A5052310700- Polyomavirus and related diseases
- Bacteriophages and microbial interactions
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Chronic Lymphocytic Leukemia Research
- Plant Virus Research Studies
- Acute Myeloid Leukemia Research
- Cutaneous lymphoproliferative disorders research
- Immunotherapy and Immune Responses
- Chronic Myeloid Leukemia Treatments
- CAR-T cell therapy research
- T-cell and Retrovirus Studies
- Cancer Genomics and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer survivorship and care
- Lung Cancer Treatments and Mutations
- Melanoma and MAPK Pathways
- Blood disorders and treatments
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Fungal Infections and Studies
- Neutropenia and Cancer Infections
- Reproductive Biology and Fertility
- Sexual function and dysfunction studies
The University of Texas MD Anderson Cancer Center
2016-2025
Massachusetts General Hospital
2020
Cancer Research And Biostatistics
2018
GlaxoSmithKline (Italy)
2016
Illumina (United States)
2016
Moffitt Cancer Center
2016
GlaxoSmithKline (India)
2016
Bristol-Myers Squibb (Germany)
2016
The University of Texas Health Science Center at Houston
2016
Duke University
2016
Brentuximab vedotin, a monoclonal antibody (cAC10) conjugated to monomethyl auristatin E, targets CD30(+) receptors. This phase II open-label trial was conducted evaluate safety and efficacy in cutaneous T-cell lymphomas.Forty-eight patients with lymphoproliferative disorders or mycosis fungoides (MF) received an infusion of 1.8 mg/kg every 21 days.Forty-eight evaluable (22 women 26 men; median age, 59.5 years) had overall response rate 73% (95% CI, 60% 86%; 35 48 patients) complete 35% 22%...
Background Non-small cell lung cancer (NSCLC) patients bearing targetable oncogene alterations typically derive limited benefit from immune checkpoint blockade (ICB), which has been attributed to low tumor mutation burden (TMB) and/or PD-L1 levels. We investigated oncogene-specific differences in these markers and clinical outcome. Methods Three cohorts of NSCLC with (n=4189 total) were analyzed. Two advanced treated ICB monotherapy [MD Anderson (MDACC; n=172) Flatiron Health-Foundation...
Mutant TP53 is an adverse risk factor in acute myeloid leukemia (AML), but large-scale integrated genomic-proteomic analyses of alterations patients with AML remain limited. We analyzed mutational status, copy number (CN), and protein expression data (N = 528) provide a compilation mutation sites types across disease subgroups among treated untreated patients. Our analysis shows differential hotspots subsets uncovers novel pathogenic variants involving splice sites. In addition, we...
Abstract BACKGROUND The majority of prostate carcinoma survivors experience enduring sexual difficulties and associated distress in the years after definitive treatment. A counseling intervention aimed at improving levels satisfaction increasing successful utilization medical treatment for erectile dysfunction (ED) was developed pilot‐tested both survivor his partner. METHODS All male participants were 3‐month to 5‐year localized who had been treated with radical prostatectomy or radiation...
After treatment for prostate cancer, multidisciplinary sexual rehabilitation involving couples appears more promising than traditional urologic erectile dysfunction (ED). The authors of this report conducted a randomized trial comparing or internet-based counseling with waitlist (WL) control.Couples were adaptively to 3-month WL, 3-session face-to-face format (FF), an (WEB1). A second group (WEB2) was added examine the relation between web site use and outcomes. At baseline, post-WL,...
To investigate the association between blood levels of C-reactive protein (CRP) in patients with melanoma and overall survival (OS), melanoma-specific (MSS), disease-free survival.Two independent sets plasma samples from a total 1,144 (587 initial 557 confirmatory) were available for CRP determination. Kaplan-Meier method Cox regression used to evaluate relationship clinical outcome. Among 115 who underwent sequential draws, we evaluated change disease status using nonparametric...
To evaluate for an association between 25-hydroxyvitamin D levels (vitamin D) and outcome measures in patients with melanoma after evaluation is controlled systemic inflammatory response (SIR) on the basis of simultaneous C-reactive protein (CRP) measurement.Plasma samples from 1,042 prospectively observed were assayed vitamin CRP. The associations demographics CRP determined, followed by a determination stage date blood draw. level was considered sufficient if it 30 to 100 ng/mL....
