Jacek Wachowiak
A5064396176- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Neutropenia and Cancer Infections
- Lymphoma Diagnosis and Treatment
- Polyomavirus and related diseases
- Antifungal resistance and susceptibility
- Chronic Myeloid Leukemia Treatments
- Multiple and Secondary Primary Cancers
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Neuroblastoma Research and Treatments
- Fungal Infections and Studies
- Antibiotics Pharmacokinetics and Efficacy
- Immune Cell Function and Interaction
- Ethics and Legal Issues in Pediatric Healthcare
- Sarcoma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Geological Formations and Processes Exploration
- Blood disorders and treatments
- Geological and Geochemical Analysis
- Geology and Environmental Impact Studies
Poznan University of Medical Sciences
2016-2025
Centrum Onkologii
1999-2024
AGH University of Krakow
2012-2022
Leiden University Medical Center
2020
University of Luxembourg
2019
Nicolaus Copernicus University
2018
Medical University of Warsaw
2015
Shanghai Jiao Tong University
2012
Greater Poland Cancer Center
1997-2011
Society of Paediatric Oncology and Haematology
2010
The advances in hematopoietic cell transplantation (HCT) over the last decade have led to a transplant-related mortality below 15%. Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is life-threatening complication of HCT that belongs group diseases increasingly identified as transplant-related, systemic endothelial diseases. In most cases, SOS/VOD resolves within weeks; however, severe results multi-organ dysfunction/failure with rate >80%. A timely diagnosis critical...
Abstract Although most children with acute lymphoblastic leukemia (ALL) receive fractionated total body irradiation (FTBI) as myeloablative conditioning (MAC) for allogeneic hematopoietic stem cell transplantation (allo-HSCT), it is an important matter of debate if chemotherapy can effectively replace FTBI. To compare outcomes after FTBI versus chemotherapy-based (CC), we performed a retrospective EBMT registry study. Children aged 2–18 years MAC first allo-HSCT bone marrow (BM) or...
Relapse remains the major cause of treatment failure in children with high-risk acute lymphoblastic leukaemia (ALL) undergoing allogeneic haematopoietic stem-cell transplantation (allo-SCT). Prognosis is considered dismal but data on risk factors and outcome are lacking from prospective studies. We analysed 242 recurrence ALL after first allo-SCT enrolled Berlin-Frankfurt-Munster (BFM) ALL-SCT-BFM 2003 international 2007 Median time to relapse was 7·7 months; median follow-up until last 3·4...
COnstraint-Based Reconstruction and Analysis (COBRA) provides a molecular mechanistic framework for integrative analysis of experimental data quantitative prediction physicochemically biochemically feasible phenotypic states. The COBRA Toolbox is comprehensive software suite interoperable methods. It has found widespread applications in biology, biomedicine, biotechnology because its functions can be flexibly combined to implement tailored protocols any biochemical network. Version 3.0...
Incidence and outcome of microbiologically documented bacterial/viral infections invasive fungal disease (IFD) in children adults after hematopoietic cell transplantation (HCT) were compared 650 3200 multicenter cross-sectional nationwide study. Infections diagnosed 60.8% 35.0% adults, including respectively 69.1% 63.5% allo-HCT, 33.1% 20.8% auto-HCT patients. The incidence bacterial was higher (36.0% vs 27.6%; p < 0.0001). with Gram-negative bacteria more frequent than Gram-positives (64.6%...
Specific protocols define eligibility, conditioning, donor selection, graft composition and prophylaxis of vs. host disease for children young adults undergoing hematopoietic stem cell transplant (HSCT). However, international rarely, if ever, detail supportive care, including pharmaceutical infection prophylaxis, physical protection with face masks cohort isolation or food restrictions. Supportive care suffers from a lack scientific evidence implementation practices in the centers brings...
Despite poor survival, controversies remain in the treatment for refractory or relapsed pediatric non-Hodgkin lymphoma (r/r NHL). The current project aimed to collect international experience on re-induction of r/r NHL, hematopoietic stem cell transplantation (HSCT), risk factors associated with outcome, and suggest recommendations. Inclusion criteria were (i) disease, disease progression relapse any NHL subtype except anaplastic large lymphoma, (ii) age < 18 years at initial diagnosis,...
Post-transplant lymphoproliferative disorder (PTLD) caused by Epstein-Barr virus (EBV) is a severe complication in high-risk allogeneic hematopoietic stem cell transplant (HSCT) recipients. Central nervous system (CNS) involvement of PTLD very rare event patients with HSCT. As no established standard therapy CNS-EBV-PTLD available, the aim this study was analysis safety and efficacy intrathecal rituximab group eight children adolescents CNS-EBV-PTLD. Seven responded to therapy: all clinical...
Background Standard myeloablative conditioning regimens for children with hematological malignancies undergoing allogeneic HSCT are based mainly on total body irradiation or busulfan. Their serious short‐ and long‐term side effects warranted the exploration of less toxic alternatives. Treosulfan is increasingly used adults before due to its potent immunosuppressive cytotoxic combined low organ toxicity. Procedure To further investigate role treosulfan in children, EBMT Pediatric diseases...