A5018051211- Thyroid Disorders and Treatments
- Anatomy and Medical Technology
- Cardiovascular Function and Risk Factors
- Iron Metabolism and Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Erythrocyte Function and Pathophysiology
- Surgical Simulation and Training
- Sarcoidosis and Beryllium Toxicity Research
- Hemoglobinopathies and Related Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Cystic Fibrosis Research Advances
- Legionella and Acanthamoeba research
- Gallbladder and Bile Duct Disorders
- Vascular Malformations Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Glioma Diagnosis and Treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hormonal Regulation and Hypertension
- Neurofibromatosis and Schwannoma Cases
- Liver Disease Diagnosis and Treatment
- Blood disorders and treatments
- Digital Imaging in Medicine
- Genetic and Kidney Cyst Diseases
- IgG4-Related and Inflammatory Diseases
- Vasculitis and related conditions
British Columbia Children's Hospital
2020-2024
University of British Columbia
2022
Boston Children's Hospital
2020
The University of Texas Southwestern Medical Center
2018
University of Ottawa
2013
This report presents a series of 5 pediatric patients with disseminated pilocytic astrocytomas and frequent nonfusion activating mutations. Genetic variants in these patients' tumors include BRAF p.Val600Glu, p.Val600Asp, KRAS p.Gly60_Gln62ins7. The 2 BRAF-mutated were treated dabrafenib or combination plus trametinib. had either near complete resolution the primary tumor (BRAF p.Val600Glu) stable p.Val600Asp). Both showed improvement leptomeningeal dissemination without significant...
Central mechanisms involving mineralocorticoid receptor (MR) activation contribute to an increase in sympathetic tone after myocardial infarction (MI). We hypothesized that this central mechanism also contributes cardiac axonal sprouting and MR blockade reduces hyperinnervation post-MI. Post-MI, tyrosine hydroxylase (TH) norepinephrine transporter protein content the noninfarcted base of heart remained unaltered. In contrast, gene product (PGP)9.5 was increased twofold sixfold peri-infarct...
Granulomatosis with polyangiitis is rare in children. We report a case of 12-year-old male who presented new symptoms left eyelid swelling and ptosis. Magnetic resonance imaging showed an enhancing orbital mass suspicious for neoplasm. Excisional biopsy was performed. Microscopic examination revealed fibrovascular tissue dense collagenous fibrosis mixed inflammatory infiltrate that included many plasma cells. Many small medium-sized blood vessels granulomatous necrotizing vasculitis...
Context.— Smart glasses are a wearable technology that enable hands-free data acquisition and entry. Objective.— To develop surgical pathology grossing application on smart glass platform. Design.— An existing logistics software for the Google Glass Enterprise platform was used to create protocols. The 2 protocols were developed simulate complex (heart) simple (kidney) specimen. For both protocols, users visually prompted by device perform each task, record measurements, or document field of...
In the clinical classification of cholelithiasis, biliary sludge (BS) is distinguished as pre-stone stage. Ursodeoxycholic acid (UDCA) a drug with an evidence base for effective and safe effects on BS. The therapeutic equivalence various UDCA drugs remains important issue practice. Aim. To conduct comparative analysis effectiveness use UDCA: Ursofalk other treatment BS in fixed dose 10 mg/kg body weight. Material methods. observation group consisted 225 patients types randomized groups,...
Graves' disease (GD) is rare in children under age five years. Antithyroid drugs are typically first-line therapy but carry the risks of agranulocytosis and liver dysfunction. A male infant with multiple congenital anomalies, left ventricular hypertrophy, neurologic dysfunction developed GD at months life. The presence chronic hepatitis complicated medical management. Potassium iodide was effective temporarily, urgent thyroidectomy required nine age. Postoperatively, patient a thyroid...
Only a few case reports in the pediatric population describe sickle cell trait (SCT)-associated deaths. We report fatal of acute splenic sequestration crisis an infant with SCT and discuss postmortem diagnostic challenges associated this condition. The deceased is 4-month-old black boy history prematurity (delivered at 34 weeks) low birth weight (1.93 kg). family was observed by child protective services. According to caretaker, placed sleep same bed his parents another child. Several hours...
Abstract Recently, the rates of contralateral prophylactic mastectomy (CPM) have increased significantly with no clear evidence improvement in overall survival or breast cancer (BC) specific survival. In 2016, American Society Breast Surgeons (ASBS) provided a consensus statement regarding when CPM should be-, can be- may be offered and it discouraged. light new recommendations, our study aimed to review factors that influenced choice at institution. Methods: This retrospective was approved...