Valentina A. Zavala
A5052538145- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Nutrition, Genetics, and Disease
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Genetic Associations and Epidemiology
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Animal Genetics and Reproduction
- Cancer-related Molecular Pathways
- Ocular Diseases and Behçet’s Syndrome
- Gene expression and cancer classification
- Forensic and Genetic Research
- Otitis Media and Relapsing Polychondritis
- Genetic Syndromes and Imprinting
- Pancreatic and Hepatic Oncology Research
- Genomic variations and chromosomal abnormalities
- Cancer Cells and Metastasis
- Colorectal Cancer Screening and Detection
- Genetics, Bioinformatics, and Biomedical Research
- Machine Learning in Bioinformatics
- Renal Diseases and Glomerulopathies
Regeneron (United States)
2023-2025
University of California, Davis
2021-2024
Pontificia Universidad Católica de Chile
2013-2023
University of California, San Francisco
2019-2020
Women of Latin American origin in the United States are more likely to be diagnosed with advanced breast cancer and have a higher risk mortality than non-Hispanic White women. Studies U.S. Latinas women reported high incidence HER2 positive (+) tumors; however, factors contributing this observation unknown. Genome-wide genotype data for 1,312 patients from Peruvian Genetics Genomics Breast Cancer Study (PEGEN-BC) were used estimate genetic ancestry. We tested association between status...
<p>Supplemental Figure S2 shows performance of PRS panels with addition 2 or 3 H/L SNPs</p>
<p>Supplemental Figure S6 shows performance of PRS panels in H/L samples excluding discovery GWAS.</p>
<p>Supplemental Figure S3 shows performance of combinations European and Asian PRS panels in H/L samples.</p>
<p>Supplemental Figure S4 shows effect of adding only one H/L SNP to European PRS panels on performance in samples.</p>
<p>Supplemental Figure S1 shows global ancestry distribution of individuals by countries across seven studies included in this analysis.</p>
<p>Supplemental Table S2 shows performance of PRS panels constructed from PRS3820 European panel plus 2 H/L SNPs using different imputation r2 cutoffs.</p>
<p>Supplemental Table S3 shows sample sizes in the Indigenous American ancestry ranges selected for our analysis.</p>
<p>Supplemental Table S4 shows a list of polymorphisms in the PRS panels with association analyses summary statistics from 7 pooled Hispanic/Latino datasets.</p>
<p>Supplemental Figure S5 shows effect of adding only one H/L SNP to Asian PRS panels on performance in samples.</p>
<p>Supplemental Table S7 shows comparisons of performance for the PRS panel pairs in different ranges Indigenous American (IA) ancestry.</p>
<p>Supplemental Figure S7 shows performance of PRS panels in H/L samples with matched age cases and controls.</p>
<p>Supplemental Table S8 shows comparisons of performance the PRS panel for different pair ranges Indigenous American (IA) ancestry.</p>
<p>Supplemental Table S5 shows Comparisons of Areas under the receiver operating characteristics curve (AUC) and odd ratios (OR) per standard deviation PRS panels.</p>
<p>Supplemental Table S6 shows two-sided Hosmer-Lemeshow P values for calibration of the PRS panels tested in our datasets.</p>
<div>AbstractBackground:<p>A substantial portion of the genetic predisposition for breast cancer is explained by multiple common variants relatively small effect. A subset these variants, which have been identified mostly in individuals European (EUR) and Asian ancestries, combined to construct a polygenic risk score (PRS) predict risk, but prediction accuracy existing PRSs Hispanic/Latinx (H/L) remain low. We assessed performance several PRS panels with without addition...
<p>Supplemental Table S1 shows description of the existing and modified PRS panels evaluated in our studies.</p>
<p>Supplemental Table S9 shows variants in European or Asian PRS panels with high linkage disequilibrium (LD) rs851980</p>
BACKGROUND: Mechanisms that lead to the reduced expression of BRCA1 in triple-negative breast cancer (TNBC) tumors are not fully understood. A possible cause is overexpression miR-146a and miR-638, which regulate other cancers. OBJECTIVE: To evaluate these m icroRNAs relation TNBC tumors. METHODS: Expression both microRNAs was assessed by real time qPCR using Taqman microRNA assays Results were related protein patient's survival. RESULTS: miR-638 overexpressed 36% 59% tumors, respectively....
Introduction Breast cancer is a heterogeneous disease, and the distribution of different subtypes varies by race/ethnic category in United States country. Established breast cancer-associated factors impact subtype-specific risk; however, these included limited or no representation Latin American diversity. To address this gap knowledge, we report description demographic, reproductive, lifestyle age at diagnosis disease subtype for The Peruvian Genetics Genomics Cancer (PEGEN-BC) study....
Abstract Background: Breast cancer incidence in the United States is lower Hispanic/Latina (H/L) compared with African American/Black or Non-Hispanic White women. An Indigenous American breast cancer–protective germline variant (rs140068132) has been reported near estrogen receptor 1 gene. This study tests association of rs140068132 and other polymorphisms 6q25 region subtype-specific risk H/Ls high ancestry. Methods: Genotypes were obtained for 5,094 Peruvian women (1,755) without (3,337)...