Marianne Ifversen
A5075403858- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Chronic Myeloid Leukemia Treatments
- Blood disorders and treatments
- Neonatal Respiratory Health Research
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Reproductive Biology and Fertility
- Parvovirus B19 Infection Studies
- Autoimmune and Inflammatory Disorders Research
- Neutropenia and Cancer Infections
- Renal Transplantation Outcomes and Treatments
- Cytomegalovirus and herpesvirus research
- Adolescent and Pediatric Healthcare
- Sperm and Testicular Function
- Mesenchymal stem cell research
- Lymphoma Diagnosis and Treatment
- Oral health in cancer treatment
- Transplantation: Methods and Outcomes
- Gut microbiota and health
- Salivary Gland Disorders and Functions
Copenhagen University Hospital
2016-2025
Rigshospitalet
2016-2025
University of Copenhagen
2018-2021
Capital Region of Denmark
1998-2017
Total body irradiation (TBI) before allogeneic hematopoietic stem cell transplantation (HSCT) in pediatric patients with acute lymphoblastic leukemia (ALL) is efficacious, but long-term side effects are concerning. We investigated whether preparative combination chemotherapy could replace TBI such patients.FORUM a randomized, controlled, open-label, international, multicenter, phase III, noninferiority study. Patients ≤ 18 years at diagnosis, 4-21 HSCT, complete remission pre-HSCT, and an...
Hemophagocytic lymphohistiocytosis is a hyperinflammatory syndrome defined by clinical and laboratory criteria. Current criteria were created to identify patients with familial hemophagocytic lmyphohistiocytosis in immediate need of immunosuppressive therapy. However, these also infection-associated inflammatory states lacking genetic defects typically predisposing lymphohistiocytosis. These include those primary immunodeficiencies, whom the pathogenesis may be distinctive aggressive...
Thymus transplantation is a promising strategy for the treatment of athymic complete DiGeorge syndrome (cDGS).Twelve patients with cDGS underwent allogeneic cultured thymus.We sought to confirm and extend results previously obtained in single center.Two died pre-existing viral infections without having thymopoiesis, 1 late death occurred from autoimmune thrombocytopenia. One infant had septic shock shortly after transplantation, resulting graft loss need second transplant. Evidence...
Is there an association between the need for medical puberty induction and diagnosis or treatment received in girls who have undergone cryopreservation of ovarian tissue fertility preservation? There was a clear intensity requirement but no with diagnosis. Although it cannot be predicted which will become infertile develop premature insufficiency (POI) following intensive chemotherapy irradiation, patients are at high risk POI should offered (OTC). This includes planned to receive either...
Anti-thymocyte globulin (ATG) is a lymphocyte depleting agent applied in hematopoietic stem cell transplantation (HSCT) to prevent rejection and Graft-versus-Host Disease (GvHD). In this study, we compared two rabbit ATG products, ATG-Genzyme (ATG-GENZ) ATG-Fresenius (ATG-FRES), with respect dosing, clearance of the active binding component, post-HSCT immune reconstitution clinical outcome. Fifty-eigth pediatric acute leukemia patients, (n=42 ATG-GENZ, n=16 ATG-FRES), who received...
Abstract Although most children with acute lymphoblastic leukemia (ALL) receive fractionated total body irradiation (FTBI) as myeloablative conditioning (MAC) for allogeneic hematopoietic stem cell transplantation (allo-HSCT), it is an important matter of debate if chemotherapy can effectively replace FTBI. To compare outcomes after FTBI versus chemotherapy-based (CC), we performed a retrospective EBMT registry study. Children aged 2–18 years MAC first allo-HSCT bone marrow (BM) or...
Abstract Background Patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) exhibit changes in their gut microbiota and are experiencing a range of complications, including acute graft-versus-host disease (aGvHD). It is unknown if, when, under which conditions re-establishment microbial immunological homeostasis occurs. also unclear whether long-term dynamics occur at other body sites than the such as mouth or nose. Moreover, it not known patients’ prior to HSCT holds...
Relapse remains the major cause of treatment failure in children with high-risk acute lymphoblastic leukaemia (ALL) undergoing allogeneic haematopoietic stem-cell transplantation (allo-SCT). Prognosis is considered dismal but data on risk factors and outcome are lacking from prospective studies. We analysed 242 recurrence ALL after first allo-SCT enrolled Berlin-Frankfurt-Munster (BFM) ALL-SCT-BFM 2003 international 2007 Median time to relapse was 7·7 months; median follow-up until last 3·4...
Specific protocols define eligibility, conditioning, donor selection, graft composition and prophylaxis of vs. host disease for children young adults undergoing hematopoietic stem cell transplant (HSCT). However, international rarely, if ever, detail supportive care, including pharmaceutical infection prophylaxis, physical protection with face masks cohort isolation or food restrictions. Supportive care suffers from a lack scientific evidence implementation practices in the centers brings...
Abstract Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder associated with autosomal recessive variants in genes required for perforin-mediated lymphocyte cytotoxicity. A rapid diagnosis crucial successful treatment. Although defective cytotoxic T (CTL) function causes pathogenesis, quantification of natural killer (NK)–cell exocytosis triggered by K562 target cells currently represents standard diagnostic procedure primary HLH. We have prospectively evaluated...
ABSTRACT Diagnosing acute graft‐versus‐host disease (aGvHD) following allogeneic hematopoietic stem cell transplantation (HSCT) is challenging due to heterogeneity in interpreting current clinical criteria. Recently, the Mount Sinai Acute GvHD International Consortium (MAGIC) criteria were introduced improve diagnostic consistency. In a study of 117 pediatric patients undergoing HSCT, modified Glucksberg and MAGIC retrospectively compared. The identified significantly more cases...
Highlights•Therapeutic drug monitoring (TDM) optimizes delivery and reduces toxicity risk•Asparaginase TDM detects silent inactivation helps classify real allergies•High-dose methotrexate fosters management prevention of toxicity•Thiopurine-enhanced maintenance may increase cytotoxicity by raising DNA-TG levels•TKIs should be routinely monitored, especially if or interactions arise•Busulfan AUC-measurements on day 1 occur, but added measurements are advisedAbstractTreatment regimens for...
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (HSCT) is challenged by endothelial dysfunction‐related syndromes like sinusoidal obstruction syndrome (SOS), capillary leak (CLS), and severe acute graft‐versus‐host disease (aGvHD). We investigated soluble thrombomodulin (sTM), an damage marker, in relation to dysfunction after pediatric HSCT. Procedure measured sTM levels 113 children before conditioning until Day +180 Results Plasma of increased significantly...
The output and size distribution of aerosols from dry powder inhalers are dependent on the flow rate through device. Therefore, in an vivo study, we examined flow-dependency effect formoterol when delivered a inhaler, Aerolizer, range relevant to schoolchildren. In preliminary study comprising 126 asthmatic children aged 3-10 yrs, relationship between age peak inspiratory (PIF) Aerolizer was determined. Mean PIF 104 L.min-1 all > 5 yrs performed 60 L.min-1. Sixteen 8-15 with...
Male gonadal dysfunction is a frequent late effect after pediatric hematopoietic stem cell transplantation (HSCT), but detailed insight into patterns of male function at long-term limited by retrospective studies without semen sample data. In this study, we investigated the risk azoospermia and testosterone deficiency, diagnostic value markers spermatogenesis, paternity follow-up allogeneic HSCT. All HSCT survivors age ≥18 years, transplanted in Denmark or Finland between 1980 2010, were...