A5072353973- Childhood Cancer Survivors' Quality of Life
- Palliative Care and End-of-Life Issues
- Acute Lymphoblastic Leukemia research
- Adolescent and Pediatric Healthcare
- Cancer survivorship and care
- Family Support in Illness
- Clinical practice guidelines implementation
- Cancer Genomics and Diagnostics
- Neutropenia and Cancer Infections
- Health Systems, Economic Evaluations, Quality of Life
- Pediatric Pain Management Techniques
- Cervical Cancer and HPV Research
- Neuroblastoma Research and Treatments
- Ethics and Legal Issues in Pediatric Healthcare
- Health Policy Implementation Science
- Public Health in Brazil
- Cancer-related cognitive impairment studies
- Global Cancer Incidence and Screening
- Reproductive Biology and Fertility
- Nausea and vomiting management
- Health Sciences Research and Education
- Ethics in Clinical Research
- Parvovirus B19 Infection Studies
- Advances in Oncology and Radiotherapy
- Chronic Disease Management Strategies
The University of Texas Health Science Center at San Antonio
2012-2024
The University of Texas Health Science Center at Houston
2019-2024
Children's Cancer Center
2022-2024
The University of Texas at San Antonio
2019-2023
Mays Cancer Center at UT Health San Antonio
2023
Palmetto Hematology Oncology
2016
Cancer Research Institute of the Slovak Academy of Sciences
2016
Individuals diagnosed with cancer between 15 and 39 years (adolescent young adult [AYA]) face unique vulnerability. Detail is lacking about care delivery for these patients, especially those ALL. We address knowledge gaps by describing AYA ALL details at National Cancer Institute Community Oncology Research Program (NCORP) (sub)affiliates model of care.
Clinical practice guideline (CPG)-consistent care improves patient outcomes, but CPG implementation is poor. Little known about in pediatric oncology. This study aimed to understand supportive facilitators and barriers at oncology National Cancer Institute (NCI) Community Oncology Research Program (NCORP) institutions.Healthcare professionals 26 pediatric, Children's Group-member, NCORP institutions were invited participate face-to-face focus groups. Serial groups held until saturation of...
Abstract The objective of the Cancer Control and Supportive Care (CCL) Committee in Children's Oncology Group (COG) is to reduce overall morbidity mortality therapy‐related toxicities children, adolescents, young adults with cancer. We have targeted five major domains that cause clinically important toxicity: (i) infections inflammation; (ii) malnutrition metabolic dysfunction; (iii) chemotherapy‐induced nausea vomiting; (iv) neuro‐ oto‐toxicty; (v) patient‐reported outcomes health‐related...
Adolescents and young adults (AYAs, 15-39 years) with cancer experience disparities in care outcomes compared older/younger patients. AYAs receive from medical pediatric oncologists, however, little is known about the extent of training fellows receive. This needs assessment evaluating current AYA oncology (AYA-O) education fellowship programs to identify knowledge gaps for curricular development.
Abstract Subcutaneous patient-derived xenografts (PDXs) are an important tool for childhood cancer research. Here, we describe a resource of 68 early passage PDXs established from 65 pediatric solid tumor patients. Through genomic profiling paired and patient tumors (PTs), observe low mutational similarity in about 30% the PT/PDX pairs. Clonal analysis these pairs show aggressive PT minor subclone seeds major clone PDX. We evidence that this is more immunogenic likely suppressed by immune...
PURPOSE Database linkage between cancer registries and clinical trial consortia has the potential to elucidate referral patterns of children adolescents with newly diagnosed cancer, including enrollment into trials. This study's primary objective was assess feasibility this approach. METHODS Patients younger than 20 years incident during 2012-2017 in Kentucky Cancer Registry (KCR) were linked patients enrolled a Children's Oncology Group (COG) study. Matched databases described by sex, age,...
There is substantial heterogeneity in symptom management provided to pediatric patients with cancer. The primary objective was describe the adaptation process and specific decisions related care pathways based on clinical practice guidelines. secondary evaluated if institutional factors were associated decisions.
