A5068465972- Research on Leishmaniasis Studies
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Trypanosoma species research and implications
- T-cell and B-cell Immunology
- Brucella: diagnosis, epidemiology, treatment
- Acute Lymphoblastic Leukemia research
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Cytomegalovirus and herpesvirus research
- Acute Myeloid Leukemia Research
- Pesticide Exposure and Toxicity
- Galectins and Cancer Biology
- Tuberculosis Research and Epidemiology
- Childhood Cancer Survivors' Quality of Life
- Diagnosis and treatment of tuberculosis
- Vitamin C and Antioxidants Research
- Effects of Radiation Exposure
- Neutropenia and Cancer Infections
- Urticaria and Related Conditions
- Free Radicals and Antioxidants
- Renal Transplantation Outcomes and Treatments
- Antioxidant Activity and Oxidative Stress
- Leptospirosis research and findings
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
University of Washington
2024
British Columbia Children's Hospital
2011-2023
University of British Columbia
2011-2022
Child and Family Research Institute
2012-2017
Pasteur Institute of Iran
2001-2009
Institut Pasteur de la Guyane
2003-2007
In the present study, we show for first time that lipophosphoglycan (LPG) stimulated cytokine production by human peripheral blood mononuclear cells is also mediated via Toll-like receptor (TLR2). addition, in order to verify if TLR2 involved recognition of purified PGs, neutralizing mAbs against and TLR4 were used treat before being with PGs. We found strong Th1-promoting cytokines induced sLPG but not mLPG which was blocked presence anti-TLR2 mAb. This finding reveals a mechanism encounter...
Numerous mechanisms underlie chronic graft-versus-host disease (cGVHD), including skewing of Th1/Th2 cytokine expression. There are biological differences between early-onset and late-onset cGVHD. To test whether different cytokines associated with early- or cGVHD, peripheral blood was collected from 63 children enrolled on the Children's Oncology Group Phase III trial ASCT0031 evaluating hydroxychloroquine therapy for newly diagnosed extensive mRNA expression interferon (IFN)-γ interleukin...
In adult hematopoietic cell transplantation (HCT), filgrastim-mobilized peripheral blood (G-PB) has largely replaced unstimulated marrow for allografting. Although the use of G-PB results in faster recovery, it is also associated with more chronic graft-versus-host disease (cGVHD). A potential alternative allograft filgrastim-stimulated (G-BM), which we hypothesized may be prompt recovery but less cGVHD. We conducted a phase 3, open-label, multicenter randomized trial 230 adults hematologic...
It is established that pediatric hematopoietic stem cell transplant (HSCT) recipients have a lower rate of chronic graft-versus-host disease (cGvHD) compared to adults. Our group has previously published immune profiles changes associated with cGvHD clinically well-defined adult and HSCT cohorts. Since all analyses were performed by the same research analyzed using identical methodology, we first our previous profile between adults children. We then additional comparing T populations across...
In this study, we compared the potencies of diosgenin, a plant-derived sapogenin structurally similar to estrogen and progesterone, on vascular smooth muscle functions ranging from contraction migration apoptosis. The effects diosgenin cell viability were measured using primary mouse aortic culture. calcium signaling investigated in isolated aorta wire myography confocal microscopy, respectively. Here, report that cultured cells (≥25 μM) induces apoptosis as by number annexin V-positive...
Randomized trials have conclusively shown higher rates of chronic graft-versus-host disease with filgrastim-stimulated apheresis peripheral blood as a donor source than unstimulated bone marrow. The Canadian Blood and Marrow Transplant Group conducted phase 3 study adults who received either or marrow from human leukocyte antigen-identical sibling donors. Because all donors the identical filgrastim dosing schedule, this allowed for controlled evaluation impact stem cell on development...
Previous studies have reported single B cell-related chronic graft-versus-host disease diagnostic (cGVHD) biomarkers, such as cell-activating factor (BAFF), CD21low, and immature cells, but research on the performance of biomarker combinations covariate effect steroids is lacking. The primary objective this study was to determine most accurate combination cell populations using surface staining flow cytometry in an independent cohort patients with cGVHD. Secondary objectives included...
Reports of spontaneous acute lymphoblastic leukemia (ALL) remissions following severe bacterial infections suggest that components may trigger elimination ALL. To date, TLR2, which recognizes a broad range pathogens through TLR1 or TLR6 heterodimerization, has not been fully evaluated for direct effects on Studies investigating TLR2 signaling in other tumor cell types utilizing single ligands have yielded contradictory results, and comparative, heterodimer-specific analyses stimulation are...