A5013313696- Child Nutrition and Feeding Issues
- Gastrointestinal motility and disorders
- Immunodeficiency and Autoimmune Disorders
- Child and Adolescent Health
- Childhood Cancer Survivors' Quality of Life
- Infant Health and Development
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Renal and related cancers
- Celiac Disease Research and Management
- Acute Lymphoblastic Leukemia research
- Gastroesophageal reflux and treatments
- Food Allergy and Anaphylaxis Research
- Genetic Syndromes and Imprinting
- Eosinophilic Disorders and Syndromes
- Peripheral Neuropathies and Disorders
- Cerebral Palsy and Movement Disorders
- Blood disorders and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Pediatric Pain Management Techniques
- Cannabis and Cannabinoid Research
- Hip disorders and treatments
- Forensic Toxicology and Drug Analysis
- Health, psychology, and well-being
- Nuclear Structure and Function
National Institute of Allergy and Infectious Diseases
2020-2024
National Institutes of Health
2019-2024
The University of Texas Southwestern Medical Center
2016-2018
Children's Medical Center
2017
Boston Children's Hospital
2013-2015
Boston Children's Museum
2014
Dana-Farber Cancer Institute
2014
Harvard University
2013-2014
Universidad del Valle
2011-2013
Functional gastrointestinal disorders (FGIDs) are common in children. Abdominal pain (AP) is the most (GI) symptom The severity of AP drives medical consultations and quality life adult patients with irritable bowel syndrome (IBS). Thirty-eight percent 8- to 15-year-old schoolchildren report weekly 24% those children reporting persistence >8 weeks. Despite high prevalence AP, only 2% school seek attention for AP. Lack parental knowledge on their child's symptoms may constitute one factors...
Synthetic cannabinoid (SC) or "spice" refers to a variety of herbal/chemical mixtures, which mimic the effects marijuana. They are generally marked as "herbal incense" and best known by brand names "K2," "spice," "aroma," "Mr. Nice Guy" "dream." Little data available on psychopathological physical SC.We reported 23-year-old man without prior psychiatric history who developed acute psychosis severe rhabdomyolysis (creatine phosphokinase [CPK]: 44,300 UI/L) associated with consumption. To our...
Many childhood Wilms tumors are driven by mutations in the microRNA biogenesis machinery, but mechanism which these drive tumorigenesis is unknown. Here we show that transcription factor pleomorphic adenoma gene 1 (PLAG1 ) a target overexpressed with processing genes. can also overexpress PLAG1 through copy number alterations, and expression correlates prognosis tumors. overexpression accelerates growth of tumor cells vitro induces neoplastic developing mouse kidney vivo. In both settings,...
Background Treatment‐related mortality and abandonment of therapy are major barriers to successful treatment childhood acute lymphoblastic leukemia (ALL) in the developing world. Procedure A collaboration was undertaken between Instituto Nacional de Cancerologia (Bogota, Colombia), which serves a poor patient population an upper‐middle income country, Dana‐Farber/Boston Children's Cancer Blood Disorders Center (Boston, USA). Several interventions aimed at reducing toxic deaths were...
ABSTRACT Objectives: Functional gastrointestinal disorders (FGIDs) are common. The diagnosis of FGIDs is based on the Rome criteria, a symptom‐based diagnostic classification established by expert consensus. There little evidence validity for pediatric III criteria. construct an overarching term that incorporates other forms validity, has never been assessed. We assessed Methods: Children from 2 schools in Colombia completed Questionnaire Pediatric Gastrointestinal Symptoms at baseline and...
Summary GATA2 deficiency was described in 2011, and shortly thereafter allogeneic hematopoietic stem cell transplantation (HSCT) shown to reverse the hematologic disease phenotype. However, there remain major unanswered questions regarding type of conditioning regimen, donors, graft‐versus‐host (GVHD) prophylaxis. We report 59 patients with mutations undergoing HSCT at National Institutes Health between 2013 2020. Primary endpoints were engraftment, clinical phenotype, secondary overall...
Oral iron chelators and magnetic resonance imaging (MRI) assessment of heart liver burden have become widely available since the mid 2000s, allowing for improved patient compliance with chelation noninvasive monitoring levels titration therapy. We evaluated impact these changes in our center patients thalassemia major transfusional overload. This single center, retrospective observational study covered period from 2005 through 2012. Liver content (LIC) was estimated both by a T2* method R2...
The Bristol Stool Form Scale (BSFS) and a modified child-friendly version (M-BSFS) are frequently used in clinical practice research. These scales have not been validated children. 3-D stool scale models may be better adapted to the child's development.To assess usefulness of BSFS, M-BSFS, newly developed children.Fifty children were asked rank picture cards BSFS from hardest softest match pictures with descriptors for each type.Thirty percent appropriately characterized stools as hard,...
The aim of the study was to establish prevalence abdominal pain (AP) in school children Pasto (Colombia) and determine effect AP on their daily activities; compare other gastrointestinal symptoms between from Chicago.Fourth- fifth-grade students a public private Colombia were invited participate prospective using same methods questionnaires (Spanish version) as previous conducted Chicago schools. Children completed weekly confidential surveys for 8 consecutive weeks.A total 332 participated...
Leukemia and lymphomas are the 2 most frequent malignancies among children in Cali, Colombia, although survival information for these remains limited both Cali throughout all of Colombia.To estimate 5-year rate diagnosed with leukemia University Hospital Valle, at Colombia.Three hundred twenty-four patients younger than 15 years age were included, either or from 1998 to 2006. Active follow-up was conducted by clinical records reviewing phone contacting. The cumulative estimated be 1 5...
Thymoma presents with several autoimmune manifestations and is associated secondary regulator (AIRE) deficiency. Pneumonitis has recently been described as an manifestation thymoma presenting similar clinical, radiographic, histological, autoantibody features seen in patients inherited AIRE deficiency who suffer from Autoimmune PolyEndocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED) syndrome.