Over the past few decades, 5-year cancer survival has steadily improved for all adolescents and young adults (AYA, 15-39 years at diagnosis) combined. While encouraging, this progress simultaneously highlights a compelling need improving in higher risk AYA subsets addressing health outcomes health-related quality of life (HRQoL) among long-term survivors. The Children's Oncology Group (COG), collaboration with National Cancer Institute (NCI) adult network groups within NCI Clinical Trials...
Patient-derived xenografts (PDX) remain valuable models for understanding the biology and developing novel therapeutics. To expand current PDX of childhood leukemia, we have developed new from Hispanic patients, a subgroup with poorer overall outcome. Of 117 primary leukemia samples obtained, successful engraftment serial passage in mice were achieved 82 (70%). patient engrafted at rate (51/73, 70%) that was similar to non-Hispanic (31/45, 70%). With algorithm remove mouse contamination...
Abstract Background The primary objective was to measure the proportion of episodes where care delivery inconsistent with selected recommendations a clinical practice guideline (CPG) on fever and neutropenia (FN) management. influence site size CPG‐inconsistent delivery, association between patient outcomes were described. Methods This retrospective, multicenter study included patients less than 21 years old cancer who at high risk poor FN previously enrolled Children's Oncology Group (COG)...
Abstract Background This study aimed to determine the proportion of patients receiving clinical practice guideline (CPG)‐inconsistent care related chemotherapy‐induced vomiting (CIV) prophylaxis, and describe association between CPG‐inconsistent site size. The delivery patient outcomes (CIV control, admission prolongation, unplanned healthcare visits) was also described. Methods a retrospective conducted at Children's Oncology Group (COG) National Cancer Institute Community Research Program...
Few studies have explored interventions to improve adolescent and young adult (AYA) cancer care delivery. While many AYAs receive at NCI Community Oncology Research Program (NCORP) sites, few enroll on clinical trials. Barriers facilitators pediatric oncologist activation of enrollment an AYA cross-network National Clinical Trials Network (NCTN) supportive trial were assessed using a survey that was administered 162 stakeholders representing all 47 children's oncology group (COG)...
Abstract Background Objectives were to describe barriers pediatric cancer symptom management care pathway implementation and the impact of COVID-19 pandemic on clinical research evaluating their implementation. Methods We included 25 oncology hospitals in United States that supported a grant submission perform cluster randomized trial which intervention encompassed pathways for management. A survey was distributed site principal investigators prior randomization measure contextual elements...
Purpose: Adolescent and young adult cancer survivors (AYAs) experience early-onset chronic conditions disrupted psychosocial development. We report prevalence of disruptions in care delivery social support during the early wave pandemic a national sample AYAs United States. Materials Methods: used data from population-based National Health Interview Survey (NHIS; July-December 2020), which allows for nationally representative estimates, included questions related to COVID-19. identified 61...
Purpose: The Adolescent and Young Adult (AYA) gap describes the drop-off in survivorship improvement among 15-39-year-olds compared with patients cancer under 15 or over 39. A large body of literature explores why this population experiences lower rates trial enrollment, an issue particular importance since single factor is thought to have greatest impact on decrease survivorship. purpose research primarily identify whether not AYA within a academic center who were treated by pediatric...
Objectives Symptom screening is important to achieving symptom control. Screening in Paediatrics Tool (SSPedi) validated for English-speaking children. were translate SSPedi into Spanish, and evaluate the understandability cultural relevance of translated version among Spanish-speaking children with cancer paediatric haematopoietic stem cell transplant recipients. Methods We conducted a multiphase, descriptive study Spanish. The first step was determine whether one Spanish would be...
The primary objective was to measure adherence clinical practice guideline (CPG) recommendations for fertility preservation (FP) in pediatric cancer patients treated National Cancer Institute Community Oncology Research Program (NCORP) sites. Secondary objectives were describe factors such as site size associated with CPG-inconsistent care delivery and cryopreservation completion.