A5071713469- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Adolescent and Pediatric Healthcare
- Pharmaceutical studies and practices
- Acute Myeloid Leukemia Research
- Palliative Care and End-of-Life Issues
- COVID-19 and healthcare impacts
- Patient Safety and Medication Errors
- Inflammatory mediators and NSAID effects
- Ethics and Legal Issues in Pediatric Healthcare
- Glioma Diagnosis and Treatment
- Family Support in Illness
- Chronic Myeloid Leukemia Treatments
- Pharmaceutical Practices and Patient Outcomes
- Intensive Care Unit Cognitive Disorders
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Protein Degradation and Inhibitors
- PI3K/AKT/mTOR signaling in cancer
- Health Sciences Research and Education
- Neutropenia and Cancer Infections
- Protein Tyrosine Phosphatases
- Protein Kinase Regulation and GTPase Signaling
- Histone Deacetylase Inhibitors Research
- Cancer Genomics and Diagnostics
University of Iowa
2020-2025
University of Iowa Hospitals and Clinics
2021-2025
Nationwide Children's Hospital
2024
University of Iowa Stead Family Children’s Hospital
2023-2024
University of Iowa Health Care
2024
Hinds Community College
2024
Bell (Canada)
2024
University of Iowa Holden Comprehensive Cancer Center
2020
Corewell Health Blodgett Hospital
2012-2018
Spectrum Health
2012-2018
Systemic exposure to mercaptopurine (MP) is critical for durable remissions in children with acute lymphoblastic leukemia (ALL). Nonadherence oral MP could increase relapse risk and also contribute inferior outcome Hispanics. This study identified determinants of adherence described impact on relapse, both overall by ethnicity.
Abstract Targeting critical epigenetic regulators reverses aberrant transcription in cancer, thereby restoring normal tissue function 1–3 . The interaction of menin with lysine methyltransferase 2A (KMT2A), an regulator, is a dependence acute leukaemia caused by either rearrangement KMT2A or mutation the nucleophosmin 1 gene ( NPM1 ) 4–6 rearrangements occur up to 10% leukaemias and have adverse prognosis, whereas mutations 30%, forming most common genetic alteration myeloid 7,8 Here, we...
Revumenib, an oral, small molecule inhibitor of the menin-lysine methyltransferase 2A (KMT2A) interaction, showed promising efficacy and safety in a phase I study heavily pretreated patients with
Purpose: Stagnant outcomes for adolescents and young adults (AYAs; 15 to 39 years old) with cancer are partly attributed poor enrollment onto clinical trials. The National Cancer Institute (NCI) Community Clinical Oncology Program (CCOP) was developed improve trial participation in the community setting, where AYAs most often treated. Further, many CCOP sites had pediatric medical oncologists collaborative potential AYA recruitment care. For these reasons, we hypothesized that enrolled...
PURPOSE Medication prior authorization (mPA) occurs commonly in US cancer care. While medical oncologists report potential harm resulting from this requirement, the impact of mPA pediatric oncology is unknown. This study's primary aim was to test feasibility prospectively collecting multi-institutional data on oncology, while secondarily assessing for resultant delays METHODS Pediatric patients with were enrolled between September 2021 and December 2022 at three Children's Oncology Group...
The median life expectancy of people with Down syndrome has increased substantially over the past several decades, from 4 years in 1970 to 53 2010. Despite recent improvement survival, there is little data about prevalence age-related diseases, including malignancies, and impact standard cancer treatments on cardiovascular health. We retrospectively reviewed medical records for age- sex-matched patients >/= 15 old without using TriNetX platform identify malignancies explore outcomes after...
Purpose Children with acute lymphoblastic leukemia (ALL) are generally instructed to take mercaptopurine (6-MP) in the evening and without food or dairy products. This study examines association between 6-MP ingestion habits adherence, red cell thioguanine nucleotide (TGN) levels, risk of relapse children TMPT wild-type genotype. Methods Participants included 441 ALL receiving oral for maintenance. Adherence was monitored over 48,086 patient-days using Medication Event Monitoring System;...
Therapies for metastatic pediatric sarcomas have reached maximum tolerated doses, but continue to provide suboptimal cure rates. Additionally, these treatments are associated with numerous short- and long-term side effects. Therefore, the search newer, less toxic therapeutic agents is warranted. Overexpression of inducible enzyme, cyclooxygenase-2 (COX-2), has been discovered in a variety adult solid tumors studies shown COX-2 inhibitors significant antiproliferative we sought determine...
Although pediatric hospice care is commonly accepted as a beneficial intervention, the incremental advantage over end-of-life delivered without engaging remains unknown. The primary objective of this study was to describe differences in when with and support, perceived by medical provider.A retrospective survey providers conducted 2005 2-month period at single institution, Helen DeVos Children's Hospital (HDVCH). Medical self-determined experience were asked separately provide positive...
The pharmacological properties and signaling of angiotensin IV (ANG IV) receptors were studied in opossum kidney cell line OK7A. Saturation binding experiments with 125I-labeled ANG demonstrated the presence high-affinity sites OK7A membranes a dissociation constant (Kd) 0.40 +/- 0.08 nM maximal amount (Bmax) 180 50 fmol/mg protein. In competition experiments, unlabeled inhibited 125I-ANG biphasically: 20% had high affinity [inhibition (Ki) = 0.44 0.04 nM] 80% low (Ki 130 10 nM). III...
Abstract Background Medication prior authorization (PA) is a commonly occurring requirement, particularly for medications used rare conditions. Based on standard definitions, cancer and many blood disorders affecting children are rare. The study aims were to describe the relative frequency of PA requests their association with payers in order identify opportunities improve system efficiency. Procedure Requests medication logged prospectively patients seen at single institution over 7‐month...
The Pediatric Oncology COVID-19 Case Report registry supplies pediatric oncologists with data surrounding the clinical course and outcomes in children cancer SARS-CoV-2.This observational study captured sociodemographic characteristics for (≤ 21 years) receiving therapy infected SARS-CoV-2 from pandemic onset through February 19, 2021. demographic of cohort were compared population-level oncology (SEER). Multivariable binomial regression models evaluated patient associated hospitalization,...
Obesity at diagnosis of childhood acute lymphoblastic leukemia (ALL) is associated with greater risk relapse; whether this association extends to obesity during maintenance unstudied.
Little is known about the risk of post-COVID-19 multisystem inflammatory syndrome in children (MIS-C) setting childhood cancer.
Individuals diagnosed with cancer between 15 and 39 years (adolescent young adult [AYA]) face unique vulnerability. Detail is lacking about care delivery for these patients, especially those ALL. We address knowledge gaps by describing AYA ALL details at National Cancer Institute Community Oncology Research Program (NCORP) (sub)affiliates model of care.
Purpose To determine if expression of cyclooxygenase (COX)-2, an inducible enzyme with known tumor-promoting activity, correlates outcome in pediatric sarcomas. COX-2 overexpression more aggressive disease a variety adult solid tumors. Methods Archived human osteosarcoma, rhabdomyosarcoma, and Ewing sarcoma tumors were retrospectively evaluated, blinded to outcome, for by immunohistochemistry correlated patient characteristics survival. Results was detected 94 142 (66%) (osteosarcoma, 66/99...
Sequencing introns in cancer predisposition genes detects novel loss-of-function variants.