A5091645567- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- CAR-T cell therapy research
- Eosinophilic Disorders and Syndromes
- COVID-19 and healthcare impacts
- Chronic Lymphocytic Leukemia Research
- Hemoglobinopathies and Related Disorders
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Otitis Media and Relapsing Polychondritis
- Acute Lymphoblastic Leukemia research
- Ocular Diseases and Behçet’s Syndrome
- Prenatal Screening and Diagnostics
- Cancer-related cognitive impairment studies
- Muscle Physiology and Disorders
- Reproductive tract infections research
- Infection Control and Ventilation
- Urticaria and Related Conditions
- COVID-19 Clinical Research Studies
- Gout, Hyperuricemia, Uric Acid
- Neutropenia and Cancer Infections
- Chemotherapy-induced organ toxicity mitigation
- Frailty in Older Adults
UPMC Hillman Cancer Center
2024
The University of Texas MD Anderson Cancer Center
2019-2023
Methodist Healthcare
2023
Methodist Le Bonheur Healthcare
2022
Methodist University Hospital
2022
Georgetown University
2018-2020
National Heart Lung and Blood Institute
2018-2020
Washington Hospital
2020
MedStar Georgetown University Hospital
2020
Aretaeio Hospital
2018
Highlights•CKS1B gain(1q+)/CDKN2C deletion (1p–) has shorter progression-free survival (PFS) despite propensity score matching.•PFS of 3 copies 1q+ was longer than ≥4 and approached significance•1q+/1p– suggestive being an independent risk factor for survival.ABSTRACTThe gain/amplification CKS1B gene at chromosome region 1q21 (1q+) is one the most common genetic aberrations in multiple myeloma (MM). Amplification frequently associated with CDKN2C 1p32 (1p–), which also inferior outcomes.In...
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy with poor prognosis and considered incurable conventional chemotherapy. Small observational studies reported allogeneic hematopoietic transplantation (allo-HCT) offers durable remissions in patients BPDCN. We report an analysis of BPDCN who received allo-HCT, using data to the Center for International Blood Marrow Transplant Research (CIBMTR). identified 164 from 78 centers underwent allo-HCT between 2007...
Relapse after allogeneic hematopoietic cell transplantation (HCT) leads to poor survival in patients with acute myeloid leukemia (AML). A second HCT (HCT2) may achieve durable remission. To determine the outcomes of who received an HCT2 for relapsed AML and evaluate predictors overall (OS) progression-free (PFS). We retrospectively reviewed medical records adult underwent at our institution during 2000 2019. Ninety-one were identified a median age 44 years (range 18-73) HCT2. Donor types...
Background Immune checkpoint inhibitors (ICIs) are being used after allogeneic hematopoietic stem cell transplantation (alloHCT) to reverse immune dysfunction. However, a major concern for the use of ICIs alloHCT is increased risk graft-versus-host disease (GVHD). We analyzed association between GVHD prophylaxis and frequency in patients who had received ICI therapy alloHCT. Methods A retrospective study was performed 21 with acute myeloid leukemia (n=16) or myelodysplastic syndromes (n=5)...
Abstract Secondary central nervous system large B-cell lymphoma (SCNSL) is rare, with a generally poor prognosis. There limited data about the role of autologous stem cell transplantation (ASCT) in these high-risk patients. We explored this study treatment outcomes and prognostic factors for patients SCNSL who underwent ASCT. included all consecutive ASCT at our institution. Primary endpoints were progression-free survival (PFS) overall (OS). One-hundred two identified. Median age transplant...
Ifosfamide, an alkylating agent used in cancer treatments, can cause neurotoxicity. The clinical presentation range from mild symptoms such as acute confusion to non-convulsive seizures, severe irreversible coma, and death. benefit of methylene blue use treating ifosfamide-induced metabolic encephalopathy is not well established. In this article, we present 2 cases responsive treatment.
Immune-related adverse events affecting virtually every organ system have been described in individuals receiving immune checkpoint inhibitors. The spectrum of hematologic effects is diverse and includes autoimmune cytopenias, hemolysis, or inhibition coagulation factors. interplay inflammation the cascade complex, inhibitors can induce coagulopathy by disrupting intricate link between these pathways.We report acquired two patients treated with programmed death-ligand 1 antibodies,...
The cell of origin (COO) classification into germinal center B (GCB) and non-GCB types has been shown to predict survival outcomes in newly diagnosed diffuse large lymphoma (DLBCL). In the relapsed/refractory (R/R) setting, there is building evidence that COO does not prognosis after high-dose chemotherapy autologous stem transplantation (auto-SCT). present analysis aimed compare based on R/R DLBCL patients who underwent auto-SCT. This retrospective study included adult with auto-SCT at MD...
<h3>Background</h3> Hyperuricemia is common and along with comorbidities, increasing in prevalence. Though often asymptomatic hence, under diagnosed, it may be associated subclinical urate deposition. Ultrasound (US) imaging can detect deposition individuals hyperuricemia (ASU). <h3>Objectives</h3> To evaluate the association of comorbidities via US ASU. <h3>Methods</h3> ASU was defined as serum (sUA) >6 mg/dl; sUA <6 mg/dl served controls. Demographic (age, gender, BMI), comorbidity...
<h3>Background</h3> Rheumatoid Arthritis (RA) is a chronic inflammatory autoimmune disorder characterised by systemic inflammation of joints, in particular the synovial membrane, cartilage and bone. Leptin (LEP) adiponectin (ADIP) belong to distinct group biological molecules, adipokines which are secreted white adipose tissue have central role energy storage metabolism. <h3>Objectives</h3> To compare fasting serum LEP ADIP RA healthy controls investigate whether levels change following...
<h3>Background</h3> CD19-directed Chimeric Antigen Receptor T-Cell (CAR-T) therapy has emerged as a promising and novel treatment for relapsed refractory (r/r) B-cell malignancies. Efforts are directed towards increasing persistence of CAR-T cells, which is known to lead durable responses. Repeat infusions have been explored in clinical trials.<sup>1-14</sup> Here, we report second patient with diffuse large lymphoma (DLBCL). <h3>Methods</h3> A 60-year old man diagnosed r/r DLBCL received...
<h3>Background</h3> Behcet9s disease (BD) is a rare systemic inflammatory disorder characterized by specific clinical features<sup>1</sup> that are well known to rheumatologists worldwide. It particularly common in the Mediterranean, Middle and Far East, but very rest of world.<sup>1</sup> Furthermore, there indications prevalence BD Cyprus high - for example ten times UK.<sup>2</sup> For this reason, it would be important physicians not only aware existence also able detect it. Early...
<h3>Objectives</h3> Assess safety and efficacy of GLM+MTX over 1yr in a multicenter, randomized, placebo (PBO)-controlled study Chinese pts with active RA despite MTX therapy. <h3>Methods</h3> 264 were randomized (1:1) to subcutaneous PBO+MTX (Group1) or GLM 50mg+MTX (Group2) q4wks. All received stable doses oral (7.5-20mg/wk). Group1 inadequate treatment response entered blinded early escape at wk16. remaining switched wk24. Blinding randomization assignment was maintained through wk 56....
<h3>Background</h3> Behcet's disease (BD) has a high incidence in countries of the middle through to far East and there are studies demographics characteristics from Turkey Greece, Japan<sup>1</sup>. No such information exists for Cyprus. One would expect incidence, but this never been studied. There regional differences be important know regarding Cyprus, given its geographical position an area prevalence BD. <h3>Objectives</h3> This is first attempt at describing patient (demographics,...