A5063227349- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Dysraphism and Malformations
- Fetal and Pediatric Neurological Disorders
- Meningioma and schwannoma management
- Neonatal and fetal brain pathology
- Neuroblastoma Research and Treatments
- Head and Neck Surgical Oncology
- Neurofibromatosis and Schwannoma Cases
- Epilepsy research and treatment
- Craniofacial Disorders and Treatments
- Neonatal Respiratory Health Research
- Cleft Lip and Palate Research
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury Research
- Medical Imaging Techniques and Applications
- Anesthesia and Neurotoxicity Research
- Advanced Neuroimaging Techniques and Applications
- Pharmacological Effects and Toxicity Studies
- Neurosurgical Procedures and Complications
- Facial Trauma and Fracture Management
- Cancer Genomics and Diagnostics
- Optical Imaging and Spectroscopy Techniques
- Advanced MRI Techniques and Applications
Humboldt-Universität zu Berlin
2006-2025
Charité - Universitätsmedizin Berlin
2016-2025
Freie Universität Berlin
2018-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2020
Pediatrics and Genetics
2010-2014
Object Neonatal intraventricular hemorrhage (IVH) may evolve into posthemorrhagic hydrocephalus and cause neurodevelopmental impairment. In this study, an endoscopic surgical approach directed toward the removal of hematoma was evaluated for its safety efficacy. Methods Between August 2010 December 2012 (29 months), 19 neonates with underwent neuro lavage blood remnants. During a similar length time months) from March 2008 to July 2010, 10 were treated conventionally, initially using...
Epilepsy affects 50 million people worldwide and is drug-resistant in approximately one-third of cases. Even when a structural lesion identified as the epileptogenic focus, understanding underlying genetic causes crucial to guide both counseling treatment decisions. Both somatic germline DNA variants may contribute itself and/or influence severity symptoms. We therefore used whole exome sequencing (WES) search for potentially pathogenic brain samples from children with lesional epilepsy who...
Abstract Pineal region tumors commonly present with non-communicating hydrocephalus. These heterogeneous histological entities require different therapeutic regimens. We evaluated our surgical experience concerning procurance of a diagnosis, management hydrocephalus, and choice antitumoral treatment. analyzed the efficacy neuroendoscopic biopsy endoscopic third ventriculocisternostomy (ETV) in patients pineal between 2006 2019 single-center retrospective cross-sectional study regard to...
Although epilepsy surgery is the only curative therapeutic approach for lesional drug-resistant (DRE), there reluctance to operate on infants due a fear of complications. A recent meta-analysis showed that in first 6 months life can achieve seizure control about two thirds children. However, robust data surgical complications and postoperative cognitive development are lacking. We performed retrospective multicenter study who underwent life. 15 at median age 134 days (IQR: 58) four centers....
Multiloculated hydrocephalus remains a challenging condition to treat in the pediatric hydrocephalic population. In retrospective study, authors reviewed their experience with navigated endoscopy multiloculated children.Between April 2004 and September 2008, endoscopic procedures were performed 16 children (median age 8 months, mean 16.1 +/- 23.3 months). all patients preoperative MR imaging was used for planning entry sites trajectories of approach cyst perforation catheter positioning....
Abstract Genetic variants in relevant genes coexisting with MRI lesions children drug‐resistant epilepsy (DRE) can negatively influence surgery outcomes. Still, presurgical evaluation does not include genetic diagnostics routinely. Here, we report our algorithm that includes routine testing. We analyzed retrospectively the data of 68 DRE operated at a mean age 7.8 years (IQR: 8.1 years) center. In 49 children, test results were available. identified 21 gene (ACMG III: n = 7, ACMG IV: 2, V:...
ObjectiveThis study validated VParNet and nnU-Net for ventricular segmentation in pediatric hydrocephalus, a condition characterized by irregular asymmetric shapes. MethodsManual of 139 MRI scans (ages range 2.6 -20.3 years) was performed the four ventricles aqueduct. A five-fold cross-validation conducted both models. tested with its original weights after retraining on data. extended to also segment Performance evaluated using Dice Similarity Coefficient (DSC), Intraclass Correlation...
Object. Although it is generally acknowledged that a sufficient cerebral perfusion pressure (CPP) necessary for treatment of severe head injury, the optimum CPP still subject debate. The purpose this study was to investigate effect various levels blood and, thereby, on posttraumatic contusion volume. Methods. left hemispheres 60 rats were subjected controlled cortical impact injury (CCII). In one group animals mean arterial (MABP) lowered 30 minutes 80, 70, 60, 50, or 40 mm Hg 4 hours after...
Significance, origin and nature of posttraumatic brain edema are still being debated. Recently, a "controlled cortical impact injury" (CCII) was introduced to model traumatic injury. Purpose this study investigate the development following CCII. Traumatic injury applied intact dura left hemisphere in Sprague-Dawley rats (n = 52, 250–350 g b.w.). Ketamine/xylazine-anesthesia or inhalation-anesthesia were used. A pneumatic impactor with diameter 5 mm contused temporo-parietal cortex velocity 7...
A standardized guideline for treatment of posthemorrhagic hydrocephalus in premature infants is still missing. Because an early ventriculoperitoneal shunt surgery avoided due to low body weight and fragility the patients, neurosurgical focuses on temporary solutions CSF diversion as a minimally invasive approach. Neuroendoscopic lavage (NEL) was additionally introduced elimination intraventricular blood components reduce possible subsequent complications such dependency, infection,...
First-line treatment of pediatric low-grade glioma using surgery, radio- or chemotherapy fails in a relevant proportion patients. We analyzed efficacy subsequent surgical and nonsurgical therapies the German cohort SIOP-LGG 2004 study (2004-2012, 1558 registered patients; median age at diagnosis 7.6 years, observation time 9.2 overall survival 98%/96% 5/10 15% neurofibromatosis type 1 [NF1]). During follow-up, 1078/1558 patients remained observed without (n = 217), with 707), 2 124) 3 to 6...
Abstract Background Although cavitating ultrasonic aspirators are commonly used in neurosurgical procedures, the suitability of aspirator-derived tumor material for diagnostic procedures is still controversial. Here, we explore feasibility using aspirator-resected tissue to classify otherwise discarded sample by fast DNA methylation-based analysis low pass nanopore whole genome sequencing. Methods Ultrasonic specimens from pediatric patients undergoing brain resection were subjected low-pass...
Objectives Reduction of cerebral perfusion during the early phase after traumatic brain injury is followed by a later normal to increased perfusion. Thus, pharmacologically elevating mean arterial blood pressure with aim improving may exert different time-dependent effects on cortical perfusion, microcirculation, tissue oxygenation and edema formation injury. Design Randomized, placebo-controlled trial. Setting Experimental laboratory at university hospital. Subjects A total 37 male...