A5066899131- Congenital Diaphragmatic Hernia Studies
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Testicular diseases and treatments
- RNA Interference and Gene Delivery
- Ferroptosis and cancer prognosis
- Congenital heart defects research
- Glioma Diagnosis and Treatment
- Genetic and Kidney Cyst Diseases
- Renal and related cancers
- Genetic Syndromes and Imprinting
- Circular RNAs in diseases
The University of Texas Southwestern Medical Center
2018-2023
Southwestern Medical Center
2023
Texas Woman's University
2017
Many childhood Wilms tumors are driven by mutations in the microRNA biogenesis machinery, but mechanism which these drive tumorigenesis is unknown. Here we show that transcription factor pleomorphic adenoma gene 1 (PLAG1 ) a target overexpressed with processing genes. can also overexpress PLAG1 through copy number alterations, and expression correlates prognosis tumors. overexpression accelerates growth of tumor cells vitro induces neoplastic developing mouse kidney vivo. In both settings,...
The conformation a particular DNA segment assumes depends upon its sequence context and the environment under which it is prepared. To complement our findings with G-rich sequences related to human telomere, we have been investigating pH induced transition from single strand i-motif for telomere C-rich strand. We carried out titrations of (CCCTAA)4 7.0 5.0 at temperatures ranging 15 45 °C 115 mM K+ concentrations 215 25 °C. Circular dichroism (CD) spectra were determined monitor transition....
Sequencing introns in cancer predisposition genes detects novel loss-of-function variants.
Abstract Mutations in microRNA processing genes such as DROSHA and DICER1 consist of 1.5-2% pediatric cancers including a brain tumor called pineoblastoma. We developed genetically engineered mouse model Drosha- Dicer1- driven pineal tumors. These tumors develop without microRNAs express early developmental markers. Gene set enrichment analysis revealed E2F target to be highly expressed these One the most upregulated is cyclin D2 (Ccnd2). Additionally, stain positively for Rb...