virus (HCV) infection results in chronic hepatitis more than 70% of infected patients, while 20-30% patients recover spontaneously. This strengthens the role host genetic factors either spontaneous or drug-induced viral clearance. The aim this study was to investigate relationship between interleukin-1β +3953 gene polymorphism and response interferon therapy HCV with genotype 4.The (+3953 C/T) (rs1143634) amplified 115 patients. Interleukin-1β single nucleotide (SNP) plus several...

The bark of Casuarina equisetifolia contains several active phytoconstituents that are suitable for the biosynthesis gold nanoparticles (Au-NPs). These were subsequently evaluated their effectiveness in reducing toxicity induced by Chlorpyrifos (CPF) rats. Various hematological and biochemical measurements conducted this study. In addition, markers oxidative stress inflammatory reactions quantified liver brain tissues evaluated. Histopathological examinations performed on both tissues....

Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic disease cirrhosis. It considered as second leading cause cancer-related death worldwide over 500,000 people affected. Incidence HCC highest Asia Africa, where endemic high prevalence hepatitis B C strongly predisposes to development subsequent HCC. In most cases, cancer long-term damage scarring cirrhosis that may be caused by viral infections (Virus or C)...

Objective: The present work investigated the protective effect of Ficus carica (common fig) leaves methanol extract against genotoxicity and testicular damage cisplatin (CP) identified some its active ingredients. Methods: Seven main groups were as follows: I. control negative, II. Control plant (600 mg/kg fig, orally), III, IV. positive (treated i.p with 10 15 CP), V-VII. treated fig (200, 400 600 mg/ kg) + Cisplatin (15 mg/kg). Results: alleviated destructive effects CP in testis, liver...

Saccharomyces cerevisiae (S. cerevisiae) has been demonstrated in vitro to sensitize several breast cancer cell lines and be a safe, non-toxic drug with anti-skin action mice. Furthermore, plasmonic photothermal treatment using gold nanorods authorized as novel method for vivo therapy.When compared tumor-free rats, the S. conjugated nanospheres (GNSs) lowered Bcl-2 levels while increasing FasL, Bax, cytochrome c, caspases 8, 9, 3 levels. Histopathological results showed changes reflecting...

New series of triazolopyrimidine derivatives were designed, synthesized and fully characterized by spectroscopic tools. The new compounds investigated as antimicrobial agents against two bacterial fungal strains. results revealed that the derivative 3b exhibited excellent antibacterial antifungal activity higher than standard drug (Neomycin). Additionally, we studied antiviral three different viruses (Corona Virus 229E, herpes). fluoro 3a,b showed significant low pathogenic Corona virus...

Lithium (Li) is considered as the first therapeutic line for treatment of bipolar affective disorders and manic-depressive illness. Renal toxicity can be categorized most common undesirable side effect Li therapy. Therefore, present study aimed to reveal efficiency chitosan (CS) a natural chelator against renal induced result injection. During current experiment, functions (urea, creatinine, blood urea nitrogen (BUN), uric acid total protein) were determined in serum samples. The urinary...

Pendimethalin (PND) is a dinitroaniline herbicide widely used to control broadleaf and annual grasses. Although the acute oral toxicity of PND >5 g/kg b.wt. in humans (LD50 for rats >5000 b.wt.), it has been classified as possible human carcinogen. It still agriculture so agricultural workers their families, well consumers, can be exposed this herbicide. The present study first report investigating dose-response effect using benchmark dose (BMD) adverse effects exposure at low via apoptosis...

Osteoarthritis is a substantial burden for patients with the disease. The known medications disease target mitigation of disease's symptoms. So, drug development management osteoarthritis represents an important challenge in medical field. This work based on new benzofuran-pyrazole-pyridine-based compound 8 potential anti-inflammatory and anti-osteoarthritis properties. Microanalytical spectral data confirmed chemical structure 8. biological assays indicated that produces multifunctional...

Background: One of the main causes cancer-related deaths is breast cancer. Fascin-1(FSCN1) an actin-binding protein that present in mesenchymal, neuronal, and endothelial cells mammals. Patients with cancer have been found to FSCN1 overexpression. CD44 crucial for development, invasion, tumour spread. Therefore, we aimed investigate role FSCN1&CD44 gene polymorphisms (BC) risk prognosis. Materials & Methods: A total 96 BC patients 50 controls were included case-control study prediction. We...

A LLIUM vegetables have been recorded to be used in many medical remedies for protection and fighting diseases.The aim of the study is investigate phenolic compounds methanol extract Allium porrum L. aerial parts (MEAP) introduce methanolic as a candidate treatment cancer vivo well explore its antitumor mechanisms attacking tumor cells at molecular level.Isolation flavonoid by column chromatography has carried out.They were purified Sephadex LH-20, structures established with aid...