A5006804217- RNA modifications and cancer
- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- Molecular Biology Techniques and Applications
- Global Cancer Incidence and Screening
- Cancer Genomics and Diagnostics
- Genetic Associations and Epidemiology
- Chronic Disease Management Strategies
- Vaccine Coverage and Hesitancy
- Cancer-related Molecular Pathways
- Genomics and Rare Diseases
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- COVID-19 Clinical Research Studies
- Evolution and Genetic Dynamics
- Bayesian Methods and Mixture Models
- Healthcare Systems and Public Health
- Genetic and phenotypic traits in livestock
- COVID-19 and Mental Health
- Genomics and Chromatin Dynamics
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
University of Colorado Anschutz Medical Campus
2021-2025
University of Colorado Denver
2022
University of California, Berkeley
2019-2020
University of California, San Francisco
2020
Berkeley College
2019
More than 180 single nucleotide polymorphisms (SNPs) associated with breast cancer susceptibility have been identified; these SNPs can be combined into polygenic risk scores (PRS) to predict risk. Because most were identified in predominantly European populations, little is known about the performance of PRS non-Europeans. We tested a 180-SNP Latinas, large ethnic group variable levels Indigenous American, European, and African ancestry.We conducted pooled case-control analysis US Latinas...
Women of Latin American origin in the United States are more likely to be diagnosed with advanced breast cancer and have a higher risk mortality than non-Hispanic White women. Studies U.S. Latinas women reported high incidence HER2 positive (+) tumors; however, factors contributing this observation unknown. Genome-wide genotype data for 1,312 patients from Peruvian Genetics Genomics Breast Cancer Study (PEGEN-BC) were used estimate genetic ancestry. We tested association between status...
Abstract Background Over 180 single nucleotide polymorphisms (SNPs) associated with breast cancer susceptibility have been identified; these SNPs can be combined into polygenic risk scores (PRS) to predict risk. Since most were identified in predominantly European populations, little is known about the performance of PRS non-Europeans. We tested a 180-SNP Latinas, large ethnic group variable levels Indigenous American, European, and African ancestry. Methods conducted pooled case-control...
Genetic summary data are broadly accessible and highly useful including for risk prediction, causal inference, fine mapping, incorporation of external controls. However, collapsing individual-level into groups masks intra- inter-sample heterogeneity, leading to confounding, reduced power, bias. Ultimately, unaccounted substructure limits usability, especially understudied or admixed populations. Here, we present Summix2, a comprehensive set methods software based on computationally efficient...
Characterizing the experience and impact of COVID-19 pandemic among various populations remains challenging due to limitations inherent in common data sources, such as electronic health records (EHRs) or cross-sectional surveys.This study aims describe testing behaviors, symptoms, impact, vaccination status, case ascertainment during using integrated sources.In summer 2020 2021, we surveyed participants enrolled Biobank at Colorado Center for Personalized Medicine (CCPM; N=180,599) about...
Abstract There are few Latin American cohorts with available biospecimens that include women of high Indigenous ancestry. The Peruvian population is characterized by a degree Native (NA) ancestry, this ancestral component varying between 56 to 100% on average, depending the region. We have collected 1199 samples from Instituto Nacional de Enfermedades Neoplasicas in Lima. This cohort patients represents unique opportunity study molecular characteristics breast cancer NA genetic and genomic...
There are few Latin American cohorts with available biospecimens that include women of high Indigenous ancestry. The Peruvian population is characterized by a degree Native (NA) ancestry, this ancestral component varying between 56 to 100% on average, depending the region. We have collected 1199 samples from Instituto Nacional de Enfermedades Neoplasicas in Lima. This cohort patients represents unique opportunity study molecular characteristics breast cancer NA genetic and genomic...
ABSTRACT Background Characterizing the experience and impact of COVID-19 pandemic among various populations remains challenging due to limitations inherent in common data sources such as electronic health record (EHR) or convenience sample surveys. Objective To describe testing behaviors, symptoms, impact, vaccination status case ascertainment during using integrated sources. Methods In summer 2020 2021, we surveyed participants enrolled Biobank at Colorado Center for Personalized Medicine...
