A5061269411- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Congenital Heart Disease Studies
- Acute Lymphoblastic Leukemia research
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Neuroblastoma Research and Treatments
- Virus-based gene therapy research
- Mesenchymal stem cell research
- Acute Myeloid Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Polyomavirus and related diseases
- Immunodeficiency and Autoimmune Disorders
- Cardiac Structural Anomalies and Repair
- Hemoglobinopathies and Related Disorders
- Monoclonal and Polyclonal Antibodies Research
- Chronic Myeloid Leukemia Treatments
- Immunotherapy and Immune Responses
- Pulmonary Hypertension Research and Treatments
- Antifungal resistance and susceptibility
- Neonatal Respiratory Health Research
- Neutropenia and Cancer Infections
- Cardiac Valve Diseases and Treatments
- RNA Interference and Gene Delivery
University Children's Hospital Tübingen
2016-2025
Temple Street Children's University Hospital
2004-2024
University of Tübingen
2014-2024
Cornell University
2024
University College London
2024
Magna Graecia University
2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2024
Bambino Gesù Children's Hospital
2024
Heinrich Heine University Düsseldorf
2004-2024
Düsseldorf University Hospital
2004-2024
AORTIC-VALVE atresia associated with mitral or stenosis, a diminutive absent left ventricle, and severe hypoplasia of the ascending aorta aortic arch make up constellation defects that was initially termed "hypoplasia tract complexes" by Lev1 later called "hypoplastic heart syndrome" Noonan Nadas.2 The anatomic complexity this cardiac malformation has been considered prohibitive long survival, generally, only supportive therapy recommended. Indeed, atresia–hypoplastic syndrome is uniformly...
In HLA-nonidentical bone marrow transplantation, we studied the characteristics of donor NK cells, recipient leukemia and cytokine environment that predict antileukemia effects allogeneic cells. We found risk relapse in pediatric patients with hematologic malignancies was best predicted by a model taking into consideration presence inhibitory killer cell Ig-like receptors (KIRs) on donor's cells absence corresponding KIR ligand recipient's HLA repertoire (a receptor-ligand model). The...
Congenital heart lesions may be complicated by pulmonary arterial smooth muscle hyperplasia, hypertrophy, and hypertension. We assessed whether inhaling low levels of nitric oxide (NO), an endothelium-derived relaxing factor, would produce selective vasodilation in pediatric patients with congenital disease also compared the vasodilator potencies inhaled NO oxygen these patients.In 10 sequentially presenting, spontaneously breathing patients, we determined 20-80 ppm volume at inspired...
Summary During periods of immunosuppression, such as postallogeneic stem cell transplantation (SCT), patients are at significant risk for severe viral infections. Human adenovirus (HAdV) infection is a serious complication post‐SCT, especially in children. Virus‐specific T cells essential the clearance HAdV, antiviral chemotherapy has revealed limited success. We present feasibility data new treatment option using virus‐specific donor adoptive transfer immunity to with...
Reactivation of Epstein-Barr virus (EBV) after allogeneic stem-cell transplantation (SCT) can lead to severe life-threatening infections and trigger post-transplantation lymphoproliferative disease (PTLD). Since EBV-specific T cells could prevent PTLD, cellular immunotherapy has been a promising treatment option. However, generation antigen-specific T-cell populations difficult within short time frame.To improve availability in urgent clinical conditions, we developed rapid protocol for...
In the last decade several therapeutic antibodies have been FDA and EMEA approved. Although their mechanisms of action in vivo is not fully elucidated, antibody-dependent cellular cytotoxicity (ADCC) mediated by natural killer (NK) cells presumed to be a key effector function. A substantial role ADCC has demonstrated vitro mouse tumour models. However, direct effect reactivity humans remains shown. Several studies revealed predictive value FcγRIIIa-V158F polymorphism monoclonal antibody...
Purpose Although hematopoietic stem-cell transplantation is widely performed in children with high-risk acute lymphoblastic leukemia (ALL), the influence of donor types poorly understood. Thus, outcomes were compared prospective multinational Berlin-Frankfurt-Muenster (BFM) study group trial: ALL-SCT-BFM 2003 (Allogeneic Stem Cell Transplantation Children and Adolescents Acute Lymphoblastic Leukemia). Patients Methods After conditioning total-body irradiation etoposide, 411 ALL received...
BackgroundExagamglogene autotemcel (exa-cel) is a nonviral cell therapy designed to reactivate fetal hemoglobin synthesis through ex vivo clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9 gene editing of the erythroid-specific enhancer region BCL11A in autologous CD34+ hematopoietic stem and progenitor cells (HSPCs).MethodsWe conducted an open-label, single-group, phase 3 study exa-cel patients 12 35 years age with transfusion-dependent β-thalassemia β0/β0, β0/β0-like,...
This study extended prior work showing abnormal affect-startle modulation in psychopaths. Male prisoners viewed specific categories of pleasant (erotic or thrilling) and unpleasant (victim direct threat) slide pictures, along with neutral pictures. Acoustic startle probes were presented early (300 800 ms) late (1,800, 3,000, 4,500 the viewing interval. At later times, nonpsychopaths showed moderate strong reflex potentiation for victim threat scenes, respectively. For psychopaths, was...
Previous research with both animal and human subjects has shown that startle reflex magnitude is potentiated in an aversive stimulus context, relative to responses elicited a neutral or appetitive context. In the present experiment, same pleasant, unpleasant, picture stimuli were repeatedly presented subjects. Startle habituation was assessed each context compared patterns of heart rate, electrodermal, facial corrugator muscle responses. All systems showed initial differentiation among...
James-Lange theory influenced a century of emotion research. This article traces the theory's origins in philosophical psychology, considers differences thinking James and Lange, assesses Cannon's early critique resulting debate. Research is reviewed evaluating physiological patterns emotion, discordance reported feelings visceral reactivity, role generalized arousal. NeoJamesian theories attribution appraisal--and alternative views based on dynamic psychology--are critically examined. A...
Purpose We recently reported that children with acute leukemias who show increasing mixed chimerism (MC) after allogeneic stem-cell transplantation have a significantly enhanced risk of relapse. Here we present the results prospective multicenter study to investigate (1) whether relapse lymphoblastic leukemia (ALL) can be determined in advance by serial analysis chimerism, and (2) if outcome influenced withdrawal immunosuppression and/or low-dose donor lymphocyte infusion when MC is...
Breast carcinoma in males is infrequent, and information regarding the results of modern treatment limited. Cases breast were accrued from multiple hospitals one region to determine treatment, survival, prognostic factors.A retrospective review was performed 217 cases accessioned at tumor registries 18 health care institutions eastern Wisconsin between 1953 1995.Of cases, 215 (99.1%) carcinomas. The majority carcinomas invasive ductal type presented as masses. Carcinoma situ accounted for...