Sandro Casavilca‐Zambrano
A5070349217- Nutrition, Genetics, and Disease
- Glioma Diagnosis and Treatment
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- Cutaneous Melanoma Detection and Management
- RNA modifications and cancer
- Sarcoma Diagnosis and Treatment
- Ocular Oncology and Treatments
- Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Viral-associated cancers and disorders
- Mycotoxins in Agriculture and Food
- Cutaneous lymphoproliferative disorders research
- Molecular Biology Techniques and Applications
- Brain Metastases and Treatment
- Genetic Associations and Epidemiology
- Immunotherapy and Immune Responses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis B Virus Studies
- Pituitary Gland Disorders and Treatments
Instituto Nacional de Enfermedades Neoplásicas
2016-2025
Universidad de Huánuco
2018-2025
International Potato Center
2022-2024
Institut de Recherche pour le Développement
2022
ORCID
2022
University of Iowa
2021
Iowa City Public Library
2021
Indiana University – Purdue University Indianapolis
2021
Indiana University School of Medicine
2021
St. Mary's Medical Center
2021
Central nervous system neoplasms with combined features of malignant glioma and primitive neuroectodermal tumor (MG-PNET) are rare, poorly characterized, pose diagnostic as well treatment dilemmas. We studied 53 MG-PNETs in patients from 12 to 80 years age (median = 54 years). The PNET-like component consisted sharply demarcated hypercellular nodules evidence neuronal differentiation. Anaplasia, seen medulloblastomas, was noted 70%. Within the element, N-myc or c-myc gene amplifications were...
In Brief We have reviewed clinically, morphologically, and immunophenotypically a series of 14 Epstein-Bar virus (EBV)+ cutaneous natural killer cell (NK)/T-cell lymphoma from Peru. Most (11 out 14) these cases fit well into the category Hydroa vacciniforme-like (HVLL), but 3 different clinical presentation, without facial involvement. all cases, skin lesions present in both sun-exposed nonexposed areas exhibited slowly progressive relapsing course, changing edema, to blistering, ulceration,...
More than 180 single nucleotide polymorphisms (SNPs) associated with breast cancer susceptibility have been identified; these SNPs can be combined into polygenic risk scores (PRS) to predict risk. Because most were identified in predominantly European populations, little is known about the performance of PRS non-Europeans. We tested a 180-SNP Latinas, large ethnic group variable levels Indigenous American, European, and African ancestry.We conducted pooled case-control analysis US Latinas...
Evaluation of features related to infiltrating immune cell level in glioblastoma.Tumor-infiltrating lymphocytes (TILs) through H&E staining, and TILs (CD3, CD4, CD8 CD20) macrophage (CD68 CD163) levels immunohistochemistry were evaluated digital analysis.CD68 (9.1%), CD163 (2.2%), CD3 (1.6%) had the highest density. Higher CD4+ was associated with unmethylated MGMT (p = 0.016). CD8+ larger tumoral size 0.027). CD163+ higher age 0.044) recursive partitioning analysis 4. Women < 0.05), total...
Women of Latin American origin in the United States are more likely to be diagnosed with advanced breast cancer and have a higher risk mortality than non-Hispanic White women. Studies U.S. Latinas women reported high incidence HER2 positive (+) tumors; however, factors contributing this observation unknown. Genome-wide genotype data for 1,312 patients from Peruvian Genetics Genomics Breast Cancer Study (PEGEN-BC) were used estimate genetic ancestry. We tested association between status...
BACKGROUND Astroblastoma is an extremely rare tumor of the central nervous system, and its origin validity as a different entity are still being debated. Because rarity similarities to other glial neoplasms, it often misdiagnosed, impacting treatment outcomes. OBSERVATIONS very mainly affects children young adults. It does not have definitive World Health Organization grade divided into low- high-grade categories. The clinical presentation consistent with signs intracranial hypertension....
<p>Supplemental Figure S2 shows performance of PRS panels with addition 2 or 3 H/L SNPs</p>
<p>Supplemental Figure S6 shows performance of PRS panels in H/L samples excluding discovery GWAS.</p>
<p>Supplemental Figure S3 shows performance of combinations European and Asian PRS panels in H/L samples.</p>
<p>Supplemental Figure S4 shows effect of adding only one H/L SNP to European PRS panels on performance in samples.</p>
<p>Supplemental Figure S1 shows global ancestry distribution of individuals by countries across seven studies included in this analysis.</p>
<p>Supplemental Table S2 shows performance of PRS panels constructed from PRS3820 European panel plus 2 H/L SNPs using different imputation r2 cutoffs.</p>
<p>Supplemental Table S3 shows sample sizes in the Indigenous American ancestry ranges selected for our analysis.</p>
<p>Supplemental Table S4 shows a list of polymorphisms in the PRS panels with association analyses summary statistics from 7 pooled Hispanic/Latino datasets.</p>
<p>Supplemental Figure S5 shows effect of adding only one H/L SNP to Asian PRS panels on performance in samples.</p>
<p>Supplemental Table S7 shows comparisons of performance for the PRS panel pairs in different ranges Indigenous American (IA) ancestry.</p>
<p>Supplemental Figure S7 shows performance of PRS panels in H/L samples with matched age cases and controls.</p>
<p>Supplemental Table S8 shows comparisons of performance the PRS panel for different pair ranges Indigenous American (IA) ancestry.</p>