A5085532914- Glioma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Epilepsy research and treatment
- Neonatal and fetal brain pathology
- MRI in cancer diagnosis
- Functional Brain Connectivity Studies
- Spinal Dysraphism and Malformations
- Meningioma and schwannoma management
- Nuclear Physics and Applications
- Neurological disorders and treatments
- Advanced NMR Techniques and Applications
- Neuroblastoma Research and Treatments
- Acute Ischemic Stroke Management
- Medical Imaging Techniques and Applications
- Neurogenetic and Muscular Disorders Research
- Radiomics and Machine Learning in Medical Imaging
- Neurofibromatosis and Schwannoma Cases
- EEG and Brain-Computer Interfaces
- Brain Metastases and Treatment
- Head and Neck Surgical Oncology
- scientometrics and bibliometrics research
Charité - Universitätsmedizin Berlin
2016-2025
Humboldt-Universität zu Berlin
1996-2025
Freie Universität Berlin
2018-2025
Royal Children's Hospital
2024
University Hospital Augsburg
2024
Committee on Publication Ethics
2021
Society for Neuroscience
2020-2021
Society for Neuroscience in Anesthesiology and Critical Care
2020-2021
Vrije Universiteit Amsterdam
2021
University Hospital Bonn
2021
Background and Purpose— Treatment options for patients with acute ischemic stroke depend on the volume of salvageable tissue. This assessment is currently based fixed thresholds single imagine modalities, limiting accuracy. We wish to develop validate a predictive model capable automatically identifying combining imaging features accurately predict final lesion volume. Methods— Using magnetic resonance imaging, we developed trained deep convolutional neural network (CNN ) outcome. A total...
See Kreisl (doi:10.1093/awx151) for a scientific commentary on this article.Subjects with mild cognitive impairment associated cortical amyloid-β have greatly increased risk of progressing to Alzheimer's disease. We hypothesized that neuroinflammation occurs early in disease and would be present most amyloid-positive cases. 11C-Pittsburgh compound B 11C-(R)-PK11195 positron emission tomography was used determine the amyloid load detect extent (microglial activation) 42 Twelve age-matched...
Chemical exchange saturation transfer (CEST)-derived, pH-weighted, amide proton (APT) MRI has shown promise in animal studies for the prediction of infarction risk ischemic tissue. Here, APT was translated to patients with acute stroke (1-24 h post-symptom onset), and assessments contrast, perfusion, diffusion, disability final infarct volume (23-92 days post-stroke) are reported. Healthy volunteers (n = 5) 10) onset symptoms (0-4 h, n 7; uncertain <24 3) were scanned diffusion-...
Abstract One outstanding challenge for machine learning in diagnostic biomedical imaging is algorithm interpretability. A key application the identification of subtle epileptogenic focal cortical dysplasias (FCDs) from structural MRI. FCDs are difficult to visualize on MRI but often amenable surgical resection. We aimed develop an open-source, interpretable, surface-based machine-learning automatically identify heterogeneous data epilepsy surgery centres worldwide. The Multi-centre Epilepsy...
Antiangiogenic therapies are being pursued as a means of starving tumors their energy supply. Although numerous studies show that such render hypoxic, just many have, surprisingly, shown improved tumor oxygenation. These contradicting findings challenge both the original rationale for antiangiogenic therapy and our understanding physiology tissue The flow-diffusion equation, which describes relation between blood flow extraction freely diffusible molecules in tissue, was recently extended to...
OBJECTIVE Mutations in the isocitrate dehydrogenase (IDH) genes are of proven diagnostic and prognostic significance for cerebral gliomas. The objective this study was to evaluate clinical feasibility using a recently described method determining IDH mutation status by magnetic resonance spectroscopy (MRS) detect presence 2-hydroxyglutarate (2HG), metabolic product mutant enzyme. METHODS By extending imaging time 6 minutes, authors were able include point-resolved (PRESS) MRS sequence their...
<h3>BACKGROUND AND PURPOSE:</h3> Diffusional kurtosis imaging is an MR technique that provides microstructural information in biologic systems. Its application clinical studies, however, hampered by long acquisition and postprocessing times. We evaluated a new fast (2 minutes 46 seconds) diffusional method with regard to glioma grading, compared it conventional imaging, the diagnostic accuracy of mean (MK′) widely used diffusivity. <h3>MATERIALS METHODS:</h3> MK′ diffusivity were measured...
