Magdalena Echeverry
A5015353610- Global Cancer Incidence and Screening
- Nutrition, Genetics, and Disease
- BRCA gene mutations in cancer
- Helicobacter pylori-related gastroenterology studies
- Genetic Associations and Epidemiology
- Forensic and Genetic Research
- Genetic factors in colorectal cancer
- Race, Genetics, and Society
- Galectins and Cancer Biology
- Eosinophilic Esophagitis
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Risks and Factors
- Veterinary medicine and infectious diseases
- Genetic and phenotypic traits in livestock
- Digestive system and related health
- Microbial Metabolites in Food Biotechnology
- Celiac Disease Research and Management
- Forensic Anthropology and Bioarchaeology Studies
University of Tolima
2018-2025
<p>Supplemental Figure S2 shows performance of PRS panels with addition 2 or 3 H/L SNPs</p>
<p>Supplemental Figure S6 shows performance of PRS panels in H/L samples excluding discovery GWAS.</p>
<p>Supplemental Figure S3 shows performance of combinations European and Asian PRS panels in H/L samples.</p>
<p>Supplemental Figure S4 shows effect of adding only one H/L SNP to European PRS panels on performance in samples.</p>
<p>Supplemental Figure S1 shows global ancestry distribution of individuals by countries across seven studies included in this analysis.</p>
<p>Supplemental Table S2 shows performance of PRS panels constructed from PRS3820 European panel plus 2 H/L SNPs using different imputation r2 cutoffs.</p>
<p>Supplemental Table S3 shows sample sizes in the Indigenous American ancestry ranges selected for our analysis.</p>
<p>Supplemental Table S4 shows a list of polymorphisms in the PRS panels with association analyses summary statistics from 7 pooled Hispanic/Latino datasets.</p>
<p>Supplemental Figure S5 shows effect of adding only one H/L SNP to Asian PRS panels on performance in samples.</p>
<p>Supplemental Table S7 shows comparisons of performance for the PRS panel pairs in different ranges Indigenous American (IA) ancestry.</p>
<p>Supplemental Figure S7 shows performance of PRS panels in H/L samples with matched age cases and controls.</p>
<p>Supplemental Table S8 shows comparisons of performance the PRS panel for different pair ranges Indigenous American (IA) ancestry.</p>
<p>Supplemental Table S5 shows Comparisons of Areas under the receiver operating characteristics curve (AUC) and odd ratios (OR) per standard deviation PRS panels.</p>
<p>Supplemental Table S6 shows two-sided Hosmer-Lemeshow P values for calibration of the PRS panels tested in our datasets.</p>
<div>AbstractBackground:<p>A substantial portion of the genetic predisposition for breast cancer is explained by multiple common variants relatively small effect. A subset these variants, which have been identified mostly in individuals European (EUR) and Asian ancestries, combined to construct a polygenic risk score (PRS) predict risk, but prediction accuracy existing PRSs Hispanic/Latinx (H/L) remain low. We assessed performance several PRS panels with without addition...
<p>Supplemental Table S1 shows description of the existing and modified PRS panels evaluated in our studies.</p>
<p>Supplemental Table S9 shows variants in European or Asian PRS panels with high linkage disequilibrium (LD) rs851980</p>
Helicobacter pylori have coevolved with mankind since its origins, adapting to different human groups. In America, H. has evolved into several subpopulations. We analysed the genome of 154 Colombian strains along 1,091 from worldwide populations discern ancestry and adaption people. Population structure was inferred FineStructure ChromoPainter. Phylogenetic relationship relative effect recombination were analysing core SNPs. Also, a Fst index calculated identify gene variants strongest...
Helicobacter pylori infection has been associated with various gastrointestinal disorders, including chronic gastritis, peptic ulcers, dyspepsia, and gastric cancer. This study aimed to compare the effectiveness of four invasive diagnostic methods for detecting H. in 297 patients premalignant lesions In this cross-sectional study, evaluated included Giemsa stain, vitro culture, rapid urease test, polymerase chain reaction. Patients were recruited between 2016 2019 Ibagué, a case definition...
Abstract Background: A substantial portion of the genetic predisposition for breast cancer is explained by multiple common variants relatively small effect. subset these variants, which have been identified mostly in individuals European and Asian ancestry, combined to construct a polygenic risk score (PRS) predict risk, but prediction accuracy existing PRSs Hispanic/Latinx (H/L) remain low. We assessed performance several PRS panels with without addition H/L specific among self-reported...
Introducción. El cáncer colorrectal es una carga para la salud pública en Colombia y el mundo. Estudios de asociación genética han identificado regiones cromosómicas asociadas a esta enfermedad, mostrando riesgo variable entre poblaciones, debido historia demográfica ancestría genética. Objetivo. Estudiar que aportan 20 marcadores al Colombia, empleando 955 casos 972 controles del consorcio CHIBCHA, analizando conjuntamente efecto global local. Metodología. Las muestras se genotipificaron...
We present the complete genome sequences of three Helicobacter pylori strains isolated from patients who resided in Tolima Department, Colombia, diagnosed with chronic gastritis. The genomes an average length 1.6 Mbp and 1,546 genes correspond to different H. subpopulations.
Abstract Helicobacter pylori have coevolved with mankind since its origins, adapting to different human groups. In America H. has evolved in several subpopulations specific for regions or even countries. this study we analyzed the genome of 163 Colombian strains along 1,113 that represent worldwide populations better discern ancestry and adaption people. Population structure was inferred FineStructure chromosome painting identifying proportion ancestries isolates. Phylogenetic relationship...