A5017960939- Neurofibromatosis and Schwannoma Cases
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Nerve injury and regeneration
- Acute Lymphoblastic Leukemia research
- Sarcoma Diagnosis and Treatment
- Signaling Pathways in Disease
- Childhood Cancer Survivors' Quality of Life
- Cancer Genomics and Diagnostics
- Melanoma and MAPK Pathways
- Acute Myeloid Leukemia Research
- 14-3-3 protein interactions
- Axon Guidance and Neuronal Signaling
- CAR-T cell therapy research
- Cellular Mechanics and Interactions
- Ubiquitin and proteasome pathways
- Protein Kinase Regulation and GTPase Signaling
- Renal and related cancers
- Testicular diseases and treatments
- Management of metastatic bone disease
- Hedgehog Signaling Pathway Studies
- Advances in Oncology and Radiotherapy
- RNA modifications and cancer
University of Minnesota
2025
Mayo Clinic
2025
University of California, Los Angeles
2025
The University of Texas Southwestern Medical Center
2015-2024
Southwestern Medical Center
2010-2024
Children's Medical Center
2010-2023
Harold C. Simmons Comprehensive Cancer Center
2023
Center for Cancer and Blood Disorders
2023
Murdoch Children's Research Institute
2016
Royal Children's Hospital
2016
Abstract Existing natural language processing (NLP) methods to convert free-text clinical notes into structured data often require problem-specific annotations and model training. This study aims evaluate ChatGPT’s capacity extract information from medical efficiently comprehensively. We developed a large (LLM)-based workflow, utilizing systems engineering methodology spiral “prompt engineering” process, leveraging OpenAI’s API for batch querying ChatGPT. evaluated the effectiveness of this...
Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder characterized by increased incidence of benign and malignant tumors neural crest origin. Mutations that activate the protooncogene ras, such as loss Nf1, cooperate with inactivating mutations at p53 tumor suppressor gene during transformation. One hundred percent mice harboring null Nf1 alleles in cis synergize to develop soft tissue sarcomas between 3 7 months age. These exhibit heterozygosity both loci express phenotypic...
The mechanisms underlying neuronal ischemic preconditioning, a phenomenon in which brief episodes of ischemia protect against the lethal effects subsequent periods prolonged ischemia, are poorly understood. Ischemia can be modeled vitro by oxygen-glucose deprivation (OGD). We report here that OGD preconditioning induces p21 ras (Ras) activation an N -methyl- d -aspartate receptor- and NO-dependent, but cGMP-independent, manner. demonstrate Ras activity is necessary sufficient for tolerance...
To assess the efficacy of lovastatin on visuospatial learning and attention for treating cognitive behavioral deficits in children with neurofibromatosis type 1 (NF1).
We sought to investigate clinical outcomes of relapsed medulloblastoma and compare molecular features between patient-matched diagnostic tumors.Children infants enrolled on either SJMB03 (NCT00085202) or SJYC07 (NCT00602667) trials who experienced relapse were analyzed for outcomes, including anatomic temporal patterns postrelapse survival. A largely independent, paired cohort was by DNA methylation array next-generation sequencing.A total 72 329 (22%) 52 79 (66%) patients with significant...
Pharmacologic therapies for neurofibromatosis type 1-associated plexiform neurofibromas (NF1-PNs) are limited; currently, none US Food and Drug Administration-approved adults.
Nerve growth factor (NGF) is a required differentiation and survival for sympathetic majority of neural crest-derived sensory neurons in the developing vertebrate peripheral nervous system. Although much known about function NGF, intracellular signaling cascade that it uses continues to be subject intense study. p21 ras considered necessary neuron survival. How additional intermediates downstream or parallel may has not been fully understood yet. Two cascades, extra cellular regulated kinase...
<h3>BACKGROUND AND PURPOSE:</h3> Pleomorphic xanthoastrocytomas are rare astrocytic neoplasms of childhood and young adulthood. The purpose this retrospective review was to evaluate MR imaging features pediatric pleomorphic with an emphasis on diffusion imaging. <h3>MATERIALS METHODS:</h3> Review the neuro-oncology data base revealed 11 patients (range, 4.7–16.1 years) xanthoastroacytomas 9 these having preoperative available. Six had Demographics, histopathology slides, conventional...
TrkA, the high affinity receptor for nerve growth factor (NGF), is essential development of nociceptive sensory and sympathetic neurons. The zinc finger transcription Klf7 interacts with an important cis element TrkA minimal enhancer coexpressed in these We show that binds to endogenous can activate from a sequence-dependent manner. In -/- newborn mice, we find significant reduction neurons due increased apoptosis. neuronal loss restricted normally depend on neurotrophic support, while other...
Objective: We examined the contribution of attention and executive cognitive processes to ADHD symptomatology in NF1, as well relationships between cognition symptoms with functional outcomes. Methods: The study sample consisted 141 children adolescents NF1. Children were administered neuropsychological tests that assessed function, from which latent variables derived. symptomatology, adaptive skills, quality life (QoL) using parent-rated questionnaires. Path analyses conducted test among...
Abstract Objective Rapid developments in understanding the molecular mechanisms underlying cognitive deficits neurodevelopmental disorders have increased expectations for targeted, mechanism‐based treatments. However, translation from preclinical models to human clinical trials has proven challenging. Poor reproducibility of endpoints may provide one explanation this finding. We examined suitability outcomes children with neurofibromatosis type 1 (NF1) by examining test‐retest reliability...
Peripheral ganglion neurons confer sensory information including touch, pain, temperature, and proprioception. Sensory modality is linked to specific neurotrophin (NTF) requirements. NT-3 supports survival of that differentiate primarily into proprioceptors whereas nerve growth factor brain-derived neurotrophic (BDNF) support subpopulations transmit nociception mechanoreception, respectively. We examined gene-targeted mouse mutants at the NT-4, BDNF, NT-3, TrkA loci. show NT-4 functions...
This report presents a series of 5 pediatric patients with disseminated pilocytic astrocytomas and frequent nonfusion activating mutations. Genetic variants in these patients' tumors include BRAF p.Val600Glu, p.Val600Asp, KRAS p.Gly60_Gln62ins7. The 2 BRAF-mutated were treated dabrafenib or combination plus trametinib. had either near complete resolution the primary tumor (BRAF p.Val600Glu) stable p.Val600Asp). Both showed improvement leptomeningeal dissemination without significant...
We report a male infant with L-2-hydroxyglutaric aciduria and Wilms tumor. is rare, autosomal-recessive, inborn error of metabolism characterized by variable degree progressive encephalopathy. Of the fewer than 100 cases reported in literature, at least 9 patients have developed tumors central nervous system. To our knowledge, present case 1st example an extracranial tumor associated aciduria. This observation potentially widens spectrum this metabolic disorder may lead to further insight...