Abstract Publicly available genetic summary data have high utility in research and the clinic including prioritizing putative causal variants, polygenic scoring, leveraging common controls. However, summarizing individual-level can mask population structure resulting confounding, reduced power, incorrect prioritization of variants. This limits publicly data, especially for understudied or admixed populations where additional resources are most needed. While several methods exist to estimate...
Over 6.37 million people have died from COVID-19 worldwide, but factors influencing COVID-19-related mortality remain understudied. We aimed to describe and identify risk for in the Colorado Center Personalized Medicine (CCPM) Biobank using integrated data sources, including Electronic Health Records (EHRs). calculated cause-specific case-fatality rates common pre-existing health conditions defined by diagnostic phecodes encounters EHRs. performed multivariable logistic regression analyses...
<div>Abstract<p>Women of Latin American origin in the United States are more likely to be diagnosed with advanced breast cancer and have a higher risk mortality than non-Hispanic White women. Studies U.S. Latinas women reported high incidence HER2 positive (+) tumors; however, factors contributing this observation unknown. Genome-wide genotype data for 1,312 patients from Peruvian Genetics Genomics Breast Cancer Study (PEGEN-BC) were used estimate genetic ancestry. We tested...
<div>Abstract<p>Women of Latin American origin in the United States are more likely to be diagnosed with advanced breast cancer and have a higher risk mortality than non-Hispanic White women. Studies U.S. Latinas women reported high incidence HER2 positive (+) tumors; however, factors contributing this observation unknown. Genome-wide genotype data for 1,312 patients from Peruvian Genetics Genomics Breast Cancer Study (PEGEN-BC) were used estimate genetic ancestry. We tested...
<p>Association between ER/PR/HER2 defined groups and Indigenous American genetic ancestry including stage region of residence as covariates</p>
<p>Association between ER/PR/HER2 defined groups and European genetic ancestry (for every 10% increase)</p>
<p>Association between ER/PR/HER2 defined groups and European genetic ancestry (for every 10% increase)</p>
<p>Association between ER/PR/HER2 defined groups and Indigenous American genetic ancestry including stage region of residence as covariates</p>
Abstract Background: We previously investigated genetic ancestry associations with breast cancer subtypes in Peruvian women. found that women human epidermal growth factor receptor 2 (HER2) over-expressing tumors had higher Indigenous American than other subtypes. a suggestive association between African and triple negative (TNBC). hypothesized these could be due to the presence of germline variants genome or predisposing HER2 over-expression TNBC respectively. conducted wide analyses...
Background: We previously investigated genetic ancestry associations with breast cancer subtypes in Peruvian women. found that women human epidermal growth factor receptor 2 (HER2) over-expressing tumors had higher Indigenous American than other subtypes. a suggestive association between African and triple negative (TNBC). hypothesized these could be due to the presence of germline variants genome or predisposing HER2 over-expression TNBC respectively. conducted wide analyses explore this...
Abstract Background: We have previously identified a genetic variant, rs140068132, which has strong protective effect on breast cancer risk. This variant is located near the estrogen receptor 1 gene (ESR1) chromosome 6q25, locus been repeatedly implicated in Women who carry two copies of (GG) 60-70% reduction risk developing compared to women with none. The G relatively high frequency Latin American (up 23% 1000 Genomes Project Peruvians); it only common people Indigenous ancestry and almost...
Abstract The incidence of breast cancer is lower in women Latin American origin the U.S. compared to European and African women. Among Latinas, rs140068132A&gt;G variant, which common with IAA, has been associated a risk cancer. frequency G allele 0% for non-Latinos while 12% Latinos, being highest Peruvian population (23%). This variant located on chromosome 6 near Estrogen Receptor 1 gene (ESR1) even though experimental evidence suggests that this might be functional, molecular...
Abstract The incidence of Human Epidermal Growth Factor Receptor 2 positive (HER2+) breast cancer is higher in Latinas, both the U.S. and Latin America. Preliminary analyses Peruvian Genetics Genomics Breast Cancer (PEGEN-BC) study data set showed a strong association between Indigenous American (IA) component ancestry HER2 status independently stage at diagnosis other factors. aim this was to identify genetic loci associated with HER2+ patients high IA ancestry. To achieve we used admixture...