A5055036012- Hematopoietic Stem Cell Transplantation
- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Virus-based gene therapy research
- Polyomavirus and related diseases
- Renal Transplantation Outcomes and Treatments
- Acute Myeloid Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Mesenchymal stem cell research
- Parvovirus B19 Infection Studies
- Neutropenia and Cancer Infections
- CAR-T cell therapy research
- Educational Games and Gamification
- Reproductive Biology and Fertility
- Adolescent and Pediatric Healthcare
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Transplantation: Methods and Outcomes
- Viral gastroenteritis research and epidemiology
- Corneal Surgery and Treatments
- Mobile Health and mHealth Applications
- Bone and Joint Diseases
St Anna Children's Hospital
2016-2025
Medical University of Vienna
2014-2024
St. Anna Children's Cancer Research Institute
2016-2023
Boston Children's Hospital
2005-2015
Pediatrics and Genetics
2014
University of Regensburg
2011
University of Freiburg
2011
University Hospital of Basel
2011
In 2005, the National Institutes of Health (NIH) Chronic Graft-versus-Host Disease (GVHD) Consensus Response Criteria Working Group recommended several measures to document serial evaluations chronic GVHD organ involvement. Provisional definitions complete response, partial and progression were proposed for each overall outcome. Based on publications over last 9 years, 2014 has updated its recommendations interpretation responses. Major changes include elimination clinical parameters from...
Steroid refractory chronic graft-versus-host disease (cGVHD) is associated with a significant morbidity and mortality. Although first-line treatment of cGVHD based on controlled trials, second-line almost solely phase II trials or retrospective analyses. The consensus conference clinical practice in held Regensburg aimed to achieve the current evidence options as well provide guidelines for daily practice. Treatment modalities are use steroids calcineurin inhibitors immunomodulating...
<h3>Background</h3> Immunodysregulation polyendocrinopathy enteropathy x-linked (IPEX) syndrome is a monogenic autoimmune disease caused by <i>FOXP3</i> mutations. Because it rare disease, the natural history and response to treatments, including allogeneic hematopoietic stem cell transplantation (HSCT) immunosuppression (IS), have not been thoroughly examined. <h3>Objective</h3> This analysis sought evaluate onset, progression, long-term outcome of 2 main treatments in IPEX survivors....
The 2006 National Institutes of Health (NIH) Consensus paper presented recommendations by the Ancillary Therapy and Supportive Care Working Group to support clinical research trials in chronic graft-versus-host disease (GVHD). Topics covered that inaugural effort included prevention management infections common complications GVHD, as well for patient education appropriate follow-up. Given new literature has emerged during past 8 years, we made further organ-specific refinements these...
Recognition of the earliest signs and symptoms chronic graft-versus-host disease (GVHD) that lead to severe manifestations remains a challenge. The standardization provided by National Institutes Health (NIH) 2005 2014 consensus projects has helped improve diagnostic accuracy severity scoring for clinical trials, but utilization these tools in routine practice is variable. Additionally, when patients meet NIH criteria, many already have significant morbidity possibly irreversible organ...
ABSTRACT A panel of 23 real-time PCR assays based on Taq Man technology has been developed for the detection and monitoring 16 different viruses virus families including human polyomaviruses BK JC virus, herpesviruses 6, 7, 8, adenoviruses, herpes simplex 1 2, varicella-zoster cytomegalovirus, Epstein-Barr parvovirus B19, influenza B viruses, parainfluenza to 3, enteroviruses, respiratory syncytial virus. The test systems presented have a broad dynamic range display high sensitivity,...
Chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation is still associated with significant morbidity and mortality. First-line treatment of cGVHD based on steroids 1 mg/kg/day prednisone. The role calcineurin inhibitors remains controversial, especially in patients low risk for mortality (normal platelets counts), whereas at diagnosis and/or high steroid toxicity may be treated upfront the combination prednisone a inhibitor. Additional systemic...
Ocular chronic graft-versus-host disease (cGVHD) is one of the most frequent long-term complications after hematopoietic stem cell transplantation and often associated with significant morbidity reduced quality life.The German/Austrian/Swiss Consensus Conference on Clinical Practice in cGVHD aimed to summarize currently available evidence for diagnosis (topical) treatment different modalities ocular cGVHD. The presented consensus was based a review published survey current clinical practice...
Abstract Chronic graft-versus-host disease (cGVHD) and late acute (L-aGVHD) are understudied complications of allogeneic hematopoietic stem cell transplantation in children. The National Institutes Health Consensus Criteria (NIH-CC) were designed to improve the diagnostic accuracy cGVHD better classify (GVHD) syndromes but have not been validated patients &lt;18 years age. objectives this prospective multi-institution study determine: (1) whether NIH-CC could be used diagnose pediatric...