The purpose of this study is to determine if inhibition mitochondrial oxidative phosphorylation (OxPhos) an effective strategy against MAPK pathway inhibitor (MAPKi)-resistant BRAF-mutant melanomas.Experimental Design: antimelanoma activity IACS-010759 (OPi), a novel OxPhos complex I inhibitor, was evaluated in vitro and vivo. Mechanistic studies predictors response were using molecularly metabolically stratified melanoma cell lines. 13C-labeling targeted metabolomics used evaluate the...
Persistence of IDH1 or IDH2 mutations in remission bone marrow specimens patients with acute myeloid leukemia has been observed, but the clinical impact these is not well known. In this study, we evaluated 80 known R132 R140/R172 and assessed their at time to determine potential persistent IDH1/2 mutations. Approximately 40% given standard treatment cohort had Patients an mutation increased risk relapse after 1 year follow-up compared without a detectable (59% versus 24%; P<0.01). However,...
Abstract Background In the evaluation of PD-L1 expression to select patients for anti-PD-1/PD-L1 treatment, uniform guidelines that account different immunohistochemistry assays, cell types and cutoff values across tumor are lacking. Data on how scoring methods compare in breast cancer scant. Methods Using FDA-approved 22C3 diagnostic assay, we retrospectively evaluated 496 primary invasive tumors were not exposed treatment compared three (TC: cells; IC: tumor-infiltrating immune TCIC: a...
We designed a peer counseling program to improve sexual function, increase knowledge about reproductive health, and decrease menopausal symptoms infertility-related distress for African American breast cancer survivors.Women were randomly assigned immediate or 3-month waitlist. Three counselors conducted 3-session intervention using detailed workbook. Questionnaires at baseline, after the waitlist period, posttreatment, follow-up assessed spirituality, menopause symptoms, emotional distress,...
Sentinel lymph node (SLN) sampling may provide staging information without exposing patients to risks of dissection. There is no consensus protocol for optimal pathologic handling these specimens. This study compares 2 ultrastaging protocols SLN in endometrial carcinoma (EC). All were serially sectioned perpendicular the long axis mm intervals and entirely submitted routine hematoxylin eosin (H&E) processing. negative by processing had (US) one following: method 1 (M1), 5 H&E levels...
ABSTRACT Introduction Targeted therapies and immune checkpoint inhibitors (ICIs) have revolutionized the management of metastatic non–small cell lung cancer (NSCLC) over past decade. Methods This single-center observational study was conducted to describe programmed death-ligand 1 (PD-L1) testing, choice therapy, outcomes for adult patients with stage IV NSCLC initiating first-line therapy from 2017 through 2020, follow-up June 2021. Patient characteristics assessments were described...
Article AbstractObjective: To examine the effectiveness of quetiapine versus conventional antipsychotics in improving cognitive and functional outcomes. Method: Forty stable outpatients with DSM-IV schizophrenia treated public outpatient clinics were randomly assigned to continue taking antipsychotic medications or switch for 6 months, beginning September 1998 ending July 2000. Neurocognitive measures obtained at study entry, 3 months by raters blinded treatment. Group differences examined...
Abstract Purpose: Merkel cell carcinoma (MCC) is an aggressive cutaneous malignancy whose pathogenesis and prognosis are related to the integrity of host immune system. Despite promising clinical responses immune-checkpoint blockade, response resistance remain unpredictable, underscoring a critical need delineate novel prognostic biomarkers and/or therapeutic targets for this disease. Experimental Design: Expression immune-regulatory markers (PD-L2, B7-H3, B7-H4, IDO-1, ICOS, TIM3, LAG3,...
Summary The differential immunophenotypic characteristics of early T precursor ( ETP ) acute lymphoblastic leukaemia/lymphoma ALL remain incompletely characterized. study group n = 142) included 106 (74·7%) men and 36 (25·3%) women with a median age 34·9 years (range, 2–79) at diagnosis. Patients were subtyped by flow cytometry immunophenotyping as follows: 33 (23·2%) ; 32 (22·5%) non‐ 60 (42·2%) thymic 17 (12·1%) mature . Excepting definitional markers, there was significant expression the...
Highlights•CKS1B gain(1q+)/CDKN2C deletion (1p–) has shorter progression-free survival (PFS) despite propensity score matching.•PFS of 3 copies 1q+ was longer than ≥4 and approached significance•1q+/1p– suggestive being an independent risk factor for survival.ABSTRACTThe gain/amplification CKS1B gene at chromosome region 1q21 (1q+) is one the most common genetic aberrations in multiple myeloma (MM). Amplification frequently associated with CDKN2C 1p32 (1p–), which also inferior outcomes.In...