A5046590848- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Mechanical Circulatory Support Devices
- Aortic Disease and Treatment Approaches
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital Heart Disease Studies
- Cardiac and Coronary Surgery Techniques
- Cardiac Arrest and Resuscitation
- Atrial Fibrillation Management and Outcomes
- Hemoglobin structure and function
- Cardiac electrophysiology and arrhythmias
- Trauma Management and Diagnosis
- Viral Infections and Immunology Research
- Coronary Artery Anomalies
- Cardiovascular Disease and Adiposity
- Blood transfusion and management
- Coronary Interventions and Diagnostics
Massachusetts General Hospital
2016-2025
Harvard University
2016-2025
Boston University
1994-2017
Framingham Heart Study
2017
National Heart Lung and Blood Institute
2017
Ludwig-Maximilians-Universität München
2017
Broad Institute
2017
Massachusetts Institute of Technology
1972-2017
Beth Israel Deaconess Medical Center
2017
Cleveland Clinic
2009-2017
Background Recent advances in three-dimensional (3D) echocardiography allow us to address uniquely 3D scientific questions, such as the mechanism of functional mitral regurgitation (MR) patients with left ventricular (LV) dysfunction and its relation geometry leaflet attachments. Competing hypotheses include global LV inadequate closing force versus geometric distortion apparatus by dilatation, which increases tethering restricts closure. Because changes generally accompany dysfunction,...
Acute right ventricular (RV) hypertension and failure occur clinically. In this study we examined the mechanism of RV failure. Adult dogs were studied acutely under anesthesia; instrumented for measurement pressures coronary artery blood flow. Myocardial flow cardiac output determined with radionuclide-labeled microspheres, presence ischemia was by biochemical analysis biopsies. produced constricting pulmonary increased until occurred, as evidenced decreased aortic pressure end-diastolic...
Congenital heart lesions may be complicated by pulmonary arterial smooth muscle hyperplasia, hypertrophy, and hypertension. We assessed whether inhaling low levels of nitric oxide (NO), an endothelium-derived relaxing factor, would produce selective vasodilation in pediatric patients with congenital disease also compared the vasodilator potencies inhaled NO oxygen these patients.In 10 sequentially presenting, spontaneously breathing patients, we determined 20-80 ppm volume at inspired...
Background— Functional mitral regurgitation (MR) is caused by systolic traction on the leaflets related to ventricular distortion. Little known about whether chronic tethering causes leaflet area adapt geometric needs imposed tethering, in part because of inability reconstruct vivo. Our aim was explore adaptive increases occur patients with functional MR compared normal subjects and test hypothesis that influences severity. Methods Results— A new method for 3-dimensional echocardiographic...
Background Systolic anterior motion (SAM) of the mitral valve in hypertrophic cardiomyopathy (HCM) has generally been explained by a Venturi effect related to septal hypertrophy, causing outflow tract narrowing and high velocities. Patients with HCM, however, also have primary abnormalities apparatus, including inward or central displacement papillary muscles, leaflet elongation. These findings led hypothesis that changes apparatus can be cause SAM altering forces acting on its ability move...
To elucidate the pathophysiology of severe right ventricular infarction (RVI), isolated RVI was produced in 15 dogs with pericardium intact or open. After intact, RV systolic pressure decreased by 27%, aortic 29% and cardiac output 34%. transmural pressure, end-diastolic size intrapericardial increased, left diastolic pressures equalized. Pericardiotomy after resulted increased size, improved resolution equalized pressures. open similar changes, but lesser magnitude without equalization...
Survivors of out-of-hospital cardiac arrest not associated with acute myocardial infarction are at high risk for recurrent and sudden death. The impact the implantable cardioverter-defibrillator on long-term prognosis in these patients is uncertain.Three hundred thirty-one survivors (age, 56 +/- 13.7 years) underwent electrophysiologically guided therapy. Implantable defibrillators were placed 150 (45.3%), 181 (54.7%) received pharmacological and/or surgical therapy alone. Left ventricular...
Mitral regurgitation (MR) conveys adverse prognosis in ischemic heart disease. Leaflet closure is restricted by tethering to displaced papillary muscles, and is, therefore, incompletely treated annular reduction. In an acute model, we reduced such MR cutting a limited number of critically positioned chordae the leaflet base that most restrict but are not required prevent prolapse. Whether this effective without prolapse, recurrent MR, or left ventricular (LV) failure chronic persistent...
Background This study examines the limitations and complex management problems associated with use of tiered-therapy, implantable cardioverter-defibrillators (ICDs). Methods Results The group comprises first 154 patients undergoing implantation tiered-therapy ICDs at our institution. Pulse generators from three different manufacturers were used. In 39 patients, a complete nonthoracotomy lead system was perioperative mortality 1.3%. Of these 37% experienced late postoperative problems....
Improvements in hemoglobin-based oxygen-carrying (HBOCs) solutions have overcome the toxicities that plagued earlier efforts. However, limitations of efficacy HBOCs are emerging. The potential an HBOC were studied ovine model (n = 6) exchange transfusion. Hemodynamic, oxygen transport, and hemoglobin kinetic parameters examined during isovolumic blood to a final hematocrit 3.2 +/- 0.7% plasma concentration 8.1 0.4 g/dl while sheep awake breathing room air. infusion was associated with...