A5074021202- Childhood Cancer Survivors' Quality of Life
- Reproductive Biology and Fertility
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Hemoglobinopathies and Related Disorders
- Adolescent and Pediatric Healthcare
- Immunodeficiency and Autoimmune Disorders
- Family Support in Illness
- Prenatal Screening and Diagnostics
- Oral health in cancer treatment
- Ovarian function and disorders
- Salivary Gland Disorders and Functions
- Sperm and Testicular Function
- Acute Myeloid Leukemia Research
- Air Quality and Health Impacts
- Reproductive Health and Technologies
- Cell Adhesion Molecules Research
- Pediatric Pain Management Techniques
- Blood groups and transfusion
- Immune Response and Inflammation
- Neuroscience of respiration and sleep
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Lymphocytic Leukemia Research
- Assisted Reproductive Technology and Twin Pregnancy
- Renal and related cancers
University Children’s Hospital Basel
2016-2025
University of Basel
2021-2025
University Hospital of Basel
2020
Boston Children's Hospital
2014
Massey University
2005-2013
Animal Welfare Institute
2009
Riddet Institute
2009
Gonadal impairment is an important late effect with a significant impact on quality of life transplanted patients. The aim this study was to compare gonadal function after busulfan (Bu) or treosulfan (Treo) conditioning regimens in pre- and postpubertal children. This retrospective, multicenter included children pediatric European Society for Blood Marrow Transplantation (EBMT) centers between 1992 2012 who did not receive gonadotoxic chemoradiotherapy before the transplant. We evaluated 137...
Specific protocols define eligibility, conditioning, donor selection, graft composition and prophylaxis of vs. host disease for children young adults undergoing hematopoietic stem cell transplant (HSCT). However, international rarely, if ever, detail supportive care, including pharmaceutical infection prophylaxis, physical protection with face masks cohort isolation or food restrictions. Supportive care suffers from a lack scientific evidence implementation practices in the centers brings...
The impact of hydroxyurea (HU) on the ovarian reserve female patients with sickle cell disease (SCD) remains poorly elucidated. Only direct histological analysis follicle density can effectively evaluate HU's effect reserve. By analyzing digitized slides tissue from girls and young women SCD who underwent cryopreservation (OTC) before hematological stem transplantation, we meticulously counted follicles categorized them based their growth stage. We then calculated densities different types...
Testicular tissue cryopreservation is the only option of fertility preservation in prepubertal boys. While it considered experimental, since procedures to obtain mature spermatozoa from testicular are still under development, programs have emerged worldwide. Our aim was study feasibility and safety a program adolescent boys facing gonadotoxic treatment three University hospitals Switzerland. accepted by 90% families, with total 35 patients included. The average patient age 8.5 years (range 7...
Abstract Human saliva is a complex fluid containing proteins such as salivary cytokines, which can be used for diagnostic purposes, particularly among the pediatric population. This study aimed to assess concentrations of cytokines in healthy children and adolescents determine their associations with age, sex, oral dental findings. Healthy aged 4–18 years were enrolled this cross-sectional study. The following measured by Luminex technology: IFN-γ, IL-1α, IL-1β, IL-4, IL-5, IL-6, IL-8,...
Salivary cytokines have the potential to serve as biomarkers for evaluating cancer progression and treatment response in specific types. This study explored salivary cytokine profiles pediatric patients healthy controls, examining changes during chemotherapy. We conducted a prospective involving newly diagnosed controls under 19 years old. Saliva samples were collected at diagnosis, three six months post-diagnosis patients, while provided single time point. Cytokine levels analyzed using...
Cancer and its treatments can affect dental health of childhood cancer survivors. We aimed to evaluate the prevalence problems in survivors, compare them their siblings, investigate cancer-related risk factors. As part population-based Swiss Childhood Survivor Study, we sent questionnaires inquiring about survivors aged 5-19 years siblings. retrieved cancer-relevant information from Registry used logistic regressions between siblings included 735 144 Almost half reported at least one...
Abstract Background Physical activity (PA) can reduce the risk of chronic adverse health conditions in childhood cancer survivors. We examined PA and sedentary screen time behavior a nationwide study Switzerland. Procedures The Swiss Childhood Cancer Survivor Study sent questionnaires to parents all resident ≥5‐year survivors diagnosed between 1995 2010. assessed including compulsory school sport, recreational commuting school, spent with media those aged 5‐15 years, compared results...
BackgroundBiallelic mutations in LIG4 encoding DNA-ligase 4 cause a rare immunodeficiency syndrome manifesting as infant-onset life-threatening and/or opportunistic infections, skeletal malformations, radiosensitivity and neoplasia. is pivotal during DNA repair V(D)J recombination it performs the final DNA-break sealing step.ObjectivesThis study explored whether monoallelic missense may underlie autoimmunity with autosomal dominant inheritance.MethodsExtensive flow-cytometric...
Since the 1970s outcome of aplastic anemia (AA) patients has improved significantly due to introduction immunosuppressive therapy (IST) and allogeneic hematopoietic transplantation (HCT). However, may suffer from persistent disease, relapse, clonal evolution, graft-versus-host disease other late effects. Here, we analyse very long-term all AA at our institution comparing not only survival, but also response status complications.Patient charts 302 treated between 1973 2017 University Hospital...
Abstract Background Both diagnosis and treatment of hemoglobinopathies have been associated with an increased risk fertility impairment. German guidelines recommend annual monitoring parameters to enable early detection impairment and/or offer preservation (FP) when indicated. We explored the general desire for parenthood, frequency recalling counseling testing, utilization FP in adolescents adults hemoglobinopathies. Procedure In a cross‐sectional study, patients aged 12–50 years, treated...
We investigated electroencephalographic (EEG) responses to tail clamping in lightly anaesthetized rat pups (5–22 days) order determine the ontogeny of EEG activity and at what age they may be capable experiencing pain. Median frequency (F50) spectral edge (F95) power spectrum range 1–30 Hz were determined before after application a noxious stimulus spectra compared by multivariate analysis. There was postnatal increase as, clamping, aged 5–7 days exhibited isoelectric traces, whereas those...