A5075053446- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Cutaneous lymphoproliferative disorders research
- CAR-T cell therapy research
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Lung Cancer Treatments and Mutations
- Multiple Myeloma Research and Treatments
- Ovarian cancer diagnosis and treatment
- Economic and Financial Impacts of Cancer
- Acute Myeloid Leukemia Research
- Cancer-related gene regulation
- Monoclonal and Polyclonal Antibodies Research
- Fungal Infections and Studies
- CNS Lymphoma Diagnosis and Treatment
- Minimally Invasive Surgical Techniques
- Lymphadenopathy Diagnosis and Analysis
- Intestinal and Peritoneal Adhesions
- Abdominal Surgery and Complications
- Glioma Diagnosis and Treatment
- HIV/AIDS oral health manifestations
- Protein Degradation and Inhibitors
The University of Texas MD Anderson Cancer Center
2019-2024
Instituto Nacional de Enfermedades Neoplásicas
2016-2024
EsSALUD
2015-2021
Stevens Institute of Technology
2014
Novo Nordisk (United Kingdom)
2002
Merck Serono (Italy)
2002
Social Insurance Saitama Chuo Hospital
2002
Adult T-cell leukemia-lymphoma (ATLL) is an aggressive Human Leukemia Virus Type 1 (HTLV-1)-driven malignancy. Although Western hemisphere (Afro-Caribbean and South American) patients face worse prognoses, our understanding of ATLL molecular drivers derives mostly from Japanese studies. We performed multi-omic analyses to elucidate the genomic landscape in cohorts. Recurrent deletion and/or damaging mutations involving FOXO3, ANKRD11, DGKZ, PTPN6 implicate these genes as potential tumor...
Abstract Acute myeloid leukemia (AML) is the most common acute in adults. While induction chemotherapy leads to remission patients, a significant number will experience relapse. Therefore, there need for novel therapies that can improve rates patients with relapsed and refractory AML. CD70 natural ligand CD27 (a member of TNF superfamily) appears be promising therapeutic target. Consequently, considerable interest developing chimeric antigen receptor (CAR) T-cell therapy products...
Extranodal natural killer/T-cell lymphoma (ENKTL) is an aggressive, rare of killer (NK) cell origin with poor clinical outcomes. Here we used phenotypic and molecular profiling, including epigenetic analyses, to investigate how ENKTL ontogeny relates normal NK-cell development. We demonstrate that neoplastic NK cells are stably, but reversibly, arrested at earlier stages maturation. Genes downregulated in the most immature tumors were associated polycomb silencing along genomic gain...
Abstract Background We report extended follow-up of TROG99.03, a randomised phase III trial in early-stage follicular lymphoma (ESFL) including new information on the role adjuvant rituximab and translational studies. Methods Patients with ESFL were to involved-field radiotherapy (IFRT) or IFRT plus 6-cycles cyclophosphamide/vincristine/prednisolone (IFRT+CVP). From 2006 was added IFRT+CVP (IFRT+R-CVP). Clinical multi-omic parameters evaluated. Findings validated two independent cohorts (99...
Objetivo: Evaluar la utilización de tres trócares 10 mm y un manipulador uterino adaptado, en realización histerectomía laparoscópica total (HTL). Diseño: Estudio descriptivo retrospectivo. Institución: Servicio Gíneco Obstetrícia, Hospital III EsSalud, Puno, Perú. Participantes: Pacientes con indicación HTL. Intervenciones: En el periodo 2004 a 2010, se realizó por vía 78 pacientes HTL, uso bipolar, monopolar Liga Sure. Principales medidas resultados: Evaluación técnica quirúrgica,...
In recent years, the rapid technological development and better knowledge of genetic molecular aspects in medicine have allowed a approach to understand, diagnose treat various oncological diseases. Regarding lung carcinoma, there has been remarkable evolution from first classifications, which were purely morphological, last one issued 2015. This classification includes histological, immunophenotypic, genetics, clinical radiological information, allows evaluation therapeutic management these...
7012 Background: Acute Lymphoblastic Leukemia (ALL) in Latino countries is characterized by high incidence and worst outcomes compare to other ethnicities. However, the actual epidemiological characterization of ALL South America remains unknown. The lack registries, uniform treatment prospective protocols have been pointed out for these disparities. Also, biological, social aspects this disease play an important role that has not well examined. We aimed evaluate survival patients with acute...
e19569 Background: Non-Hodgkin lymphoma (NHL) is the most frequent hematological malignancy. B-cell (BCL) and T-cell (TCL) NHL subtypes differs in high income low-and middle-income countries. In Peru, healthcare system divided mainly into public private institutions. We aimed to describe of seen according facilities. Methods: reviewed medical records at National Cancer Institute Oncosalud, both leading cancer centers respectively. All patients diagnosed with from 2015-2018 2016 WHO...