A5049303025- Hemoglobin structure and function
- Anesthesia and Pain Management
- Cardiac Arrest and Resuscitation
- Heme Oxygenase-1 and Carbon Monoxide
- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Anesthesia and Sedative Agents
- Pain Management and Opioid Use
- Hemodynamic Monitoring and Therapy
- Blood transfusion and management
- Nitric Oxide and Endothelin Effects
- Hemoglobinopathies and Related Disorders
- Inflammatory mediators and NSAID effects
- Airway Management and Intubation Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Nausea and vomiting management
- Neonatal Health and Biochemistry
- Intensive Care Unit Cognitive Disorders
- High Altitude and Hypoxia
- Erythrocyte Function and Pathophysiology
- Eicosanoids and Hypertension Pharmacology
- Electroconvulsive Therapy Studies
- Thermal Regulation in Medicine
- Neuropeptides and Animal Physiology
- Parkinson's Disease and Spinal Disorders
University of California, Los Angeles
2015-2025
Ronald Reagan UCLA Medical Center
2011-2025
UCLA Health
2017-2020
John Wiley & Sons (United States)
2020
Hudson Institute
2020
Olive View-UCLA Medical Center
2015-2017
NHS Lothian
2016
Los Angeles Medical Center
2009
UCLA Medical Center
2009
Island Institute
2008
Intravenous acetaminophen injection (paracetamol) is marketed in Europe for the management of acute pain. A repeated-dose, randomized, double-blind, placebo-controlled, three-parallel group study was performed to evaluate analgesic efficacy and safety intravenous as compared with its prodrug (propacetamol) placebo. Propacetamol has been available many European countries more than 20 yr.After orthopedic surgery, patients reporting moderate severe pain received either 1 g acetaminophen, 2...
Background Rocuronium in intubation doses provides similar conditions as succinylcholine, but has a longer duration of action. This study compared time to sugammadex reversal profound rocuronium-induced neuromuscular block with spontaneous recovery from succinylcholine. Methods One hundred and fifteen adult American Society Anesthesiologists Class I-II surgical patients were randomized this multicenter, safety-assessor-blinded, parallel group, active-controlled, Phase IIIa trial. Anesthesia...
Background: The ability of hemoglobin based oxygen carrier-201 (HBOC-201) to safely reduce and/or eliminate perioperative transfusion was studied in orthopedic surgery patients. Methods: A randomized, single-blind, packed red blood cell (PRBC)-controlled, parallel-group multicenter study conducted. Six hundred eighty-eight patients were randomized treatment with HBOC-201 (H, n = 350) or PRBC (R, 338) at the first decision. Primary endpoints avoidance and blinded assessment [Mann-Whitney...
Hemoglobin-based oxygen carriers (HBOCs) have a long history of development, yet none are currently licensed for use in the US. Early HBOC studies were interested toxicity infused hemoglobin, followed by Amberson and colleagues from University Maryland.1 As early as 1934, purified bovine hemoglobin it into cats. In 1949, he described human anemic parturients with hemorrhage after childbirth.2 Development continued when US Army manufactured tetrameric cross-linked (α-α hemoglobin), which...
Abstract Background and Methods: From the time that Sinatra et al. ( Anesthesiology . 2005; 102 :822) was published to FDA apaproval of intravenous (IV) acetaminophen, an expanded analysis original raw study data became necessary for regulatory submission. The following analyses were conducted: (1) sum pain intensity differences over 24 hours (SPID24) using currently accepted imputation methods account both missing effects rescue; (2) efficacy results after first 6 hours; (3) gender,...
Hemopure (hemoglobin glutamer-250 [bovine]; HBOC-201) is a hemoglobin (Hb)-based oxygen carrier registered with the Medicines Control Council of South Africa. It indicated for treatment adult patients who are acutely anemic, purpose maintaining tissue delivery thus eliminating, delaying, or reducing need allogeneic red blood cells (RBCs). volume expander, and circulatory must be carefully monitored signs fluid overload. not as effective RBCs restoring Hb content concentration, but in cases...
Despite advances in pharmacologic options for the management of surgical pain, there appears to have been little or no overall improvement over last two decades level pain experienced by patients. The importance adequate and effective management, however, is clear, because inadequate control 1) has a wide range undesirable physiologic immunologic effects; 2) associated with poor outcomes; 3) increased probability readmission; 4) adversely affects cost care as well patient satisfaction. There...
Navalgund, Ashok A. MD; Kang, Yoogoo Sarner, Joel B. Jahr, Jonathan S. Gieraerts, Roland MD Author Information
Inadequate control of postoperative pain after orthopedic procedures may trigger complications that increase morbidity. Multimodal analgesia is used to manage effectively surgical and reduce the need for rescue analgesia. Intravenous (IV) acetaminophen (OFIRMEV; Cadence Pharmaceuticals, Inc.), an analgesic has been studied in multimodal management acute major procedures, combines safety seen with oral rectal formulations a preferred route administration. Two double-blind, randomized,...
Perflurocarbon-based oxygen carriers (PBOC) represent a major category of artificial therapeutics. Since their initial report potential oxygen-carrying capability half century ago, some PBOC products have been developed for the purpose Unfortunately, majority these discontinued due to side effects, such as Flusol-DA-20, Oxygent, and Oxycyte. is unique its inorganic nature relatively smaller molecules, making it possible production in massive quantity. Perftoran was Moscow, Russia, approved...
Clinical features: Sickle cell patients may develop a multitude of antibodies and experience life-threatening events with transfusion such as hyperhemolysis syndrome or delayed hemolytic reaction. Further not be possible in cases. Therapeutic Challenge: When conventional blood products are available for yet the patient requires additional oxygen-carrying support, artificial oxygen carriers required. However, there no FDA-approved available. Solution: Emergency investigational new drug...