Abstract Hypoparathyroidism (hypoPT) is characterized by a state of low bone turnover and high mineral density (BMD) despite conventional treatment with calcium supplements active vitamin D analogues. To assess effects PTH substitution therapy on 3-dimensional structure, we randomized 62 patients hypoPT into 24 weeks either PTH(1-84) 100 µg/day subcutaneously or similar placebo as an add-on therapy. Micro-computed tomography was performed 44 iliac crest biopsies (23 treatment) obtained after...
With a growing appreciation for interindividual anatomical variability and patient-specific brain connectivity, advanced imaging sequences offer the opportunity to directly visualize targets deep stimulation (DBS). The lack of quantitative evidence demonstrating their clinical utility, however, has hindered broad implementation in practice.Using fast gray matter acquisition T1 inversion recovery (FGATIR) sequences, present study identified thalamic hypointensity that holds promise as visual...
MRI-based whole-brain manual segmentation methods are considered the gold standard for brain volumetric analysis but time-consuming and prone to human error. Automated tools like FreeSurfer can identify differences in volumes between healthy non-healthy individuals. Deep-learning-based tools, such as FastSurfer, offer faster processing times, further validation is needed, particularly pediatric cases. This study aims validate FastSurfer against a cohort compare volume estimates with...
Abstract Background Patients with mutations in the monocarboxylate transporter 8 (MCT8, SLC16A2 ) suffer from X‐linked recessive Allan‐Herndon‐Dudley syndrome (AHDS), which is characterized by developmental delay and a severe movement disorder. Current trials using thyroid hormone derivatives to overcome defect have failed achieve patient‐oriented therapeutic goals. Objectives Our aim was define type of disorder AHDS an observational cohort study investigate causative role dopaminergic...
Abstract Pineal region tumors commonly present with non-communicating hydrocephalus. These heterogeneous histological entities require different therapeutic regimens. We evaluated our surgical experience concerning procurance of a diagnosis, management hydrocephalus, and choice antitumoral treatment. analyzed the efficacy neuroendoscopic biopsy endoscopic third ventriculocisternostomy (ETV) in patients pineal between 2006 2019 single-center retrospective cross-sectional study regard to...
Although epilepsy surgery is the only curative therapeutic approach for lesional drug-resistant (DRE), there reluctance to operate on infants due a fear of complications. A recent meta-analysis showed that in first 6 months life can achieve seizure control about two thirds children. However, robust data surgical complications and postoperative cognitive development are lacking. We performed retrospective multicenter study who underwent life. 15 at median age 134 days (IQR: 58) four centers....
Abstract Genetic variants in relevant genes coexisting with MRI lesions children drug‐resistant epilepsy (DRE) can negatively influence surgery outcomes. Still, presurgical evaluation does not include genetic diagnostics routinely. Here, we report our algorithm that includes routine testing. We analyzed retrospectively the data of 68 DRE operated at a mean age 7.8 years (IQR: 8.1 years) center. In 49 children, test results were available. identified 21 gene (ACMG III: n = 7, ACMG IV: 2, V:...
Epilepsy affects 50 million people worldwide and is drug-resistant in approximately one-third of cases. Even when a structural lesion identified as the epileptogenic focus, understanding underlying genetic causes crucial to guide both counseling treatment decisions. Both somatic germline DNA variants may contribute itself and/or influence severity symptoms. We therefore used whole exome sequencing (WES) search for potentially pathogenic brain samples from children with lesional epilepsy who...
Importance A leading cause of surgically remediable, drug-resistant focal epilepsy is cortical dysplasia (FCD). FCD challenging to visualize and often considered magnetic resonance imaging (MRI) negative. Existing automated methods for detection are limited by high numbers false-positive predictions, hampering their clinical utility. Objective To evaluate the efficacy interpretability graph neural networks in automatically detecting lesions on MRI scans. Design, Setting, Participants In this...
MRI-based whole-brain manual segmentation methods are considered the gold standard for brain volumetric analysis but time-consuming and prone to human error. Automated tools like FreeSurfer can identify differences in volumes between healthy non-healthy individuals. Deep-learning-based tools, such as FastSurfer, offer faster processing times, further validation is needed, particularly pediatric cases. This study aims validate FastSurfer against a cohort compare volume estimates with...