A5102712870- Transplantation: Methods and Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital Heart Disease Studies
- Renal Transplantation Outcomes and Treatments
- Mechanical Circulatory Support Devices
- Infective Endocarditis Diagnosis and Management
- Organ Transplantation Techniques and Outcomes
- Viral Infections and Immunology Research
- Coronary Artery Anomalies
- Cardiac tumors and thrombi
- Cardiac Arrest and Resuscitation
- Aortic Disease and Treatment Approaches
- Coronary Interventions and Diagnostics
- Tracheal and airway disorders
- Cardiac Imaging and Diagnostics
- Organ and Tissue Transplantation Research
- Polyomavirus and related diseases
- Cardiac Ischemia and Reperfusion
- Cardiac Arrhythmias and Treatments
- Cardiomyopathy and Myosin Studies
- Venous Thromboembolism Diagnosis and Management
- Ethics in Business and Education
Cleveland Clinic
1996-2022
NIHR Surgical Reconstruction and Microbiology Research Centre
2019
Biomedical Research Institute
2019
University of Zagreb
2019
University of Houston
1981-2012
Walter Reed Army Institute of Research
2008-2010
Baghdad Medical City
2008
Mayo Clinic Hospital
2007
Northwestern University
2006
University Hospitals of Cleveland
1999-2004
We compared patients who received an internal-mammary-artery graft to the anterior descending coronary artery alone or combined with one more saphenous-vein grafts (n = 2306) had only bypass 3625). The 10-year actuarial survival rate among group receiving graft, as vein (exclusive of hospital deaths), was 93.4 percent versus 88.0 (P 0.05) for those one-vessel disease; 90.0 79.5 (P<0.0001) two-vessel and 82.6 71.0 three-vessel disease. After adjustment demographic clinical differences by Cox...
Reduced preload and afterload to the heart are important effects of angiotensin converting enzyme (ACE) inhibitors in treatment congestive failure. However, since II (Ang II) directly increases strength myocardial contraction, suppression Ang formation by ACE could potentially reduce beneficial on failing heart. To study how inhibition suppresses cardiac man, we characterized ACE-dependent ACE-independent II-forming pathways eight normal 24 human hearts obtained at transplantation. activity...
The mechanisms of chronic atrial fibrillation (AF) are not well understood. We performed epicardial mapping AF in patients undergoing open heart surgery to test the hypothesis that is due a left "driver" with regular, short cycle length, resulting fibrillatory conduction rest atria.Nine (1 month >15 years' duration) were studied at surgery, 8 before and 1 during cardiopulmonary bypass. During AF, electrograms (AEGs) recorded for 5 minutes from 404 electrodes arranged bipoles along ECG lead...
We analyzed trends in clinical, angiographic, and operative variables documented long-term survival 2509 consecutive patients who underwent reoperation for myocardial revascularization at The Cleveland Clinic during a 20-year period (1967 to 1987). were grouped into four cohorts by year of surgery. This analysis showed that vein graft atherosclerosis has become the leading indication reoperation, patient age interval between operations continue increase. Mortality rates ranged from 2% 5%...
To demonstrate the existence and help clarify function of angiotensin II (Ang II) receptors in human heart, we characterized cardiac Ang receptor examined levels distribution ventricular normal (n = 6) failing 14) hearts. were using agonist [125I]Ang II. Cardiac II-binding sites high affinity (Kd, ∼ 1 nmol/L) low capacity (Bmax, 3 fmol/mg membrane protein) pharmacologically specific [IC50 values for II, [Sar1Ile8]Ang III 1.2, 3.0, 400 nmol/L, respectively; inactive metabolite Ang-(1–5), at a...
The direct effects of angiotensin II (Ang II) on human cardiac muscle were investigated using isolated trabecular muscles from failing and functionally normal hearts. Atrial ventricular trabeculae studied. Results demonstrated a positive inotropic effect Ang muscle. Comparison the among groups indicated that responsiveness tended to be greater in atrial compared with this study also heterogeneity muscles, which was not correlated patient age, sex, diagnosis, prior treatment converting enzyme...
Background —Most studies indicate that failing human hearts have greater baseline myofibrillar Ca 2+ sensitivity of tension development than nonfailing hearts. Phosphorylation cardiac troponin I (TnI) by cAMP-dependent protein kinase (PKA) decreases the affinity complex for , thus altering force production. We tested hypothesis PKA-dependent TnI phosphorylation is altered in heart and investigated changes PKA regulatory subunits as a potential mechanism. Methods Results —Using vitro...
A total of 5,070 patients 65 years age or older underwent primary elective coronary bypass surgery at The Cleveland Clinic Foundation from January 1976 through June 1986. These were divided by into two groups, 65-74 and 75 older; these groups compared with each other younger than years. With advancing age, there was a significantly greater prevalence women, more severe angina, diabetes, peripheral vascular disease, previous cerebral events, cardiac enlargement, left main artery disease....