Anna Pawłowska
A5078986373- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Cutaneous lymphoproliferative disorders research
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- Acute Myeloid Leukemia Research
- Renal Diseases and Glomerulopathies
- Fungal Infections and Studies
- Immune Cell Function and Interaction
- Hemoglobinopathies and Related Disorders
- Complement system in diseases
- Prenatal Screening and Diagnostics
- Transplantation: Methods and Outcomes
- Parvovirus B19 Infection Studies
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
- Mesenchymal stem cell research
- Platelet Disorders and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Renal Transplantation Outcomes and Treatments
- Renal and related cancers
- Neurogenetic and Muscular Disorders Research
University of Warmia and Mazury in Olsztyn
2011-2025
City of Hope
2011-2024
City Of Hope National Medical Center
2010-2024
Medical University of Lublin
2022-2023
Pediatrics and Genetics
2020
Uniwersytecki Szpital Kliniczny w Olsztynie
2020
Poznan University of Medical Sciences
2016
Hypertension Institute
2013
University of Computer Sciences and Economics in Olsztyn
2011
University of Minnesota
1996-2001
Abstract Chronic graft-versus-host disease (cGVHD) and late acute (L-aGVHD) are understudied complications of allogeneic hematopoietic stem cell transplantation in children. The National Institutes Health Consensus Criteria (NIH-CC) were designed to improve the diagnostic accuracy cGVHD better classify (GVHD) syndromes but have not been validated patients <18 years age. objectives this prospective multi-institution study determine: (1) whether NIH-CC could be used diagnose pediatric...
Current conditioning regimens provide insufficient disease control in relapsed/refractory acute leukemia patients undergoing hematopoietic stem cell transplantation (HSCT) with active disease. Intensification of chemotherapy and/or total body irradiation (TBI) is not feasible because excessive toxicity. Total marrow and lymphoid (TMLI) allows for precise delivery increased intensity treatment via sculpting radiation to sites high burden or risk involvement, while sparing normal tissue. We...
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) predominantly occurs in adults ≥60 years old; 10-20% of cases are pediatric or adolescent/young adult (AYA) patients. Tagraxofusp (TAG, Elzonris
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a highly aggressive hematological malignancy with extremely poor outcome. The median overall survival for adult patients 9–13 months. Pediatric are exceedingly rare an unclear clinical course. Currently, no standardized therapy has been established, although acute lymphoblastic leukemia type of treatment appears to be more effective in those who able tolerate chemotherapy. SL-401 targeted directed CD123, protein ubiquitously expressed...
Allogeneic stem cell transplantation (HCT) is curative in patients with severe sickle disease (SCD), but a significant number of lack an HLA-identical sibling or matched unrelated donor. Mismatched related (haploidentical) HCT post-transplant cyclophosphamide (PTCY) allows expansion the donor pool complicated by high rates graft failure. In this report we describe favorable haploidentical approach limited cohort SCD comorbidities. To reduce risk failure administered conditioning regimen...
Abstract Background Transplant‐associated thrombotic microangiopathy (TMA) syndromes are reported to occur with increased frequency in transplant patients treated siroliumus combined a calcineurin inhibitor. We performed retrospective study of all pediatric at City Hope who were administered tacrolimus/sirolimus (TAC/SIR) determine the occurrence TMA. Procedure This analysis includes 41 consecutive between ages 2 and 20 (median age 9.1) received an allogeneic hematopoietic stem cell from any...
Dickkopf 3 (Dkk3) is a WNT/β-catenin signaling pathway regulator secreted by tubular epithelial cells upon the influence of different stressors. Recently Dkk3 was described as biomarker cell injury and tool that may estimate risk chronic kidney disease (CKD) progression. The data about concentrations at particular stages CKD are lacking. aim this study to measure serum urine levels in patients with 'renal status' evaluate its role renal damage. One hundred individuals, aged between 24 85...
The National Institutes of Health Consensus criteria for chronic graft-versus-host disease (cGVHD) diagnosis can be challenging to apply in children, making pediatric cGVHD difficult. We aimed identify diagnostic biomarkers that would complement the current clinical and help differentiate from non-cGVHD. Applied Biomarkers Late Effects Childhood Cancer (ABLE) study, open at 27 transplant centers, prospectively evaluated 302 patients after hematopoietic cell (234 evaluable). Forty-four...
Little is known about the risk of post-COVID-19 multisystem inflammatory syndrome in children (MIS-C) setting childhood cancer.
Background Factor H-related protein 5 (FHR-5) is a member of the complement H family. Due to homology H, main regulator alternative pathway, it may also be implicated in pathomechanism kidney diseases where and pathway dysregulation play role. Here, we report first observational study on CFHR5 variations along with serum FHR-5 levels immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) C3 glomerulopathy (C3G) patients together clinical, genetic, complement, follow-up...
Abstract Background Acquired or genetic abnormalities of the complement alternative pathway are primary cause C3glomerulopathy(C3G) but may occur in immune-complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) as well. Less is known about presence and role C4nephritic factor(C4NeF) which stabilize classical C3-convertase. Our aim was to examine C4NeF its connection with clinical features other pathogenic factors. Results One hunfe IC-MPGN/C3G patients were enrolled study....