Xiaosong Huang
A5027399949- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- Global Cancer Incidence and Screening
- Genetic Associations and Epidemiology
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Cytokine Signaling Pathways and Interactions
- Health Literacy and Information Accessibility
- Cancer Risks and Factors
- Cancer-related molecular mechanisms research
- Health Systems, Economic Evaluations, Quality of Life
- Glycosylation and Glycoproteins Research
- Forensic and Genetic Research
- RNA modifications and cancer
- interferon and immune responses
- Race, Genetics, and Society
University of California, Davis
2022-2024
<p>Supplemental Figure S2 shows performance of PRS panels with addition 2 or 3 H/L SNPs</p>
<p>Supplemental Figure S6 shows performance of PRS panels in H/L samples excluding discovery GWAS.</p>
<p>Supplemental Figure S3 shows performance of combinations European and Asian PRS panels in H/L samples.</p>
<p>Supplemental Figure S4 shows effect of adding only one H/L SNP to European PRS panels on performance in samples.</p>
<p>Supplemental Figure S1 shows global ancestry distribution of individuals by countries across seven studies included in this analysis.</p>
<p>Supplemental Table S2 shows performance of PRS panels constructed from PRS3820 European panel plus 2 H/L SNPs using different imputation r2 cutoffs.</p>
<p>Supplemental Table S3 shows sample sizes in the Indigenous American ancestry ranges selected for our analysis.</p>
<p>Supplemental Table S4 shows a list of polymorphisms in the PRS panels with association analyses summary statistics from 7 pooled Hispanic/Latino datasets.</p>
<p>Supplemental Figure S5 shows effect of adding only one H/L SNP to Asian PRS panels on performance in samples.</p>
<p>Supplemental Table S7 shows comparisons of performance for the PRS panel pairs in different ranges Indigenous American (IA) ancestry.</p>
<p>Supplemental Figure S7 shows performance of PRS panels in H/L samples with matched age cases and controls.</p>
<p>Supplemental Table S8 shows comparisons of performance the PRS panel for different pair ranges Indigenous American (IA) ancestry.</p>
<p>Supplemental Table S5 shows Comparisons of Areas under the receiver operating characteristics curve (AUC) and odd ratios (OR) per standard deviation PRS panels.</p>
<p>Supplemental Table S6 shows two-sided Hosmer-Lemeshow P values for calibration of the PRS panels tested in our datasets.</p>
<div>AbstractBackground:<p>A substantial portion of the genetic predisposition for breast cancer is explained by multiple common variants relatively small effect. A subset these variants, which have been identified mostly in individuals European (EUR) and Asian ancestries, combined to construct a polygenic risk score (PRS) predict risk, but prediction accuracy existing PRSs Hispanic/Latinx (H/L) remain low. We assessed performance several PRS panels with without addition...
<p>Supplemental Table S1 shows description of the existing and modified PRS panels evaluated in our studies.</p>
<p>Supplemental Table S9 shows variants in European or Asian PRS panels with high linkage disequilibrium (LD) rs851980</p>
Abstract Background: A substantial portion of the genetic predisposition for breast cancer is explained by multiple common variants relatively small effect. subset these variants, which have been identified mostly in individuals European and Asian ancestry, combined to construct a polygenic risk score (PRS) predict risk, but prediction accuracy existing PRSs Hispanic/Latinx (H/L) remain low. We assessed performance several PRS panels with without addition H/L specific among self-reported...
Breast cancer is the most common in women United States (U.S.) and leading cause of related death among U.S. Hispanics/Latinas (H/Ls). H/Ls have lower rates screening longer time to follow up after an abnormal mammogram. We developed a comprehensive community health educator (promotores)-led education risk identification program for Spanish-speaking California increase mammography screening, genetic testing, understanding impact family history on risk. Due COVID-19, we adapted virtual...
Abstract Breast cancer subtype distribution differs between populations with dissimilar genetic ancestry backgrounds. Several breast risk single nucleotide polymorphisms (SNPs) were discovered in individuals of European and Asian origin. Hispanic/Latina women remain underrepresented studies public databases. The 6q25 locus contains multiple risk-associated SNPs. Some SNPs within this region have been associated the expression genes (eQTLs), such as Estrogen Receptor 1 gene (ESR1). Two...
Abstract Background: Breast cancer is the most common among women in US and leading cause of death who self-identify as Hispanics/Latinas (H/L). Approximately 5-10% breast can be attributed to inherited genetic mutations high penetrance genes such BRCA1 BRCA2. Studies have shown that counseling help their families make informed decisions about testing, which turn lead life-saving preventative strategies. H/L are less likely undergo testing than Non-Hispanic White women. To address this...
Abstract Genetic studies in women of Hispanic/Latina origin identified a single nucleotide polymorphism (SNP) the 6q25 region, rs140068132, that correlates with Indigenous American (IA) ancestry and is protective against BC. The underrepresentation Latin populations public databases has hindered study mechanisms by which this SNP confers effect. We aimed to identify IA germline variants associated BC risk test their association tumor gene expression region. performed case-control...
Abstract Purpose: Breast cancer incidence and outcomes differ by US census racial/ethnic category. Since large-scale genetic studies of human disease are predominately focused on populations European ancestry, little is known about breast molecular biology in Hispanic/Latinos which can widen health disparities due to suboptimal translation discoveries into clinical practice or public policy. We aim describe relevant pathways subtype differentiation patients from Peru. Patients Methods:...
Abstract Around 10% of genetic predisposition for breast cancer is explained by mutations in high/moderate penetrance genes. The remaining proportion multiple common variants relatively small effect. A subset these has been identified mostly Europeans and Asians; combined into polygenic risk scores (PRS) to predict risk. Our aim identify a improve prediction Hispanics/Latinas (H/Ls).Breast patients were recruited at the Instituto Nacional de Enfermedades Neoplásicas Peru, be part Peruvian...