A5005043216- Platelet Disorders and Treatments
- Hemophilia Treatment and Research
- Blood Coagulation and Thrombosis Mechanisms
- Acute Lymphoblastic Leukemia research
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Adolescent and Pediatric Healthcare
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Hemoglobinopathies and Related Disorders
- Dialysis and Renal Disease Management
- Venous Thromboembolism Diagnosis and Management
- Blood groups and transfusion
- Central Venous Catheters and Hemodialysis
- Parvovirus B19 Infection Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer, Hypoxia, and Metabolism
- Obsessive-Compulsive Spectrum Disorders
- Hematopoietic Stem Cell Transplantation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Effects of Radiation Exposure
- Erythropoietin and Anemia Treatment
- Blood disorders and treatments
- Kawasaki Disease and Coronary Complications
- Intraperitoneal and Appendiceal Malignancies
MedStar Georgetown University Hospital
2021-2024
Georgetown University
2021-2024
Feinstein Institute for Medical Research
2023
Northwell Health
2023
Cohen Children's Medical Center
2012-2021
Schneider Children's Hospital
2012-2021
Novant Health
2018
Deen Dayal Upadhyay Hospital
2016
University of California, Davis
2010
Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening, hyperinflammatory syndrome. Emapalumab, fully human monoclonal antibody that neutralizes the proinflammatory cytokine interferon gamma, approved in United States to treat primary HLH (pHLH) patients with refractory, recurrent, or progressive disease, intolerance conventional treatments. REAL-HLH, retrospective study, conducted across 33 US hospitals, evaluated real-world treatment patterns and outcomes treated ≥1 dose of...
von Hippel-Lindau (VHL) protein is the principal negative regulator of hypoxia sensing mediated by transcription factors. Mutations in exon 3 VHL gene lead to Chuvash (VHL(R200W)) and Croatian (VHL(H191D)) polycythemias. Here, we describe an infant Bangladesh ethnicity with a novel homozygous VHL(D126N) mutation congenital polycythemia dramatically elevated erythropoietin (EPO) levels, who developed severe fatal pulmonary hypertension. In contrast polycythemia, erythroid progenitors (BFU-Es)...
Little is known about the risk of post-COVID-19 multisystem inflammatory syndrome in children (MIS-C) setting childhood cancer.
Abstract Deficiency of coagulation factor VIII in hemophilia A disrupts clotting and prolongs bleeding. While the current mainstay therapy is infusion concentrates, inhibitor antibodies often render these ineffective. Because preclinical evidence shows electrical vagus nerve stimulation accelerates to reduce hemorrhage without precipitating systemic thrombosis, we reasoned it might bleeding A. Using two different male murine thrombosis models, show bypasses deficiency decrease accelerate...
Abstract Alpha thalassemia due to nondeletional mutations usually leads more severe disease than that caused by deletional mutations. Devastating outcomes such as hydrops fetalis can occur with two mutations, therefore warranting DNA‐based workup for suspected carriers subtle hematological abnormalities family counseling purposes. We describe three cases hemoglobin (Hb) Adana, a alpha chain mutation, compounded an globin gene deletion resulting in intermedia. review the literature, draw...
Rheumatologic disease-associated hemophagocytic lymphohistiocytosis (HLH), a rare, life-threatening, systemic hyperinflammatory syndrome, occurs as complication of underlying rheumatologic disease. Real-world evidence is lacking on emapalumab, fully human monoclonal antibody that neutralizes the proinflammatory cytokine interferon-γ, approved for treating patients with primary HLH.
A young female having complaints of quadriparesis along with bladder and bowel involvement, diagnosed to have osseous destruction C4, C6, C7, T2 vertebral bodies pre- para-vertebral abscess, was taken up for anterolateral decompression fusion cervical spine. She presented anxiety, agitation, sweating headache in hypertensive crisis which refractory antihypertensives, anxiolytics analgesics but showed a reasonable response intravenous dexmedetomidine finally responded dramatically rectal...
The goal of our project is to develop a unique ligand-conjugated nanoparticle (NP) therapy against childhood acute lymphoblastic leukemia (ALL). LLP2A, discovered by Dr. Kit Lam, high-affinity and high-specificity peptidomimetic ligand an activated α4β1 integrin. Our study using 11 fresh primary ALL samples (10 precursor B 1 T ALL) showed that cells expressed integrin bound LLP2A. Normal hematopoietic such as lymphocytes monocytes integrin; however, normal stem low expression Therefore, we...
Children with malignant mediastinal masses have increased thrombotic events (TE). Eligible subjects between January 2000 and December 2017 were evaluated for TE, 19 among 76 receiving enoxaparin thromboprophylaxis. There 13 TEs an incidence of 17.1%. Mediastinal compression directly led to TE in 9.2% who also had statistically significant superior vena cava at diagnosis. Primary thromboprophylaxis did not significantly affect occurrence; however, larger studies are warranted consider...
Background: Cycloid Psychosis is a diagnosis which emerged from the Wernicke-Kleist-Leonhard school of psychiatry and has long history in Europe. Despite an estimated incidence up to 15% first psychotic episodes, well-established diagnostic criteria with high discriminant validity, unique disease course, demonstrated biomarkers, this remains relatively unknown North American as it not included DSM-5 or ICD-10. Review available literature, especially work by Leonhard, Perris, Peralta, amongst...
Radiation-induced hemorrhagic gastritis is a serious and rare complication of radiation therapy. Optimal therapies in the pediatric population are not well established. We report 2-year-old female diagnosed with rhabdomyosarcoma who developed following chemotherapy The patient presented acute onset anemia, hematemesis, melena. Endoscopies revealed circumferential ulceration at pylorus spontaneous oozing that failed to respond effectively multimodal medical endoscopic therapies. Following...