Martin Mynarek
A5080142988- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Cancer Genomics and Diagnostics
- Brain Metastases and Treatment
- Hedgehog Signaling Pathway Studies
- Cancer, Hypoxia, and Metabolism
- Renal and related cancers
- Ocular Oncology and Treatments
- Chromatin Remodeling and Cancer
- Meningioma and schwannoma management
- Sarcoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Testicular diseases and treatments
- Radiomics and Machine Learning in Medical Imaging
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Neurofibromatosis and Schwannoma Cases
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Cytomegalovirus and herpesvirus research
- Childhood Cancer Survivors' Quality of Life
- Head and Neck Surgical Oncology
- Viral-associated cancers and disorders
- Tumors and Oncological Cases
University Medical Center Hamburg-Eppendorf
2016-2025
Universität Hamburg
2016-2025
University Cancer Center Hamburg
2022-2023
University Hospital Leipzig
2016
University Hospital Heidelberg
2016
Radboud University Nijmegen
2016
Lurie Children's Hospital
2016
University Children's Hospital Zurich
2016
University of Bonn
2016
Heidelberg University
2016
Abstract Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents children. They represent a morphologically heterogeneous class of some entities lack defining histopathological features. Therefore, the diagnosis sarcomas is burdened with high inter-observer variability misclassification rate. Here, we demonstrate classification using machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma trained dataset 1077 profiles from...
Posterior fossa ependymoma comprises two distinct molecular variants termed EPN_PFA and EPN_PFB that have a biology natural history. The therapeutic value of cytoreductive surgery radiation therapy for posterior after accounting subgroup is not known.Four independent nonoverlapping retrospective cohorts ependymomas (n = 820) were profiled using genome-wide methylation arrays. Risk stratification models designed based on known clinical newly described biomarkers identified by multivariable...
The large diversity of central nervous system (CNS) tumor types in children and adolescents results disparate patient outcomes renders accurate diagnosis challenging. In this study, we prospectively integrated DNA methylation profiling targeted gene panel sequencing with blinded neuropathological reference diagnostics for a population-based cohort more than 1,200 newly diagnosed pediatric patients CNS tumors, to assess their utility routine neuropathology. We show that the multi-omic...
Purpose To assess an intensified treatment in the context of clinical and biologic risk factors metastatic medulloblastoma. Patients Methods (4 to 21 years old, diagnosed between 2001 2007) received induction chemotherapy, dose-escalated hyperfractionated craniospinal radiotherapy, maintenance chemotherapy. Subgroup status other parameters were assessed. Results In 123 eligible patients (median age, 8.2 old; median follow-up, 5.38 years), 5-year event-free survival (EFS) overall (OS) 62%...
This study aimed to prospectively evaluate clinical, histopathological and molecular variables for outcome prediction in medulloblastoma patients. Patients from the HIT2000 cooperative clinical trial were enrolled based on availability of sufficient tumor material complete information. revealed a cohort 184 patients (median age 7.6 years), which was randomly split at 2:1 ratio into training (n = 127), test 57) dataset order build risk score this population. Independent validation performed...
The HIT-2000-BIS4 trial aimed to avoid highly detrimental craniospinal irradiation (CSI) in children < 4 years of age with nonmetastatic medulloblastoma by systemic chemotherapy, intraventricular methotrexate, and risk-adapted local radiotherapy.From 2001-2011, 87 patients received chemotherapy methotrexate. Until 2006, CSI was reserved for nonresponse or progression. After radiotherapy introduced nonresponders classic (CMB) large-cell/anaplastic (LCA). DNA methylation profiles infantile...
Abstract Background Molecular brain tumor diagnosis is usually dependent on tissue biopsies or resections. This can pose several risks associated with anesthesia neurosurgery, especially for lesions in the stem other difficult-to-reach anatomical sites. Apart from initial diagnosis, progression, recurrence, acquisition of novel genetic alterations only be proven by re-biopsies. Methods We employed Nanopore sequencing cell-free DNA (cfDNA) cerebrospinal fluid (CSF) and analyzed copy number...
Human adenovirus (HAdV) infection after hematopoietic stem cell transplantation (HSCT) is associated with significant morbidity and mortality in children. The optimal surveillance treatment strategies are under discussion. Here, we present data from 238 consecutive pediatric allogeneic HSCT recipients who underwent a single center were included prospective, weekly HAdV DNAemia monitoring program by quantitative PCR. loads >1000 copies/mL detected 15.5% of all patients. Despite low directly...
PURPOSE The identification of a heritable tumor predisposition often leads to changes in management and increased surveillance individuals who are at risk; however, for many rare entities, our knowledge is incomplete. METHODS Families with childhood medulloblastoma, one the most prevalent malignant brain tumors, were investigated identify predisposing germline mutations. Initial findings extended genomes epigenomes 1,044 medulloblastoma cases from international multicenter cohorts, including...
Abstract Two distinct genetically defined entities of ependymoma arising in the supratentorial compartment are characterized by presence either a C11orf95-RELA or YAP-MAMLD1 fusion, respectively. There is growing evidence that ependymomas without these genetic features exist. In this study, we report on 18 pediatric non- RELA/ YAP were systematically means their histology, immunophenotype, genetics, and epigenomics. Comprehensive molecular analyses included high-resolution copy number...
Abstract Ependymomas encompass multiple clinically relevant tumor types based on localization and molecular profiles. Tumors of the methylation class “spinal ependymoma” (SP-EPN) represent most common intramedullary neoplasms in children adults. However, their developmental origin is ill-defined, data are scarce, potential heterogeneity within SP-EPN remains unexplored. The only known recurrent genetic events loss chromosome 22q NF2 mutations, but neither frequency these alterations nor...
Pineoblastoma is a rare pineal region brain tumor. Treatment strategies have reflected those for other malignant embryonal tumors.Original prospective treatment and outcome data from international trial groups were pooled. Cox regression models developed considering elements as time-dependent covariates.Data on 135 patients with pineoblastoma aged 0.01-20.7 (median 4.9) years analyzed. Median observation time was 7.3 years. Favorable prognostic factors age ≥4 (hazard ratio [HR]...
Abstract Background Myxopapillary ependymoma (MPE) is a heterogeneous disease regarding histopathology and outcome. The underlying molecular biology poorly understood, markers that reliably predict the patients’ clinical course are unknown. Methods We assembled cohort of 185 tumors classified as MPE based on DNA methylation. Methylation patterns, copy number profiles, MGMT promoter methylation were analyzed for all tumors, 106 evaluated histomorphologically, RNA sequencing was performed 37...
Abstract Medulloblastomas (MBs) are malignant pediatric brain tumors that molecularly and clinically heterogenous. The application of omics technologies—mainly studying nucleic acids—has significantly improved MB classification stratification, but treatment options still unsatisfactory. proteome their N-glycans hold the potential to discover relevant phenotypes targetable pathways. We compile a harmonized dataset 167 MBs integrate findings with DNA methylome, transcriptome N-glycome data....