A5088385871- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Fetal and Pediatric Neurological Disorders
- Childhood Cancer Survivors' Quality of Life
- Neuroblastoma Research and Treatments
- Vascular Malformations Diagnosis and Treatment
- Testicular diseases and treatments
- Chromatin Remodeling and Cancer
- Acute Lymphoblastic Leukemia research
- Neurofibromatosis and Schwannoma Cases
- Cerebrospinal fluid and hydrocephalus
- Glutathione Transferases and Polymorphisms
- Scoliosis diagnosis and treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Histone Deacetylase Inhibitors Research
- HER2/EGFR in Cancer Research
- Boron Compounds in Chemistry
- Adrenal and Paraganglionic Tumors
- Soft tissue tumor case studies
- Management of metastatic bone disease
- Effects of Radiation Exposure
- Neuroinflammation and Neurodegeneration Mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Neuroscience and Neuropharmacology Research
Children's Medical Center
2007-2020
The University of Texas Southwestern Medical Center
2003-2018
Neurological Surgery
2016
Southwestern Medical Center
2013
Dartmouth College
2013
Dartmouth Hospital
2013
Université de Lorraine
2012
Center for Cancer and Blood Disorders
2010
European School of Oncology
2009
The purpose of our study was to compare the imaging characteristics atypical teratoid-rhabdoid tumor with medulloblastoma and seek distinguishing features that can aid in preoperative diagnosis.Preoperative MRI examinations 55 patients (36 medulloblastomas 19 tumors) were analyzed retrospectively. Imaging assessed conventional CT. Diffusion-weighted (DWI) available 27 (19 eight tumors). Apparent diffusion coefficient (ADC) values calculated for 14 six tumors.Both tumors general...
The pilocytic astrocytoma (PA) is the most common childhood brain tumor. This report examines MIB-1 labeling index (LI) as a predictor of progression-free survival (PFS) among PAs.Consecutive PAs were examined to determine whether LI was associated with tumor progression. Other variables evaluated included location, use adjuvant therapy, extent resection, and age at diagnosis.One hundred forty-one children identified (mean +/- SD age, 7.6 4.7 years; range, 0.43 18.56 years); 118 had adequate...
<h3>BACKGROUND AND PURPOSE:</h3> Pleomorphic xanthoastrocytomas are rare astrocytic neoplasms of childhood and young adulthood. The purpose this retrospective review was to evaluate MR imaging features pediatric pleomorphic with an emphasis on diffusion imaging. <h3>MATERIALS METHODS:</h3> Review the neuro-oncology data base revealed 11 patients (range, 4.7–16.1 years) xanthoastroacytomas 9 these having preoperative available. Six had Demographics, histopathology slides, conventional...
This report presents a series of 5 pediatric patients with disseminated pilocytic astrocytomas and frequent nonfusion activating mutations. Genetic variants in these patients' tumors include BRAF p.Val600Glu, p.Val600Asp, KRAS p.Gly60_Gln62ins7. The 2 BRAF-mutated were treated dabrafenib or combination plus trametinib. had either near complete resolution the primary tumor (BRAF p.Val600Glu) stable p.Val600Asp). Both showed improvement leptomeningeal dissemination without significant...
Object The object of this study was to identify prognostic factors for survival among children with recurrent medulloblastoma. Methods Postprogression and patient, tumor, treatment were examined in 46 cases medulloblastoma (mean age patients at diagnosis 6.5 years, mean progression 8.4 years). Differences calculated by Kaplan–Meier log-rank analysis. Multivariate analysis performed using the Cox proportional hazard model. Results probability 5-year 26.3%. Forty-one received salvage therapy...
Few reports describe the outcome and prognostic factors for children with gangliogliomas. The objective of this report was to progression-free survival (PFS) low-grade gangliogliomas identify risk tumor progression.A retrospective study performed in who were evaluated treated neuro-oncology department between 1986 2006 determine subsequent total 38 newly diagnosed included report. Thirty-four surgery alone, 3 subtotal resection radiation therapy, 1 chemotherapy. follow-up ranged from 4...
Abstract Introduction Despite recognition that childhood brain tumor survivors often suffer multiple late effects following therapy, little is known regarding the long‐term follow‐up (LTFU) programs for these patients. Methods A 16‐question survey was mailed to member institutions of Children's Oncology Group in United States. Institutions were asked about size their program, activities LTFU and perceived barriers follow‐up. Results One hundred forty‐five (74%) 197 returned surveys. Care...
Survivors of childhood brain tumors may be at risk for early onset metabolic syndrome, possibly secondary to surgery and/or radiation exposure. This study examines effects exposure hypothalamus-pituitary-adrenal axis (HPA) on among survivors tumors. One hundred forty-two met inclusion criteria; 60 had tumor plus (>1 Gray (Gy)) HPA. The second subgroup 82 subjects only and were not exposed radiation. Both subgroups survived approximately 5 years the time study. All clinical evaluation, vital...
<h3>BACKGROUND AND PURPOSE:</h3> Although utility of diffusion MR imaging in the preoperative diagnosis common pediatric cerebellar tumors is generally recognized, its added value has not been systematically studied previously. The purpose this study was to evaluate impact on accuracy among reviewers with different experience levels. <h3>MATERIALS METHODS:</h3> Review neuro-oncology data base yielded 96 patients whose brain included both (<i>b</i> = 1000 s/mm<sup>2</sup>) and ADC maps. There...
Although pilocytic astrocytoma (PA) is the most common brain tumor diagnosed in children, few prognostic variables have been delineated that stratify risk of clinical progression patients with this tumor. In study, MIB-1 labeling index was compared 2 other immunohistochemical markers cell proliferation, phospho-histone H3 (PHH3) and mini-chromosomal maintenance protein (MCM2) 80 incompletely resected PAs to see which best able identify at for progression. 0(6)-Methylguanine-DNA...
Background: The objectives of this study are to determine the prevalence and relative risk (RR) back pain identify possible mechanisms among childhood acute lymphoblastic leukemia (ALL) survivors. Methods: Surveys were mailed 5+-year survivors ALL aged 13 25 years. Survivors’ siblings also invited participate in study. Prevalence hip was determined compared with siblings. Sex, treatment radiation therapy, obesity, physical activity examined for an association pain. Results: Forty-four 99...
Different tectal masses have been described; most are low-grade gliomas. Only 20-30% of all lesions grow, as shown on follow-up MRIs, requiring surgical resection at some point. The aim this study is to describe the experience a single institution managing pediatric patients with lesions.We retrospectively studied and analyzed 40 children managed from 1990 2006; mean age diagnosis was 9.4 years. A volumetric classification used analyze tumor growth trends. More than 1 year imaging available...
9562 Background: The objective of this study is to determine the prevalence and relative risk (RR) back pain hip among childhood leukemia survivors identify possible factors for acute lymphoblastic (ALL) survivors. Methods: Surveys were mailed 5+ year ALL aged 13 – 25 years. Survivors’ siblings also invited participate in serve as a comparison group. Prevalence was determined compared with sibling cohort. Gender, obesity, physical activity, treatment radiation therapy examined association...
1556 Background: Despite improvement in therapies, a substantial number of children with medulloblastoma experience tumor progression. The objectives this single institution report are to the 5 year post-progression survival and identify prognostic factors for among progressive or recurrent medulloblastoma. Methods: relationship between demographic, tumor, treatment were examined 46 patients (22 females; mean age at diagnosis = 6.5 years; progression 8.4 years) Differences calculated by...