A5101558509- Chromatin Remodeling and Cancer
- T-cell and B-cell Immunology
- Biopolymer Synthesis and Applications
- Metal complexes synthesis and properties
- Conducting polymers and applications
- Multiple Myeloma Research and Treatments
- RNA Research and Splicing
- Electrochemical sensors and biosensors
- Nonlinear Optical Materials Research
- Cancer Cells and Metastasis
- Pulsars and Gravitational Waves Research
- Hepatitis B Virus Studies
- Quinazolinone synthesis and applications
- Molecular Sensors and Ion Detection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cellular Mechanics and Interactions
- Cancer Mechanisms and Therapy
- Protein Degradation and Inhibitors
- RNA regulation and disease
- Cerebrospinal fluid and hydrocephalus
- Organic Electronics and Photovoltaics
- Intraperitoneal and Appendiceal Malignancies
- vaccines and immunoinformatics approaches
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
National Research Centre
2024
Minia University
2015-2024
Kyoto University
2023-2024
Cairo University
2019-2023
Mahak Hospital and Rehabilitation Complex
2012
Children's Memorial Health Institute
2012
Instituto de Medicina Integral Professor Fernando Figueira
2012
Children Cancer Hospital
2012
B cells generate functionally different classes of antibodies through class-switch recombination (CSR), which requires classical non-homologous end joining (C-NHEJ) to join the DNA breaks at donor and acceptor switch (S) regions. We show that RNA-binding protein HNRNPU promotes C-NHEJ-mediated S-S 53BP1-shieldin DNA-repair complex. Notably, binds S region RNA/DNA G-quadruplexes, contributing regulating R-loop single-stranded (ssDNA) accumulation. is an intrinsically disordered interacts with...
Abstract Efficient repair of DNA double-strand breaks in the Ig heavy chain gene locus is crucial for B-cell antibody class switch recombination (CSR). The regulatory dynamics pathway direct CSR preferentially through nonhomologous end joining (NHEJ) over alternative (AEJ). Here, we demonstrate that histone acetyl reader BRD2 suppresses AEJ and aberrant as well random genomic sequence capture at junctions. deficiency impairs (S) region synapse, optimal damage response (DDR), increases break...
Marburg virus (MARV) is one of the most harmful zoonotic viruses with deadly effects on both humans and nonhuman primates. Because its severe outbreaks a high rate fatality, world health organization put it as risk group 4 pathogen focused urgent need for development effective solutions against that virus. However, up to date, there no vaccine MARV in market. In current study, complete proteome (seven proteins) was analyzed antigenicity score virulence or physiological role each protein...
Metal complexes of the 2,2'-(1,3-phenylenebis(diazene-2,1-diyl))bis(4-aminobenzoic acid) diazo ligand (H2L) derived from m-phenylenediamine and p-aminobenzoic acid were synthesized characterized by different spectral, thermal, analytical tools. The H2L reacted with metal ions Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) as 1 : stoichiometry. All displayed an octahedral geometry according to electronic magnetic moment measurements. IR spectra revealed binding azo via two...
The NRAS gene is a well-known oncogene that acts as major player in carcinogenesis. Mutations the have been linked to multiple types of human tumors. Therefore, identification most deleterious single nucleotide polymorphisms (SNPs) necessary understand key factors tumor pathogenesis and therapy. We aimed retrieve missense SNPs analyze them comprehensively using sequence structure approaches determine could increase risk also adopted structural biology methods docking tools investigate...
Abstract Due to its appealing qualities, such as miniature size and the ability modify physical properties through chemical synthesis molecular design, polymer material offers considerable advantages over traditional inorganic material-based electronics. Conjugate polymers are particularly interesting because of their design capabilities, which enable conducting with a variety ionization potentials electron affinities (EA), control energy gap electronegativity (χ). Accordingly, density...
Background: One of the main causes cancer-related deaths is breast cancer. Fascin-1(FSCN1) an actin-binding protein that present in mesenchymal, neuronal, and endothelial cells mammals. Patients with cancer have been found to FSCN1 overexpression. CD44 crucial for development, invasion, tumour spread. Therefore, we aimed investigate role FSCN1&CD44 gene polymorphisms (BC) risk prognosis. Materials & Methods: A total 96 BC patients 50 controls were included case-control study prediction. We...
Background: Recently, the predictive usefulness of variations in cancer antigen CA15-3 for breast (BC) has received much attention.Objective: This study aimed to assess relationship between kinetics serum level and outcome patients with non-metastatic BC.Patients methods: prospective single center trial was carried out Medical Oncology Department, South Egypt Cancer Institute (SECI), Assiut University, on 75 female BC patients.The evaluated via Roche Elecsys at three time points...
Medulloblastoma (MB) accounts for approximately 20% of pediatric central nervous system neoplasms.Current standard management includes safe maximal surgical resection followed by craniospinal irradiation (CSI) with chemotherapeutic radiosensitization adjuvant chemotherapy.The overall and event free survival rates depend upon many prognostic factors.PURPOSE: To investigate treatment outcome newly diagnosed MB patients treated at the Children's Cancer Hospital Egypt 57357 (CCHE) to determine...
A TOTAL of eight new metal complex derivatives 4,4'-((1Z,1'Z)-(naphthalene-1,8- diylbis(azanylylidene))bis(methanylylidene))dibenzaldehyde, H 2 L with the ions Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) have been successfully prepared in alcoholic medium.The complexes obtained are characterized quantitatively qualitatively by using micro elemental analysis, conductivity measurements, FT-IR spectroscopy, UV-Vis mass 1 HNMR, magnetic susceptibility, thermal (TG/DTG)...
Background and objectives: Multiple myeloma (MM) is a malignant neoplasm of plasma cells accounting for approximately 10% all hematologic cancers.The rates MM vary among different populations findings on racial differences in survival have been inconclusive.Our aim to investigate the demographic data with reviewing lines treatment assess outcome patients treated from at single institution over an 11-year period.Methods: This retrospective study involved 70 who were January 1, 2008 December...